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My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

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Related in: MedlinePlus

Lymphangioleiomyomatosis. The cysts of lymphangioleiomyomatosis can be quite subtle in surgical lung biopsy samples. Once a cyst is identified, a search for thickened cellular areas of the wall will reveal the aggregated fascicles of hyperchromatic and slightly disorganised smooth muscle of lymphangioleiomyomatosis (inset). H&E stain, 15× original magnification; inset: 400× original magnification.
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CPT-62-05-0387-f31: Lymphangioleiomyomatosis. The cysts of lymphangioleiomyomatosis can be quite subtle in surgical lung biopsy samples. Once a cyst is identified, a search for thickened cellular areas of the wall will reveal the aggregated fascicles of hyperchromatic and slightly disorganised smooth muscle of lymphangioleiomyomatosis (inset). H&E stain, 15× original magnification; inset: 400× original magnification.

Mentions: Lymphangioleiomyomatosis is the prototype cystic lung disease which can be quite subtle in surgical lung biopsy samples. In well-prepared specimens (best achieved by removing the staples and then shaking the wedge specimen in fixative before sectioning), the cysts will be apparent at scanning magnification. Once identified, a search for thickened cellular areas of the cyst wall is often fruitful (fig 31). Immunohistochemical stains (HMB-45, Melan-A, oestrogen and progesterone receptors) are sometimes helpful in identifying the abnormal smooth muscle in this disorder.


My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Lymphangioleiomyomatosis. The cysts of lymphangioleiomyomatosis can be quite subtle in surgical lung biopsy samples. Once a cyst is identified, a search for thickened cellular areas of the wall will reveal the aggregated fascicles of hyperchromatic and slightly disorganised smooth muscle of lymphangioleiomyomatosis (inset). H&E stain, 15× original magnification; inset: 400× original magnification.
© Copyright Policy - openaccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2668105&req=5

CPT-62-05-0387-f31: Lymphangioleiomyomatosis. The cysts of lymphangioleiomyomatosis can be quite subtle in surgical lung biopsy samples. Once a cyst is identified, a search for thickened cellular areas of the wall will reveal the aggregated fascicles of hyperchromatic and slightly disorganised smooth muscle of lymphangioleiomyomatosis (inset). H&E stain, 15× original magnification; inset: 400× original magnification.
Mentions: Lymphangioleiomyomatosis is the prototype cystic lung disease which can be quite subtle in surgical lung biopsy samples. In well-prepared specimens (best achieved by removing the staples and then shaking the wedge specimen in fixative before sectioning), the cysts will be apparent at scanning magnification. Once identified, a search for thickened cellular areas of the cyst wall is often fruitful (fig 31). Immunohistochemical stains (HMB-45, Melan-A, oestrogen and progesterone receptors) are sometimes helpful in identifying the abnormal smooth muscle in this disorder.

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

Show MeSH
Related in: MedlinePlus