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Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man.

Akerman U, Edvinsson L - BMC Res Notes (2009)

Bottom Line: There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration.The median maximal paracetamol concentration was 147 mumol/l for water, which is significantly higher than the median for rosehip drink with Lp299v,113.5 mumol/l, and than the median for rosehip-drink without Lp299v, 106.5 mumol/l (p = 0.002, and p = 0.003); there were no significant difference between rosehip drink with or without Lp299v (p > 0.3).This may in the clinic translate to the use of more drug than it is necessary.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Emergency Medicine, Clinical Sciences, University Hospital, Lund, Sweden. ulrika.akerman@skane.se

ABSTRACT

Background: Clinical observations have revealed that patients throw up undigested paracetamol tablets several hours following intake of rosehip drink with Lp299v (Proviva). The purpose of this study was to demonstrate if this translates into altered plasma levels of paracetamol in nineteen healthy subjects consuming 200 ml of water, Rose hip drink or Proviva together with 1.5 gram of paracetamol.

Findings: The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 mumol/l was reached (a 95% confidence interval of 57,161). The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 mumol/l (95% confidence intervals contain only zero for both rosehip treatments). There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration. The median maximal paracetamol concentration was 147 mumol/l for water, which is significantly higher than the median for rosehip drink with Lp299v,113.5 mumol/l, and than the median for rosehip-drink without Lp299v, 106.5 mumol/l (p = 0.002, and p = 0.003); there were no significant difference between rosehip drink with or without Lp299v (p > 0.3).

Conclusion: We have demonstrated an interaction between the uptake of paracetamol and the solvent in rosehip drink/Provia which mainly consists of long chain carbohydrates. This may in the clinic translate to the use of more drug than it is necessary.

No MeSH data available.


Median of concentration of paracetamol in blood serum. Error bars represent 95% confidence intervals for the median based on the measurements at that point.
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Figure 1: Median of concentration of paracetamol in blood serum. Error bars represent 95% confidence intervals for the median based on the measurements at that point.

Mentions: There were large individual variations in the plasma levels of paracetamol, however, the general pattern was that most subjects had a larger AUC, a higher maximum level and shorter time to maximum when the tablets were ingested with water. The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 μmol/l was reached (Figure 1), with a 95% confidence interval of (57,161). The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 μmol/l where the 95% confidence intervals contain only zero for both rosehip treatments. There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration (p < 0.001 for AUC, p = 0.014 for maximum concentration and p < 0.001 for time to maximum according to Friedman's test). The median maximal paracetamol concentration was 147 μmol/l for water, which was significantly higher than the median for rosehip drink with Lp299v,113.5 μmol/l, and than the median for rosehip-drink without Lp299v, 106.5 μmol/l (p = 0.002, and p = 0.003) (Table 1), but there were no significant differences between rosehip drink with or without Lp299v (p > 0.3). The AUC values also differed (Table 1, p < 0.001, Friedman's test) and this was mainly because the rosehip drinks gave a lower paracetamol concentration up to 90 minutes after the start, whereas the paracetamol concentrations were similar for the three treatments in the interval 120–300 minutes (Figure 1). Post hoc tests showed significant differences between water and rosehip drink (p = 0.001), water and rosehip drink with Lp299v (p < 0.001), but no difference between rosehip drinks with or without Lp299v (p > 0.3).


Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man.

Akerman U, Edvinsson L - BMC Res Notes (2009)

Median of concentration of paracetamol in blood serum. Error bars represent 95% confidence intervals for the median based on the measurements at that point.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2666754&req=5

Figure 1: Median of concentration of paracetamol in blood serum. Error bars represent 95% confidence intervals for the median based on the measurements at that point.
Mentions: There were large individual variations in the plasma levels of paracetamol, however, the general pattern was that most subjects had a larger AUC, a higher maximum level and shorter time to maximum when the tablets were ingested with water. The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 μmol/l was reached (Figure 1), with a 95% confidence interval of (57,161). The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 μmol/l where the 95% confidence intervals contain only zero for both rosehip treatments. There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration (p < 0.001 for AUC, p = 0.014 for maximum concentration and p < 0.001 for time to maximum according to Friedman's test). The median maximal paracetamol concentration was 147 μmol/l for water, which was significantly higher than the median for rosehip drink with Lp299v,113.5 μmol/l, and than the median for rosehip-drink without Lp299v, 106.5 μmol/l (p = 0.002, and p = 0.003) (Table 1), but there were no significant differences between rosehip drink with or without Lp299v (p > 0.3). The AUC values also differed (Table 1, p < 0.001, Friedman's test) and this was mainly because the rosehip drinks gave a lower paracetamol concentration up to 90 minutes after the start, whereas the paracetamol concentrations were similar for the three treatments in the interval 120–300 minutes (Figure 1). Post hoc tests showed significant differences between water and rosehip drink (p = 0.001), water and rosehip drink with Lp299v (p < 0.001), but no difference between rosehip drinks with or without Lp299v (p > 0.3).

Bottom Line: There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration.The median maximal paracetamol concentration was 147 mumol/l for water, which is significantly higher than the median for rosehip drink with Lp299v,113.5 mumol/l, and than the median for rosehip-drink without Lp299v, 106.5 mumol/l (p = 0.002, and p = 0.003); there were no significant difference between rosehip drink with or without Lp299v (p > 0.3).This may in the clinic translate to the use of more drug than it is necessary.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Emergency Medicine, Clinical Sciences, University Hospital, Lund, Sweden. ulrika.akerman@skane.se

ABSTRACT

Background: Clinical observations have revealed that patients throw up undigested paracetamol tablets several hours following intake of rosehip drink with Lp299v (Proviva). The purpose of this study was to demonstrate if this translates into altered plasma levels of paracetamol in nineteen healthy subjects consuming 200 ml of water, Rose hip drink or Proviva together with 1.5 gram of paracetamol.

Findings: The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 mumol/l was reached (a 95% confidence interval of 57,161). The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 mumol/l (95% confidence intervals contain only zero for both rosehip treatments). There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration. The median maximal paracetamol concentration was 147 mumol/l for water, which is significantly higher than the median for rosehip drink with Lp299v,113.5 mumol/l, and than the median for rosehip-drink without Lp299v, 106.5 mumol/l (p = 0.002, and p = 0.003); there were no significant difference between rosehip drink with or without Lp299v (p > 0.3).

Conclusion: We have demonstrated an interaction between the uptake of paracetamol and the solvent in rosehip drink/Provia which mainly consists of long chain carbohydrates. This may in the clinic translate to the use of more drug than it is necessary.

No MeSH data available.