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Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment.

Bernjak A, Clarkson PB, McClintock PV, Stefanovska A - Microvasc. Res. (2008)

Bottom Line: It is concluded that there are two oscillatory skin blood flow components associated with endothelial function.Both are reduced in CHF.Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Electrical Engineering, University of Ljubljana, Slovenia.

ABSTRACT
Laser Doppler flowmetry (LDF) of forearm skin blood flow, combined with iontophoretically-administered acetylcholine and sodium nitroprusside and wavelet spectral analysis, was used for noninvasive evaluation of endothelial function in 17 patients newly diagnosed with New York Heart Association class II-III congestive heart failure (CHF). After 20+/-10 weeks' treatment with a beta(1)-blocker (Bisoprolol), the measurements were repeated. Measurements were also made on an age- and sex-matched group of healthy controls (HC). In each case data were recorded for 30 min. In HC, the difference in absolute spectral amplitude of LDF oscillations between the two vasodilators manifests in the frequency interval 0.005-0.0095 Hz (p<0.01); this difference is initially absent in patients with CHF, but appears following the beta(1)-blocker treatment (p<0.01). For HC, the difference between the two vasodilators also manifests in normalised spectral amplitude in 0.0095-0.021 Hz (p<0.05). This latter difference is absent in CHF patients and is unchanged by treatment with beta(1)-blockers. It is concluded that there are two oscillatory skin blood flow components associated with endothelial function. Both are reduced in CHF. Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

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Related in: MedlinePlus

The effects of ACh and SNP on the mean value of the blood flow signal and the average spectral amplitude for the CHF and HC subject groups. p < 0.01 is indicated by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).
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fig4: The effects of ACh and SNP on the mean value of the blood flow signal and the average spectral amplitude for the CHF and HC subject groups. p < 0.01 is indicated by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).

Mentions: Effect of ACh and SNP on mean value of the LDF signal and average spectral amplitude: a comparison of the HC and CHF groups' responses to ACh and SNP is presented in Fig. 4: (a) shows mean blood flow and (b) the average spectral amplitude. There are highly significant differences in the mean flows between these two subject groups, in their responses to both ACh and SNP. However, there are no statistically significant differences between them in the average spectral amplitudes of their responses to ACh and SNP.


Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment.

Bernjak A, Clarkson PB, McClintock PV, Stefanovska A - Microvasc. Res. (2008)

The effects of ACh and SNP on the mean value of the blood flow signal and the average spectral amplitude for the CHF and HC subject groups. p < 0.01 is indicated by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2666799&req=5

fig4: The effects of ACh and SNP on the mean value of the blood flow signal and the average spectral amplitude for the CHF and HC subject groups. p < 0.01 is indicated by ⁎⁎. For an explanation of data presentation and error bars, see text (subsection on statistical analysis and presentation).
Mentions: Effect of ACh and SNP on mean value of the LDF signal and average spectral amplitude: a comparison of the HC and CHF groups' responses to ACh and SNP is presented in Fig. 4: (a) shows mean blood flow and (b) the average spectral amplitude. There are highly significant differences in the mean flows between these two subject groups, in their responses to both ACh and SNP. However, there are no statistically significant differences between them in the average spectral amplitudes of their responses to ACh and SNP.

Bottom Line: It is concluded that there are two oscillatory skin blood flow components associated with endothelial function.Both are reduced in CHF.Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Faculty of Electrical Engineering, University of Ljubljana, Slovenia.

ABSTRACT
Laser Doppler flowmetry (LDF) of forearm skin blood flow, combined with iontophoretically-administered acetylcholine and sodium nitroprusside and wavelet spectral analysis, was used for noninvasive evaluation of endothelial function in 17 patients newly diagnosed with New York Heart Association class II-III congestive heart failure (CHF). After 20+/-10 weeks' treatment with a beta(1)-blocker (Bisoprolol), the measurements were repeated. Measurements were also made on an age- and sex-matched group of healthy controls (HC). In each case data were recorded for 30 min. In HC, the difference in absolute spectral amplitude of LDF oscillations between the two vasodilators manifests in the frequency interval 0.005-0.0095 Hz (p<0.01); this difference is initially absent in patients with CHF, but appears following the beta(1)-blocker treatment (p<0.01). For HC, the difference between the two vasodilators also manifests in normalised spectral amplitude in 0.0095-0.021 Hz (p<0.05). This latter difference is absent in CHF patients and is unchanged by treatment with beta(1)-blockers. It is concluded that there are two oscillatory skin blood flow components associated with endothelial function. Both are reduced in CHF. Activity in the lower frequency interval is restored by beta(1)-blocker treatment, confirming the association between CHF and endothelial dysfunction but suggesting the involvement of two distinct mechanisms.

Show MeSH
Related in: MedlinePlus