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Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment.

Bernjak A, Clarkson PB, McClintock PV, Stefanovska A - Microvasc. Res. (2008)

Bottom Line: It is concluded that there are two oscillatory skin blood flow components associated with endothelial function.Both are reduced in CHF.Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Electrical Engineering, University of Ljubljana, Slovenia.

ABSTRACT
Laser Doppler flowmetry (LDF) of forearm skin blood flow, combined with iontophoretically-administered acetylcholine and sodium nitroprusside and wavelet spectral analysis, was used for noninvasive evaluation of endothelial function in 17 patients newly diagnosed with New York Heart Association class II-III congestive heart failure (CHF). After 20+/-10 weeks' treatment with a beta(1)-blocker (Bisoprolol), the measurements were repeated. Measurements were also made on an age- and sex-matched group of healthy controls (HC). In each case data were recorded for 30 min. In HC, the difference in absolute spectral amplitude of LDF oscillations between the two vasodilators manifests in the frequency interval 0.005-0.0095 Hz (p<0.01); this difference is initially absent in patients with CHF, but appears following the beta(1)-blocker treatment (p<0.01). For HC, the difference between the two vasodilators also manifests in normalised spectral amplitude in 0.0095-0.021 Hz (p<0.05). This latter difference is absent in CHF patients and is unchanged by treatment with beta(1)-blockers. It is concluded that there are two oscillatory skin blood flow components associated with endothelial function. Both are reduced in CHF. Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

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Comparison of the three subject groups (HC, CHF and CHF-β) in terms of their ACh and SNP responses. Absolute spectral amplitudes are presented in intervals V and VI for (a) ACh response and (b) SNP response. 0.01 < p < 0.05 is indicated by ⁎ and p < 0.01 by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).
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fig7: Comparison of the three subject groups (HC, CHF and CHF-β) in terms of their ACh and SNP responses. Absolute spectral amplitudes are presented in intervals V and VI for (a) ACh response and (b) SNP response. 0.01 < p < 0.05 is indicated by ⁎ and p < 0.01 by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).

Mentions: A nonpaired, nonparametric, Wilcoxon rank sum test was used to obtain the probability that two group distributions were equal (data presented in Figs. 4 and 5). A paired, Wilcoxon signed rank test was used to obtain the probability that the effect of two substances, ACh and SNP, was equal for a given group (data presented in Fig. 6). For hemodynamic data (Fig. 3) and skin temperature parametric t-tests were used, a nonpaired one in comparing patients with controls and a paired one between patient groups. Paired and nonpaired Wilcoxon tests were used to produce the statistics in Fig. 7. A nonpaired test was used to compare HC with patients before and after treatment, while a paired test was used to compare both patient groups.


Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment.

Bernjak A, Clarkson PB, McClintock PV, Stefanovska A - Microvasc. Res. (2008)

Comparison of the three subject groups (HC, CHF and CHF-β) in terms of their ACh and SNP responses. Absolute spectral amplitudes are presented in intervals V and VI for (a) ACh response and (b) SNP response. 0.01 < p < 0.05 is indicated by ⁎ and p < 0.01 by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2666799&req=5

fig7: Comparison of the three subject groups (HC, CHF and CHF-β) in terms of their ACh and SNP responses. Absolute spectral amplitudes are presented in intervals V and VI for (a) ACh response and (b) SNP response. 0.01 < p < 0.05 is indicated by ⁎ and p < 0.01 by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).
Mentions: A nonpaired, nonparametric, Wilcoxon rank sum test was used to obtain the probability that two group distributions were equal (data presented in Figs. 4 and 5). A paired, Wilcoxon signed rank test was used to obtain the probability that the effect of two substances, ACh and SNP, was equal for a given group (data presented in Fig. 6). For hemodynamic data (Fig. 3) and skin temperature parametric t-tests were used, a nonpaired one in comparing patients with controls and a paired one between patient groups. Paired and nonpaired Wilcoxon tests were used to produce the statistics in Fig. 7. A nonpaired test was used to compare HC with patients before and after treatment, while a paired test was used to compare both patient groups.

Bottom Line: It is concluded that there are two oscillatory skin blood flow components associated with endothelial function.Both are reduced in CHF.Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Electrical Engineering, University of Ljubljana, Slovenia.

ABSTRACT
Laser Doppler flowmetry (LDF) of forearm skin blood flow, combined with iontophoretically-administered acetylcholine and sodium nitroprusside and wavelet spectral analysis, was used for noninvasive evaluation of endothelial function in 17 patients newly diagnosed with New York Heart Association class II-III congestive heart failure (CHF). After 20+/-10 weeks' treatment with a beta(1)-blocker (Bisoprolol), the measurements were repeated. Measurements were also made on an age- and sex-matched group of healthy controls (HC). In each case data were recorded for 30 min. In HC, the difference in absolute spectral amplitude of LDF oscillations between the two vasodilators manifests in the frequency interval 0.005-0.0095 Hz (p<0.01); this difference is initially absent in patients with CHF, but appears following the beta(1)-blocker treatment (p<0.01). For HC, the difference between the two vasodilators also manifests in normalised spectral amplitude in 0.0095-0.021 Hz (p<0.05). This latter difference is absent in CHF patients and is unchanged by treatment with beta(1)-blockers. It is concluded that there are two oscillatory skin blood flow components associated with endothelial function. Both are reduced in CHF. Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

Show MeSH
Related in: MedlinePlus