A method for improving the performance of gradient systems for diffusion-weighted MRI.
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This effect can be increased by the use of large, balanced bipolar gradients.It was found that the gradient axes (+/-x, +/-y, +/-z) were calibrated differently, resulting in offset ADC values.In addition, fiber tracking results in the human brain were noticeably affected by improving the gradient system calibration.
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PubMed Central - PubMed
Affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK. z.nagy@fil.ion.ucl.ac.uk
ABSTRACT
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The MR signal is sensitive to diffusion. This effect can be increased by the use of large, balanced bipolar gradients. The gradient systems of MR scanners are calibrated at installation and during regular servicing visits. Because the measured apparent diffusion constant (ADC) depends on the square of the amplitude of the diffusion sensitizing gradients, errors in the gradient calibration are exaggerated. If the error is varying among the different gradient axes, it will affect the estimated degree of anisotropy. To assess the gradient calibration accuracy in a whole-body MRI scanner, ADC values were calculated for a uniform water phantom along each gradient direction while monitoring the temperature. Knowledge of the temperature allows the expected diffusion constant of water to be calculated independent of the MRI measurement. It was found that the gradient axes (+/-x, +/-y, +/-z) were calibrated differently, resulting in offset ADC values. A method is presented to rescale the amplitude of each of the six principal gradient axes within the MR pulse sequence. The scaling factor is the square root of the ratio of the expected and observed diffusion constants. In addition, fiber tracking results in the human brain were noticeably affected by improving the gradient system calibration. |
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Mentions: For experiment 1, ADC values along 60 different directions are shown in Fig. 1a. Contrary to the expectation of spatially uniform ADC values, there is a high degree of variability in this measurement. The percent difference between the minimum and maximum ADC values from this measurement is 6.9%. In contrast the mean coefficient of variation of the 60 regions of interest was 4.3%, leading to a standard error of the mean of about 0.4%.Figure 1 |
View Article: PubMed Central - PubMed
Affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK. z.nagy@fil.ion.ucl.ac.uk