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My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

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Langerhans cell histiocytosis (LCH). The star-shaped, airway-centred scars of LCH are distinctive and may be a sign of resolved disease. H&E stain, 15× original magnification.
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CPT-62-05-0387-f14: Langerhans cell histiocytosis (LCH). The star-shaped, airway-centred scars of LCH are distinctive and may be a sign of resolved disease. H&E stain, 15× original magnification.

Mentions: The late stages of the smoking-related lung disease known as Langerhans cell histiocytosis (LCH) are characterised by the presence of stellate parenchymal scars (fig 14).24 These scars are distinctive and typically have few or no residual Langerhans cells. We refer to these as “healed” lesions of LCH. They may be incidental when the biopsy is performed for localised disease (such as carcinoma). In the setting of ILD, a form of “smoking-related interstitial lung disease” should be considered as the correct diagnosis.


My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Langerhans cell histiocytosis (LCH). The star-shaped, airway-centred scars of LCH are distinctive and may be a sign of resolved disease. H&E stain, 15× original magnification.
© Copyright Policy - openaccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2668105&req=5

CPT-62-05-0387-f14: Langerhans cell histiocytosis (LCH). The star-shaped, airway-centred scars of LCH are distinctive and may be a sign of resolved disease. H&E stain, 15× original magnification.
Mentions: The late stages of the smoking-related lung disease known as Langerhans cell histiocytosis (LCH) are characterised by the presence of stellate parenchymal scars (fig 14).24 These scars are distinctive and typically have few or no residual Langerhans cells. We refer to these as “healed” lesions of LCH. They may be incidental when the biopsy is performed for localised disease (such as carcinoma). In the setting of ILD, a form of “smoking-related interstitial lung disease” should be considered as the correct diagnosis.

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

Show MeSH
Related in: MedlinePlus