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Noninvasive cardiac flow assessment using high speed magnetic resonance fluid motion tracking.

Wong KK, Kelso RM, Worthley SG, Sanders P, Mazumdar J, Abbott D - PLoS ONE (2009)

Bottom Line: Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart.We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information.Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biomedical Engineering and School of Electrical & Electronic Engineering, University of Adelaide, Adelaide, South Australia. kelvin.wong@adelaide.edu.au

ABSTRACT
Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart. We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information. Using steady-state free precession magnetic resonance images of blood, we demonstrate intensity contrast between asynchronous and synchronous proton spins. Turbulent blood flow in cardiac chambers contains asynchronous blood proton spins whose concentration affects the signal intensities that are registered onto the magnetic resonance images. Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion. We verify this theory in a patient with an atrial septal defect whose chamber blood flow vortices vary in speed of rotation before and after septal occlusion. Based on the measurement of cardiac flow vorticity in our implementation, we establish a relationship between atrial vorticity and septal defect. The developed system has the potential to be used as a prognostic and investigative tool for assessment of cardiac abnormalities, and can be exploited in parallel to examining myocardial defects using steady-state free precession magnetic resonance images of the heart.

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Related in: MedlinePlus

Summary of ASD investigation.The histograms depicting the vorticity comparison for pre- versus post-atrial septal occlusion show that there is a distinct difference between the temporal average of the vorticity means based on a set of selected time frames. Twenty-six patients are used in the framework presented in this study. This investigation may be able to show that the application of vorticity statistics is useful in characterizing abnormal flows in a heart chamber with septal defect.
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pone-0005688-g007: Summary of ASD investigation.The histograms depicting the vorticity comparison for pre- versus post-atrial septal occlusion show that there is a distinct difference between the temporal average of the vorticity means based on a set of selected time frames. Twenty-six patients are used in the framework presented in this study. This investigation may be able to show that the application of vorticity statistics is useful in characterizing abnormal flows in a heart chamber with septal defect.

Mentions: We carried out the same experiments on the twenty-six patients. Temporal averaging of the ensemble vorticity means based on four or more selected time frames (when the vortices are the strongest) is performed. The results are summarized in Figure 7.


Noninvasive cardiac flow assessment using high speed magnetic resonance fluid motion tracking.

Wong KK, Kelso RM, Worthley SG, Sanders P, Mazumdar J, Abbott D - PLoS ONE (2009)

Summary of ASD investigation.The histograms depicting the vorticity comparison for pre- versus post-atrial septal occlusion show that there is a distinct difference between the temporal average of the vorticity means based on a set of selected time frames. Twenty-six patients are used in the framework presented in this study. This investigation may be able to show that the application of vorticity statistics is useful in characterizing abnormal flows in a heart chamber with septal defect.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2682657&req=5

pone-0005688-g007: Summary of ASD investigation.The histograms depicting the vorticity comparison for pre- versus post-atrial septal occlusion show that there is a distinct difference between the temporal average of the vorticity means based on a set of selected time frames. Twenty-six patients are used in the framework presented in this study. This investigation may be able to show that the application of vorticity statistics is useful in characterizing abnormal flows in a heart chamber with septal defect.
Mentions: We carried out the same experiments on the twenty-six patients. Temporal averaging of the ensemble vorticity means based on four or more selected time frames (when the vortices are the strongest) is performed. The results are summarized in Figure 7.

Bottom Line: Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart.We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information.Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion.

View Article: PubMed Central - PubMed

Affiliation: Centre for Biomedical Engineering and School of Electrical & Electronic Engineering, University of Adelaide, Adelaide, South Australia. kelvin.wong@adelaide.edu.au

ABSTRACT
Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart. We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information. Using steady-state free precession magnetic resonance images of blood, we demonstrate intensity contrast between asynchronous and synchronous proton spins. Turbulent blood flow in cardiac chambers contains asynchronous blood proton spins whose concentration affects the signal intensities that are registered onto the magnetic resonance images. Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion. We verify this theory in a patient with an atrial septal defect whose chamber blood flow vortices vary in speed of rotation before and after septal occlusion. Based on the measurement of cardiac flow vorticity in our implementation, we establish a relationship between atrial vorticity and septal defect. The developed system has the potential to be used as a prognostic and investigative tool for assessment of cardiac abnormalities, and can be exploited in parallel to examining myocardial defects using steady-state free precession magnetic resonance images of the heart.

Show MeSH
Related in: MedlinePlus