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Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases.

Kalinchenko S, Zemlyanoy A, Gooren LJ - Cardiovasc Diabetol (2009)

Bottom Line: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus.There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.The wound showed granulation.

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Affiliation: Russian Research Center for Endocrinology, Moscow, Russia. Kalinchenko@list.ru

ABSTRACT

Background: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus. There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.

Methods: We report the beneficial effects of administration of testosterone to three men with a diabetic foot whose serum testosterone was subnormal.

Results: Upon normalization of serum testosterone there was an improvement of hyperglycemia, a decrease of leukocytes and of fibrinogen levels, an increase of antithrombin III activity and of tissue oxygen pressure. The wound showed granulation.

Conclusion: Beneficial effects of administration of testosterone to hypogonadal with a diabetic foot may be due to improved vascularization and to anti-inflammatory action.

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Patient # 3 before administration of testosterone.
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Figure 5: Patient # 3 before administration of testosterone.

Mentions: Patient # 3, a 73 year-old man, presented with the diagnosis: type 2 diabetes, diabetic foot, neuroischemic form. Gangrene of the left foot. Atherosclerotic occlusion of femoropopliteal segment. Critical ischemia of the left foot. Coronary heart disease. (figure 5).


Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases.

Kalinchenko S, Zemlyanoy A, Gooren LJ - Cardiovasc Diabetol (2009)

Patient # 3 before administration of testosterone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2667490&req=5

Figure 5: Patient # 3 before administration of testosterone.
Mentions: Patient # 3, a 73 year-old man, presented with the diagnosis: type 2 diabetes, diabetic foot, neuroischemic form. Gangrene of the left foot. Atherosclerotic occlusion of femoropopliteal segment. Critical ischemia of the left foot. Coronary heart disease. (figure 5).

Bottom Line: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus.There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.The wound showed granulation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Russian Research Center for Endocrinology, Moscow, Russia. Kalinchenko@list.ru

ABSTRACT

Background: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus. There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.

Methods: We report the beneficial effects of administration of testosterone to three men with a diabetic foot whose serum testosterone was subnormal.

Results: Upon normalization of serum testosterone there was an improvement of hyperglycemia, a decrease of leukocytes and of fibrinogen levels, an increase of antithrombin III activity and of tissue oxygen pressure. The wound showed granulation.

Conclusion: Beneficial effects of administration of testosterone to hypogonadal with a diabetic foot may be due to improved vascularization and to anti-inflammatory action.

Show MeSH
Related in: MedlinePlus