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Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: an fMRI study.

Whalley MG, Rugg MD, Smith AP, Dolan RJ, Brewin CR - Brain Cogn (2008)

Bottom Line: In the study phase of the task neutral pictures were presented in emotional or neutral contexts.Activity common to all three groups when correctly judging pictures encoded in emotional contexts was much more limited.Relative to the control and depressed groups the PTSD group exhibited greater sensitivity to correctly recognised stimuli in the left amygdala/ventral striatum and right occipital cortex, and more specific sensitivity to items encoded in emotional contexts in the right precuneus, left superior frontal gyrus, and bilateral insula.

View Article: PubMed Central - PubMed

Affiliation: Sub-Department of Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, UK.

ABSTRACT
In the present study, we used fMRI to assess patients suffering from post-traumatic stress disorder (PTSD) or depression, and trauma-exposed controls, during an episodic memory retrieval task that included non-trauma-related emotional information. In the study phase of the task neutral pictures were presented in emotional or neutral contexts. Participants were scanned during the test phase, when they were presented with old and new neutral images in a yes/no recognition memory task. fMRI results for the contrast between old and new items revealed activation in a predominantly left-sided network of cortical regions including the left middle temporal, bilateral posterior cingulate, and left prefrontal cortices. Activity common to all three groups when correctly judging pictures encoded in emotional contexts was much more limited. Relative to the control and depressed groups the PTSD group exhibited greater sensitivity to correctly recognised stimuli in the left amygdala/ventral striatum and right occipital cortex, and more specific sensitivity to items encoded in emotional contexts in the right precuneus, left superior frontal gyrus, and bilateral insula. These results are consistent with a substantially intact neural system supporting episodic retrieval in patients suffering from PTSD. Moreover, there was little indication that PTSD is associated with a marked change in the way negatively valenced information, not of personal significance, is processed.

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Related in: MedlinePlus

Parameter estimates (arbitrary units) for regions demonstrating additional activity in the PTSD group relative to the control and depressed groups for the emotional hit > neutral hit contrast. Statistical parametric maps thresholded at p < .001 uncorrected.
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fig5: Parameter estimates (arbitrary units) for regions demonstrating additional activity in the PTSD group relative to the control and depressed groups for the emotional hit > neutral hit contrast. Statistical parametric maps thresholded at p < .001 uncorrected.

Mentions: For the emotional > neutral hit contrast the PTSD group demonstrated greater activity than the depressed or control groups in areas of the left putamen and hippocampus, right precuneus, mid-cingulate cortex and occipital cortex (see Fig. 5 and Table 4).


Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: an fMRI study.

Whalley MG, Rugg MD, Smith AP, Dolan RJ, Brewin CR - Brain Cogn (2008)

Parameter estimates (arbitrary units) for regions demonstrating additional activity in the PTSD group relative to the control and depressed groups for the emotional hit > neutral hit contrast. Statistical parametric maps thresholded at p < .001 uncorrected.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2666800&req=5

fig5: Parameter estimates (arbitrary units) for regions demonstrating additional activity in the PTSD group relative to the control and depressed groups for the emotional hit > neutral hit contrast. Statistical parametric maps thresholded at p < .001 uncorrected.
Mentions: For the emotional > neutral hit contrast the PTSD group demonstrated greater activity than the depressed or control groups in areas of the left putamen and hippocampus, right precuneus, mid-cingulate cortex and occipital cortex (see Fig. 5 and Table 4).

Bottom Line: In the study phase of the task neutral pictures were presented in emotional or neutral contexts.Activity common to all three groups when correctly judging pictures encoded in emotional contexts was much more limited.Relative to the control and depressed groups the PTSD group exhibited greater sensitivity to correctly recognised stimuli in the left amygdala/ventral striatum and right occipital cortex, and more specific sensitivity to items encoded in emotional contexts in the right precuneus, left superior frontal gyrus, and bilateral insula.

View Article: PubMed Central - PubMed

Affiliation: Sub-Department of Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, UK.

ABSTRACT
In the present study, we used fMRI to assess patients suffering from post-traumatic stress disorder (PTSD) or depression, and trauma-exposed controls, during an episodic memory retrieval task that included non-trauma-related emotional information. In the study phase of the task neutral pictures were presented in emotional or neutral contexts. Participants were scanned during the test phase, when they were presented with old and new neutral images in a yes/no recognition memory task. fMRI results for the contrast between old and new items revealed activation in a predominantly left-sided network of cortical regions including the left middle temporal, bilateral posterior cingulate, and left prefrontal cortices. Activity common to all three groups when correctly judging pictures encoded in emotional contexts was much more limited. Relative to the control and depressed groups the PTSD group exhibited greater sensitivity to correctly recognised stimuli in the left amygdala/ventral striatum and right occipital cortex, and more specific sensitivity to items encoded in emotional contexts in the right precuneus, left superior frontal gyrus, and bilateral insula. These results are consistent with a substantially intact neural system supporting episodic retrieval in patients suffering from PTSD. Moreover, there was little indication that PTSD is associated with a marked change in the way negatively valenced information, not of personal significance, is processed.

Show MeSH
Related in: MedlinePlus