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Surgical inflammation: a pathophysiological rainbow.

Arias JI, Aller MA, Arias J - J Transl Med (2009)

Bottom Line: Tetrapyrrole molecules are distributed in virtually all living organisms on Earth.In mammals, tetrapyrrole end products are closely linked to oxygen metabolism.Therefore, the need of exploiting this color resource could be considered for both the diagnosis and treatment of the inflammation.

View Article: PubMed Central - HTML - PubMed

Affiliation: General Surgery Unit, Monte Naranco Hospital, Oviedo, Asturias, Spain. joseignacio-arias@sespa.princast.es

ABSTRACT
Tetrapyrrole molecules are distributed in virtually all living organisms on Earth. In mammals, tetrapyrrole end products are closely linked to oxygen metabolism. Since increasingly complex trophic functional systems for using oxygen are considered in the post-traumatic inflammatory response, it can be suggested that tetrapyrrole molecules and, particularly their derived pigments, play a key role in modulating inflammation.In this way, the diverse colorfulness that the inflammatory response triggers during its evolution would reflect the major pathophysiological importance of these pigments in each one of its phases. Therefore, the need of exploiting this color resource could be considered for both the diagnosis and treatment of the inflammation.

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Related in: MedlinePlus

Phases of the post-traumatic inflammatory response. The post-traumatic inflammatory response is considered to be made up of three overlapping phases with increasingly complex trophic functional systems for using oxygen. During the first or nervous phase, oxidative and nitrosative stress are produced. In the second or immune phase, enzymatic stress is produced and in the third or endocrine phase, oxidative phosphorylation is reached and therefore, energetic stress is produced. N: Nervous phase with oxidative stress and edema which progressively subsides(blue). I: Immune phase with enzymatic stress and its subsequent neutralization(yellow). E: Endocrine phase with its initial tissue de-structuring and subsequent tissue repair through regeneration and/or fibroplasia.(red).
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Figure 3: Phases of the post-traumatic inflammatory response. The post-traumatic inflammatory response is considered to be made up of three overlapping phases with increasingly complex trophic functional systems for using oxygen. During the first or nervous phase, oxidative and nitrosative stress are produced. In the second or immune phase, enzymatic stress is produced and in the third or endocrine phase, oxidative phosphorylation is reached and therefore, energetic stress is produced. N: Nervous phase with oxidative stress and edema which progressively subsides(blue). I: Immune phase with enzymatic stress and its subsequent neutralization(yellow). E: Endocrine phase with its initial tissue de-structuring and subsequent tissue repair through regeneration and/or fibroplasia.(red).

Mentions: It could be considered that the acute post-traumatic inflammatory response is made up of three overlapping phases, whether local or systemic (Figure 3).


Surgical inflammation: a pathophysiological rainbow.

Arias JI, Aller MA, Arias J - J Transl Med (2009)

Phases of the post-traumatic inflammatory response. The post-traumatic inflammatory response is considered to be made up of three overlapping phases with increasingly complex trophic functional systems for using oxygen. During the first or nervous phase, oxidative and nitrosative stress are produced. In the second or immune phase, enzymatic stress is produced and in the third or endocrine phase, oxidative phosphorylation is reached and therefore, energetic stress is produced. N: Nervous phase with oxidative stress and edema which progressively subsides(blue). I: Immune phase with enzymatic stress and its subsequent neutralization(yellow). E: Endocrine phase with its initial tissue de-structuring and subsequent tissue repair through regeneration and/or fibroplasia.(red).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2667492&req=5

Figure 3: Phases of the post-traumatic inflammatory response. The post-traumatic inflammatory response is considered to be made up of three overlapping phases with increasingly complex trophic functional systems for using oxygen. During the first or nervous phase, oxidative and nitrosative stress are produced. In the second or immune phase, enzymatic stress is produced and in the third or endocrine phase, oxidative phosphorylation is reached and therefore, energetic stress is produced. N: Nervous phase with oxidative stress and edema which progressively subsides(blue). I: Immune phase with enzymatic stress and its subsequent neutralization(yellow). E: Endocrine phase with its initial tissue de-structuring and subsequent tissue repair through regeneration and/or fibroplasia.(red).
Mentions: It could be considered that the acute post-traumatic inflammatory response is made up of three overlapping phases, whether local or systemic (Figure 3).

Bottom Line: Tetrapyrrole molecules are distributed in virtually all living organisms on Earth.In mammals, tetrapyrrole end products are closely linked to oxygen metabolism.Therefore, the need of exploiting this color resource could be considered for both the diagnosis and treatment of the inflammation.

View Article: PubMed Central - HTML - PubMed

Affiliation: General Surgery Unit, Monte Naranco Hospital, Oviedo, Asturias, Spain. joseignacio-arias@sespa.princast.es

ABSTRACT
Tetrapyrrole molecules are distributed in virtually all living organisms on Earth. In mammals, tetrapyrrole end products are closely linked to oxygen metabolism. Since increasingly complex trophic functional systems for using oxygen are considered in the post-traumatic inflammatory response, it can be suggested that tetrapyrrole molecules and, particularly their derived pigments, play a key role in modulating inflammation.In this way, the diverse colorfulness that the inflammatory response triggers during its evolution would reflect the major pathophysiological importance of these pigments in each one of its phases. Therefore, the need of exploiting this color resource could be considered for both the diagnosis and treatment of the inflammation.

Show MeSH
Related in: MedlinePlus