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My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

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Related in: MedlinePlus

Acute eosinophilic pneumonia. (A) When many eosinophils are visible in the airspaces in a patient with acute lung disease, a diagnosis of acute eosinophilic pneumonia is appropriate. (B) Organisation in alveolar spaces, and rarely hyaline membranes, may be present. (A,B) H&E stain, 100× original magnification.
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CPT-62-05-0387-f04: Acute eosinophilic pneumonia. (A) When many eosinophils are visible in the airspaces in a patient with acute lung disease, a diagnosis of acute eosinophilic pneumonia is appropriate. (B) Organisation in alveolar spaces, and rarely hyaline membranes, may be present. (A,B) H&E stain, 100× original magnification.

Mentions: Tissue eosinophils play important roles in a number of toxic, infectious and immunological lung reactions.11 When many eosinophils are visible in the airspaces (fig 4) in a patient with acute lung disease, a diagnosis of acute eosinophilic pneumonia is appropriate.12 This finding is a vital key to potentially reversible disease and should never be discounted or overlooked. Potential causes of eosinophilic pneumonia are presented in box 2.


My approach to interstitial lung disease using clinical, radiological and histopathological patterns.

Leslie KO - J. Clin. Pathol. (2009)

Acute eosinophilic pneumonia. (A) When many eosinophils are visible in the airspaces in a patient with acute lung disease, a diagnosis of acute eosinophilic pneumonia is appropriate. (B) Organisation in alveolar spaces, and rarely hyaline membranes, may be present. (A,B) H&E stain, 100× original magnification.
© Copyright Policy - openaccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2668105&req=5

CPT-62-05-0387-f04: Acute eosinophilic pneumonia. (A) When many eosinophils are visible in the airspaces in a patient with acute lung disease, a diagnosis of acute eosinophilic pneumonia is appropriate. (B) Organisation in alveolar spaces, and rarely hyaline membranes, may be present. (A,B) H&E stain, 100× original magnification.
Mentions: Tissue eosinophils play important roles in a number of toxic, infectious and immunological lung reactions.11 When many eosinophils are visible in the airspaces (fig 4) in a patient with acute lung disease, a diagnosis of acute eosinophilic pneumonia is appropriate.12 This finding is a vital key to potentially reversible disease and should never be discounted or overlooked. Potential causes of eosinophilic pneumonia are presented in box 2.

Bottom Line: The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting.The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis.A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

View Article: PubMed Central - PubMed

Affiliation: Division of Anatomic Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. leslie.kevin@mayo.edu

ABSTRACT
The complex world of interstitial lung disease presents nearly insurmountable challenges to the general surgical pathologist faced with a lung biopsy in this setting. The pathology is often inflammatory and always requires clinical and radiological context for a relevant and clinically useful histopathological diagnosis. A pattern-based histopathological approach to interstitial lung disease provides a "map" for the general pathologist to navigate this area successfully, especially so when used with aid of the clinical and radiological patterns of presentation.

Show MeSH
Related in: MedlinePlus