Limits...
Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management.

Lau FC, Bagchi M, Sen C, Roy S, Bagchi D - Curr. Genomics (2008)

Bottom Line: Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic.Among these supplements, (-)-hydroxycitric acid (HCA), a natural extract isolated from the dried fruit rind of Garcinia cambogia, and the micronutrient niacin-bound chromium(III) (NBC) have been shown to be safe and efficacious for weight loss.The potential biological mechanisms underlying the observed beneficial effects of these supplements as elucidated by the state-of-the-art nutrigenomic technologies will be systematically discussed in this review.

View Article: PubMed Central - PubMed

Affiliation: InterHealth Research Center, Benicia, CA, USA.

ABSTRACT
Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nutrigenomics, a new discipline in the field of nutritional research. Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic. According to the World Health Organization, more than 60% of the global disease burden will be attributed to chronic disorders associated with obesity by 2020. Meanwhile in the US, the prevalence of obesity has doubled in adults and tripled in children during the past three decades. In this regard, a number of natural dietary supplements and micronutrients have been studied for their potential in weight management. Among these supplements, (-)-hydroxycitric acid (HCA), a natural extract isolated from the dried fruit rind of Garcinia cambogia, and the micronutrient niacin-bound chromium(III) (NBC) have been shown to be safe and efficacious for weight loss. Utilizing cDNA microarrays, we demonstrated for the first time that HCA-supplementation altered the expression of genes involved in lipolytic and adipogenic pathways in adipocytes from obese women and up-regulated the expression of serotonin receptor gene in the abdominal fat of rats. Similarly, we showed that NBC-supplementation up-regulated the expression of myogenic genes while suppressed the expression of genes that are highly expressed in brown adipose tissue in diabetic obese mice. The potential biological mechanisms underlying the observed beneficial effects of these supplements as elucidated by the state-of-the-art nutrigenomic technologies will be systematically discussed in this review.

No MeSH data available.


Related in: MedlinePlus

Distinctions between nutrigenomics and nutrigenetics. The investigation of how food components modulate changes in gene expression profile or transcriptome is defined as nutrigenomics. One the other hand, nutrigenetics is defined as the study of how genetic variations such as single nucleotide polymorphism (SNP) among individuals affect their response to specific food components.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2682937&req=5

Figure 1: Distinctions between nutrigenomics and nutrigenetics. The investigation of how food components modulate changes in gene expression profile or transcriptome is defined as nutrigenomics. One the other hand, nutrigenetics is defined as the study of how genetic variations such as single nucleotide polymorphism (SNP) among individuals affect their response to specific food components.

Mentions: The term nutrigenetics is sometimes used interchangeably with nutrigenomics. However, nutrigenetics is the retrospective investigation of how genetic variations such as single nucleotide polymorphisms (SNPs) in haplotype maps (HapMap) give rise to differences in response to specific nutrients and eventually lead to differences in health and disease status among individuals [23, 24]. Fig. (1) illustrates the distinctions between nutrigenomics and nutrigenetics in simple terms. This chapter will focus on the application of nutrigenomics to weight management.


Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management.

Lau FC, Bagchi M, Sen C, Roy S, Bagchi D - Curr. Genomics (2008)

Distinctions between nutrigenomics and nutrigenetics. The investigation of how food components modulate changes in gene expression profile or transcriptome is defined as nutrigenomics. One the other hand, nutrigenetics is defined as the study of how genetic variations such as single nucleotide polymorphism (SNP) among individuals affect their response to specific food components.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2682937&req=5

Figure 1: Distinctions between nutrigenomics and nutrigenetics. The investigation of how food components modulate changes in gene expression profile or transcriptome is defined as nutrigenomics. One the other hand, nutrigenetics is defined as the study of how genetic variations such as single nucleotide polymorphism (SNP) among individuals affect their response to specific food components.
Mentions: The term nutrigenetics is sometimes used interchangeably with nutrigenomics. However, nutrigenetics is the retrospective investigation of how genetic variations such as single nucleotide polymorphisms (SNPs) in haplotype maps (HapMap) give rise to differences in response to specific nutrients and eventually lead to differences in health and disease status among individuals [23, 24]. Fig. (1) illustrates the distinctions between nutrigenomics and nutrigenetics in simple terms. This chapter will focus on the application of nutrigenomics to weight management.

Bottom Line: Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic.Among these supplements, (-)-hydroxycitric acid (HCA), a natural extract isolated from the dried fruit rind of Garcinia cambogia, and the micronutrient niacin-bound chromium(III) (NBC) have been shown to be safe and efficacious for weight loss.The potential biological mechanisms underlying the observed beneficial effects of these supplements as elucidated by the state-of-the-art nutrigenomic technologies will be systematically discussed in this review.

View Article: PubMed Central - PubMed

Affiliation: InterHealth Research Center, Benicia, CA, USA.

ABSTRACT
Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nutrigenomics, a new discipline in the field of nutritional research. Nutrigenomics may provide the strategies for the development of safe and effective dietary interventions against the obesity epidemic. According to the World Health Organization, more than 60% of the global disease burden will be attributed to chronic disorders associated with obesity by 2020. Meanwhile in the US, the prevalence of obesity has doubled in adults and tripled in children during the past three decades. In this regard, a number of natural dietary supplements and micronutrients have been studied for their potential in weight management. Among these supplements, (-)-hydroxycitric acid (HCA), a natural extract isolated from the dried fruit rind of Garcinia cambogia, and the micronutrient niacin-bound chromium(III) (NBC) have been shown to be safe and efficacious for weight loss. Utilizing cDNA microarrays, we demonstrated for the first time that HCA-supplementation altered the expression of genes involved in lipolytic and adipogenic pathways in adipocytes from obese women and up-regulated the expression of serotonin receptor gene in the abdominal fat of rats. Similarly, we showed that NBC-supplementation up-regulated the expression of myogenic genes while suppressed the expression of genes that are highly expressed in brown adipose tissue in diabetic obese mice. The potential biological mechanisms underlying the observed beneficial effects of these supplements as elucidated by the state-of-the-art nutrigenomic technologies will be systematically discussed in this review.

No MeSH data available.


Related in: MedlinePlus