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Modeling kinetics of subcellular disposition of chemicals.

Balaz S - Chem. Rev. (2009)

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, North Dakota 58105, USA. stefan.balaz@ndsu.edu

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Structure-based subcellular pharmacokinetics and related sciences. Two-sided arrows indicate mutual influence; one-sided arrows indicate supportive roles.
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Related In: Results  -  Collection

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fig1: Structure-based subcellular pharmacokinetics and related sciences. Two-sided arrows indicate mutual influence; one-sided arrows indicate supportive roles.

Mentions: SBSP relies on other disciplines for methodological support: principles of dynamic modeling(53) are used to simplify the models; computational chemistry provides simulation techniques and molecular characteristics; chemical kinetics supplies some modeling schemes and approximations; physical organic chemistry lends LFER; biophysical methods are used to study transport; and biochemical approaches deliver the binding data for the interactions of chemicals with body constituents. The interplay between SBSP and other disciplines is outlined in Figure 1. A special effort has been made to compare and integrate, where feasible, the approaches to the analysis of the same phenomenon in different areas.


Modeling kinetics of subcellular disposition of chemicals.

Balaz S - Chem. Rev. (2009)

Structure-based subcellular pharmacokinetics and related sciences. Two-sided arrows indicate mutual influence; one-sided arrows indicate supportive roles.
© Copyright Policy - open-access - ccc-price
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2682929&req=5

fig1: Structure-based subcellular pharmacokinetics and related sciences. Two-sided arrows indicate mutual influence; one-sided arrows indicate supportive roles.
Mentions: SBSP relies on other disciplines for methodological support: principles of dynamic modeling(53) are used to simplify the models; computational chemistry provides simulation techniques and molecular characteristics; chemical kinetics supplies some modeling schemes and approximations; physical organic chemistry lends LFER; biophysical methods are used to study transport; and biochemical approaches deliver the binding data for the interactions of chemicals with body constituents. The interplay between SBSP and other disciplines is outlined in Figure 1. A special effort has been made to compare and integrate, where feasible, the approaches to the analysis of the same phenomenon in different areas.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, North Dakota 58105, USA. stefan.balaz@ndsu.edu

Show MeSH