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Advances in pharmacological strategies for the prevention of cataract development.

Gupta SK, Selvan VK, Agrawal SS, Saxena R - Indian J Ophthalmol (2009 May-Jun)

Bottom Line: Cataractous-opacification of the lens is one of the leading causes of blindness in India.The situation can be managed by surgical removal of the cataractous lens.Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients.

View Article: PubMed Central - PubMed

Affiliation: Delhi Institute of Pharmaceutical Sciences and Research, Sector 3, Pushp Vihar, New Delhi-110 017, India. skgup@hotmail.com

ABSTRACT
Cataractous-opacification of the lens is one of the leading causes of blindness in India. The situation can be managed by surgical removal of the cataractous lens. Various pharmacological strategies have been proposed for the prevention and treatment of cataract. Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients. This review deals with the various mechanisms, and possible pharmacological interventions for the prevention of cataract. The article also reviews research on potential anticataractous agents, including aldose reductase inhibitors, glutathione boosters, antiglycating agents, vitamins and various drugs from indigenous sources.

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Major risk factors implicated in cataractogenesis
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Figure 0001: Major risk factors implicated in cataractogenesis

Mentions: Apart from the above mentioned risk factors, genetic factors, socioeconomic status, illiteracy, malnutrition, diarrhea, myopia, renal failure, hypertension, sunlight, ultraviolet (UV) exposure, obesity, chemical burn, glaucoma and alcohol[1617] have also been implicated in cataractogenesis [Fig. 1].


Advances in pharmacological strategies for the prevention of cataract development.

Gupta SK, Selvan VK, Agrawal SS, Saxena R - Indian J Ophthalmol (2009 May-Jun)

Major risk factors implicated in cataractogenesis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2683438&req=5

Figure 0001: Major risk factors implicated in cataractogenesis
Mentions: Apart from the above mentioned risk factors, genetic factors, socioeconomic status, illiteracy, malnutrition, diarrhea, myopia, renal failure, hypertension, sunlight, ultraviolet (UV) exposure, obesity, chemical burn, glaucoma and alcohol[1617] have also been implicated in cataractogenesis [Fig. 1].

Bottom Line: Cataractous-opacification of the lens is one of the leading causes of blindness in India.The situation can be managed by surgical removal of the cataractous lens.Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients.

View Article: PubMed Central - PubMed

Affiliation: Delhi Institute of Pharmaceutical Sciences and Research, Sector 3, Pushp Vihar, New Delhi-110 017, India. skgup@hotmail.com

ABSTRACT
Cataractous-opacification of the lens is one of the leading causes of blindness in India. The situation can be managed by surgical removal of the cataractous lens. Various pharmacological strategies have been proposed for the prevention and treatment of cataract. Information on possible benefits of putative anticataract agents comes from a variety of approaches, ranging from laboratory experiments, both in vitro and in vivo , to epidemiological studies in patients. This review deals with the various mechanisms, and possible pharmacological interventions for the prevention of cataract. The article also reviews research on potential anticataractous agents, including aldose reductase inhibitors, glutathione boosters, antiglycating agents, vitamins and various drugs from indigenous sources.

Show MeSH
Related in: MedlinePlus