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My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

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Related in: MedlinePlus

Cryptogenic organising pneumonia (COP). The most consistent finding in COP is patchy involvement of the airspaces by small tufts of immature fibroblasts distributed within terminal bronchioles, alveolar ducts and alveoli. H&E stain, 40× original magnification.
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CPT-62-05-0387-f20: Cryptogenic organising pneumonia (COP). The most consistent finding in COP is patchy involvement of the airspaces by small tufts of immature fibroblasts distributed within terminal bronchioles, alveolar ducts and alveoli. H&E stain, 40× original magnification.

Mentions: OP is seen in a number of settings (see below), most notably in COP, a form of idiopathic ILD.31 The most consistent finding in COP is patchy involvement of the airspaces by small tufts of immature fibroblasts distributed within terminal bronchioles, alveolar ducts and alveoli (fig 20). Other findings that may accompany an OP pattern include interstitial infiltrates of mononuclear cells, fibrinous exudates, foam cells in the airspaces and prominent type II pneumocytes. Common causes of an OP pattern are presented in box 5.


My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Cryptogenic organising pneumonia (COP). The most consistent finding in COP is patchy involvement of the airspaces by small tufts of immature fibroblasts distributed within terminal bronchioles, alveolar ducts and alveoli. H&E stain, 40× original magnification.
© Copyright Policy - openaccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2668105&req=5

CPT-62-05-0387-f20: Cryptogenic organising pneumonia (COP). The most consistent finding in COP is patchy involvement of the airspaces by small tufts of immature fibroblasts distributed within terminal bronchioles, alveolar ducts and alveoli. H&E stain, 40× original magnification.
Mentions: OP is seen in a number of settings (see below), most notably in COP, a form of idiopathic ILD.31 The most consistent finding in COP is patchy involvement of the airspaces by small tufts of immature fibroblasts distributed within terminal bronchioles, alveolar ducts and alveoli (fig 20). Other findings that may accompany an OP pattern include interstitial infiltrates of mononuclear cells, fibrinous exudates, foam cells in the airspaces and prominent type II pneumocytes. Common causes of an OP pattern are presented in box 5.

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

Show MeSH
Related in: MedlinePlus