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Noninvasive cardiac flow assessment using high speed magnetic resonance fluid motion tracking.

Wong KK, Kelso RM, Worthley SG, Sanders P, Mazumdar J, Abbott D - PLoS ONE (2009)

Bottom Line: Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart.We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information.Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biomedical Engineering and School of Electrical & Electronic Engineering, University of Adelaide, Adelaide, South Australia. kelvin.wong@adelaide.edu.au

ABSTRACT
Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart. We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information. Using steady-state free precession magnetic resonance images of blood, we demonstrate intensity contrast between asynchronous and synchronous proton spins. Turbulent blood flow in cardiac chambers contains asynchronous blood proton spins whose concentration affects the signal intensities that are registered onto the magnetic resonance images. Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion. We verify this theory in a patient with an atrial septal defect whose chamber blood flow vortices vary in speed of rotation before and after septal occlusion. Based on the measurement of cardiac flow vorticity in our implementation, we establish a relationship between atrial vorticity and septal defect. The developed system has the potential to be used as a prognostic and investigative tool for assessment of cardiac abnormalities, and can be exploited in parallel to examining myocardial defects using steady-state free precession magnetic resonance images of the heart.

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Cardiac vorticity visualization system for ASD investigation.This system is specially constructed to review vorticity characteristics in patients with atrial septal defect (ASD) and relies on computational post-processing of MR images. The vorticity visualization system flow shows data processed by blocks depicting the MR imaging which provides data for generation of flow field flows. Flow visualization is achieved by field display using vector plot with the superposition of MR intensity images. Statistical analysis is supported by histograms of the vorticity maps.
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pone-0005688-g010: Cardiac vorticity visualization system for ASD investigation.This system is specially constructed to review vorticity characteristics in patients with atrial septal defect (ASD) and relies on computational post-processing of MR images. The vorticity visualization system flow shows data processed by blocks depicting the MR imaging which provides data for generation of flow field flows. Flow visualization is achieved by field display using vector plot with the superposition of MR intensity images. Statistical analysis is supported by histograms of the vorticity maps.

Mentions: We implement a vorticity visualization system dedicated to the examination of flow behavior in the heart chambers. We examine the system flow stages from imaging of patient with atrial septal defect to the visualization of cardiac flow field and statistical analysis of the vortical flow in atrium of the imaged heart (Fig. 10). Flow visualization is performed at the post-processing stage whereby vector plot is computed based on image intensity motion vectors for every pixel. The segmentation is required for isolating the region within the chamber for observation (Movie S3) and also for selecting only the relevant vorticity values in the atrium to be used statistically for analysis.


Noninvasive cardiac flow assessment using high speed magnetic resonance fluid motion tracking.

Wong KK, Kelso RM, Worthley SG, Sanders P, Mazumdar J, Abbott D - PLoS ONE (2009)

Cardiac vorticity visualization system for ASD investigation.This system is specially constructed to review vorticity characteristics in patients with atrial septal defect (ASD) and relies on computational post-processing of MR images. The vorticity visualization system flow shows data processed by blocks depicting the MR imaging which provides data for generation of flow field flows. Flow visualization is achieved by field display using vector plot with the superposition of MR intensity images. Statistical analysis is supported by histograms of the vorticity maps.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2682657&req=5

pone-0005688-g010: Cardiac vorticity visualization system for ASD investigation.This system is specially constructed to review vorticity characteristics in patients with atrial septal defect (ASD) and relies on computational post-processing of MR images. The vorticity visualization system flow shows data processed by blocks depicting the MR imaging which provides data for generation of flow field flows. Flow visualization is achieved by field display using vector plot with the superposition of MR intensity images. Statistical analysis is supported by histograms of the vorticity maps.
Mentions: We implement a vorticity visualization system dedicated to the examination of flow behavior in the heart chambers. We examine the system flow stages from imaging of patient with atrial septal defect to the visualization of cardiac flow field and statistical analysis of the vortical flow in atrium of the imaged heart (Fig. 10). Flow visualization is performed at the post-processing stage whereby vector plot is computed based on image intensity motion vectors for every pixel. The segmentation is required for isolating the region within the chamber for observation (Movie S3) and also for selecting only the relevant vorticity values in the atrium to be used statistically for analysis.

Bottom Line: Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart.We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information.Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biomedical Engineering and School of Electrical & Electronic Engineering, University of Adelaide, Adelaide, South Australia. kelvin.wong@adelaide.edu.au

ABSTRACT
Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart. We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information. Using steady-state free precession magnetic resonance images of blood, we demonstrate intensity contrast between asynchronous and synchronous proton spins. Turbulent blood flow in cardiac chambers contains asynchronous blood proton spins whose concentration affects the signal intensities that are registered onto the magnetic resonance images. Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion. We verify this theory in a patient with an atrial septal defect whose chamber blood flow vortices vary in speed of rotation before and after septal occlusion. Based on the measurement of cardiac flow vorticity in our implementation, we establish a relationship between atrial vorticity and septal defect. The developed system has the potential to be used as a prognostic and investigative tool for assessment of cardiac abnormalities, and can be exploited in parallel to examining myocardial defects using steady-state free precession magnetic resonance images of the heart.

Show MeSH
Related in: MedlinePlus