Modeling kinetics of subcellular disposition of chemicals.
Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, North Dakota 58105, USA. firstname.lastname@example.orgShow MeSH
Mentions: The DAcPC molecules do not measurably partition from the concentrated aqueous solution (1.96 mol/L) into n-hexadecane (C16) in the two-phase system. For a set of 16 compounds, the C16/DAcPC partition coefficients were measured and used to estimate the prevalent location of the compounds in the bilayer. The difference logPC16/W − logPO/W (formally equal to logPC16/O) is frequently considered to be an indicator of the hydrogen-bonding ability,549,550,554,555 a correlate for permeability,(556) and a parameter characterizing the preferential location of solutes in the bilayer. The fraction of compounds present in the core, as estimated from the C16/DAcPC partition coefficients, is plotted against log PC16/O in Figure 6. To connect the compounds with known locale in the headgroups or in the core, the data were fitted(557) with the Boltzmann sigmoidal function:(552)
Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, North Dakota 58105, USA. email@example.com