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Development of an integrated suite of software in analysing of large DNA databases.

Kong KS, Ng EY - Open Med Inform J (2008)

Bottom Line: The integrated software tool has great potential and that the results obtained during the tests were satisfactory.The recent South Asia Tsunami incident has renewed the need to establish a quick and reliable system for DNA matching and comparison.Fault tolerance enhancement to the system is one of the key areas that can further help to make the entire application efficient, robust and reliable.

View Article: PubMed Central - PubMed

Affiliation: DS Center/IEP, DSO National Laboratories, 20 Science Park Drive, Singapore 118230.

ABSTRACT
The work showed that the integrated suite of software tools for detecting criminals using DNA databases has achieved the overall objective by providing a working platform for sequence analysis. The work also demonstrated that by integrating BLAST and FASTA (two widely used and freely available algorithms), plus an additional implementation of PSA (custom-built pairwise sequence alignment algorithms) and TR analysis tools (for detecting tandem repeats) with the rest of the utilities supporting tools (databases and files management) developed, it is entirely possible to have an initial working version of the software tool for criminal DNA analysis and detection work. The integrated software tool has great potential and that the results obtained during the tests were satisfactory. The recent South Asia Tsunami incident has renewed the need to establish a quick and reliable system for DNA matching and comparison. This work may also contribute towards the quick identification of victims in many disasters.Future works are to further enhance the existing tools by adding more options and controls, improve upon the visualisation display, and to build robust software architecture to better manage the system loadings. Fault tolerance enhancement to the system is one of the key areas that can further help to make the entire application efficient, robust and reliable.

No MeSH data available.


Tandem Repeats Search Tool.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
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Figure 15: Tandem Repeats Search Tool.

Mentions: Fig. (15) depicts the GUI layout of the tandem repeats search tool. To upload a suspect’s DNA sequence, click on the “folder” button. A file selector dialog will be prompted. Enter a minimum and maximum word size for the TR search. Click on the “Enter” button to start analysing the DNA sequence. The TR algorithm will perform TR analysis on the sequence being entered. All the possible ETRs are displayed in the STR Word Text Area. For instance, “ATG (3)” means that “ATG” is found to be a continuous TR within the sequence and “(3)” means that there are three such TRs.


Development of an integrated suite of software in analysing of large DNA databases.

Kong KS, Ng EY - Open Med Inform J (2008)

Tandem Repeats Search Tool.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2666961&req=5

Figure 15: Tandem Repeats Search Tool.
Mentions: Fig. (15) depicts the GUI layout of the tandem repeats search tool. To upload a suspect’s DNA sequence, click on the “folder” button. A file selector dialog will be prompted. Enter a minimum and maximum word size for the TR search. Click on the “Enter” button to start analysing the DNA sequence. The TR algorithm will perform TR analysis on the sequence being entered. All the possible ETRs are displayed in the STR Word Text Area. For instance, “ATG (3)” means that “ATG” is found to be a continuous TR within the sequence and “(3)” means that there are three such TRs.

Bottom Line: The integrated software tool has great potential and that the results obtained during the tests were satisfactory.The recent South Asia Tsunami incident has renewed the need to establish a quick and reliable system for DNA matching and comparison.Fault tolerance enhancement to the system is one of the key areas that can further help to make the entire application efficient, robust and reliable.

View Article: PubMed Central - PubMed

Affiliation: DS Center/IEP, DSO National Laboratories, 20 Science Park Drive, Singapore 118230.

ABSTRACT
The work showed that the integrated suite of software tools for detecting criminals using DNA databases has achieved the overall objective by providing a working platform for sequence analysis. The work also demonstrated that by integrating BLAST and FASTA (two widely used and freely available algorithms), plus an additional implementation of PSA (custom-built pairwise sequence alignment algorithms) and TR analysis tools (for detecting tandem repeats) with the rest of the utilities supporting tools (databases and files management) developed, it is entirely possible to have an initial working version of the software tool for criminal DNA analysis and detection work. The integrated software tool has great potential and that the results obtained during the tests were satisfactory. The recent South Asia Tsunami incident has renewed the need to establish a quick and reliable system for DNA matching and comparison. This work may also contribute towards the quick identification of victims in many disasters.Future works are to further enhance the existing tools by adding more options and controls, improve upon the visualisation display, and to build robust software architecture to better manage the system loadings. Fault tolerance enhancement to the system is one of the key areas that can further help to make the entire application efficient, robust and reliable.

No MeSH data available.