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Advances in pharmacological strategies for the prevention of cataract development.

Gupta SK, Selvan VK, Agrawal SS, Saxena R - Indian J Ophthalmol (2009 May-Jun)

Bottom Line: Cataractous-opacification of the lens is one of the leading causes of blindness in India.The situation can be managed by surgical removal of the cataractous lens.Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients.

View Article: PubMed Central - PubMed

Affiliation: Delhi Institute of Pharmaceutical Sciences and Research, Sector 3, Pushp Vihar, New Delhi-110 017, India. skgup@hotmail.com

ABSTRACT
Cataractous-opacification of the lens is one of the leading causes of blindness in India. The situation can be managed by surgical removal of the cataractous lens. Various pharmacological strategies have been proposed for the prevention and treatment of cataract. Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients. This review deals with the various mechanisms, and possible pharmacological interventions for the prevention of cataract. The article also reviews research on potential anticataractous agents, including aldose reductase inhibitors, glutathione boosters, antiglycating agents, vitamins and various drugs from indigenous sources.

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Related in: MedlinePlus

Synthesis of glutathione within the lens
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Figure 0005: Synthesis of glutathione within the lens

Mentions: The most important function of glutathione (GSH) is to deactivate and render excess free radicals and keep them harmless. GSH is composed of the amino acids cysteine, glutamic acid, and glycine, and its synthesis within the lens takes place in two ATP-dependent steps [Fig. 5]. There are several ways in which GSH or its depletion can affect the opacity of the lens. A review by researchers on GSH[56] the mechanisms of cataract prevention is: (1) maintaining sulfhydryl (SH) groups on proteins in their reduced form preventing disulfide cross-linkage; (2) protecting SH groups on proteins important for active transport and membrane permeability; and (3) preventing oxidative damage from H2 O2.


Advances in pharmacological strategies for the prevention of cataract development.

Gupta SK, Selvan VK, Agrawal SS, Saxena R - Indian J Ophthalmol (2009 May-Jun)

Synthesis of glutathione within the lens
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2683438&req=5

Figure 0005: Synthesis of glutathione within the lens
Mentions: The most important function of glutathione (GSH) is to deactivate and render excess free radicals and keep them harmless. GSH is composed of the amino acids cysteine, glutamic acid, and glycine, and its synthesis within the lens takes place in two ATP-dependent steps [Fig. 5]. There are several ways in which GSH or its depletion can affect the opacity of the lens. A review by researchers on GSH[56] the mechanisms of cataract prevention is: (1) maintaining sulfhydryl (SH) groups on proteins in their reduced form preventing disulfide cross-linkage; (2) protecting SH groups on proteins important for active transport and membrane permeability; and (3) preventing oxidative damage from H2 O2.

Bottom Line: Cataractous-opacification of the lens is one of the leading causes of blindness in India.The situation can be managed by surgical removal of the cataractous lens.Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients.

View Article: PubMed Central - PubMed

Affiliation: Delhi Institute of Pharmaceutical Sciences and Research, Sector 3, Pushp Vihar, New Delhi-110 017, India. skgup@hotmail.com

ABSTRACT
Cataractous-opacification of the lens is one of the leading causes of blindness in India. The situation can be managed by surgical removal of the cataractous lens. Various pharmacological strategies have been proposed for the prevention and treatment of cataract. Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients. This review deals with the various mechanisms, and possible pharmacological interventions for the prevention of cataract. The article also reviews research on potential anticataractous agents, including aldose reductase inhibitors, glutathione boosters, antiglycating agents, vitamins and various drugs from indigenous sources.

Show MeSH
Related in: MedlinePlus