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Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases.

Kalinchenko S, Zemlyanoy A, Gooren LJ - Cardiovasc Diabetol (2009)

Bottom Line: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus.There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.The wound showed granulation.

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Affiliation: Russian Research Center for Endocrinology, Moscow, Russia. Kalinchenko@list.ru

ABSTRACT

Background: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus. There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.

Methods: We report the beneficial effects of administration of testosterone to three men with a diabetic foot whose serum testosterone was subnormal.

Results: Upon normalization of serum testosterone there was an improvement of hyperglycemia, a decrease of leukocytes and of fibrinogen levels, an increase of antithrombin III activity and of tissue oxygen pressure. The wound showed granulation.

Conclusion: Beneficial effects of administration of testosterone to hypogonadal with a diabetic foot may be due to improved vascularization and to anti-inflammatory action.

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Patient # 1 after administration of testosterone.
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Figure 2: Patient # 1 after administration of testosterone.

Mentions: Results of investigations 17 days after injection of TU: decrease of leukocyte count (5.6 × 109/L), plasma glucose level (6.8 mmol/L), fibrinogen level (5.0 g/L), increased antithrombin III activity (93%), increase of TpO2 (18 mm Hg). The wound showed now granulation (figure 2). Plasma glucose level remained stable within the range of 6–8 mmol/L.


Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three cases.

Kalinchenko S, Zemlyanoy A, Gooren LJ - Cardiovasc Diabetol (2009)

Patient # 1 after administration of testosterone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2667490&req=5

Figure 2: Patient # 1 after administration of testosterone.
Mentions: Results of investigations 17 days after injection of TU: decrease of leukocyte count (5.6 × 109/L), plasma glucose level (6.8 mmol/L), fibrinogen level (5.0 g/L), increased antithrombin III activity (93%), increase of TpO2 (18 mm Hg). The wound showed now granulation (figure 2). Plasma glucose level remained stable within the range of 6–8 mmol/L.

Bottom Line: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus.There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.The wound showed granulation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Russian Research Center for Endocrinology, Moscow, Russia. Kalinchenko@list.ru

ABSTRACT

Background: Lower extremity complications (neuropathy, ulceration, infection, and peripheral arterial disease) are common in diabetes mellitus. There is an inverse relation between plasma testosterone and insulin sensitivity, type 2 diabetes mellitus and HbA1c concentrations.

Methods: We report the beneficial effects of administration of testosterone to three men with a diabetic foot whose serum testosterone was subnormal.

Results: Upon normalization of serum testosterone there was an improvement of hyperglycemia, a decrease of leukocytes and of fibrinogen levels, an increase of antithrombin III activity and of tissue oxygen pressure. The wound showed granulation.

Conclusion: Beneficial effects of administration of testosterone to hypogonadal with a diabetic foot may be due to improved vascularization and to anti-inflammatory action.

Show MeSH
Related in: MedlinePlus