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Assessment of anti-cyclic citrullinated peptide in psoriatic arthritis.

Abdel Fattah NS, Hassan HE, Galal ZA, El Okda el SE - BMC Res Notes (2009)

Bottom Line: Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA.Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA.Anti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. nermeensamy2000@yahoo.com

ABSTRACT

Background: Anti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as regards clinical and radiological associations. The current study assessed anti-CCP in PsA and determined its clinical and radiological associations.

Methods: Four groups contributed to this study. 40 PsA, 40 psoriasis without arthritis, 40 RA and 40 healthy controls. They were tested for anti-CCP. Clinical and radiological data were collected and statistically compared between anti-CCP-positive and -negative PsA patients.

Results: Seven PsA (17.5%) and 34 RA (85%) were seropositive for anti-CCP. Patients of other groups were anti-CCP-negative. Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA. Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA.

Conclusion: Anti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis.

No MeSH data available.


Related in: MedlinePlus

Mean anti-CCP concentrations of studied groups.
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Figure 1: Mean anti-CCP concentrations of studied groups.

Mentions: As regards anti-CCP, 7/40 PsA (17.5%) and 34/40 RA patients (85%) were seropositive with respect to the cut-off value. Patients with psoriasis without arthritis and healthy controls showed anti-CCP concentrations below cut-off value (anti-CCP-negative). On comparing the different groups together, statistically highly significant difference was found (table 2). As regards anti-CCP concentrations (Figure 1), statistically highly significant difference existed between the different studied groups (table 3) as well as between anti-CCP-positive PsA, anti-CCP-negative PsA, psoriasis without arthritis and healthy controls (table 4). Post-hoc test revealed significant differences between PsA and psoriasis without arthritis (P = 0.012) and between PsA and healthy controls (P = 0.010). Statistically highly significant differences were found between RA and PsA, between RA and psoriasis without arthritis, between RA and healthy controls and between anti-CCP-positive and -negative PsA patients (P = 0.001). On the other hand, no statistical difference was present between anti-CCP-positive PsA and RA (P = 0.1464), and between psoriasis without arthritis and healthy controls (0.848).


Assessment of anti-cyclic citrullinated peptide in psoriatic arthritis.

Abdel Fattah NS, Hassan HE, Galal ZA, El Okda el SE - BMC Res Notes (2009)

Mean anti-CCP concentrations of studied groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2666753&req=5

Figure 1: Mean anti-CCP concentrations of studied groups.
Mentions: As regards anti-CCP, 7/40 PsA (17.5%) and 34/40 RA patients (85%) were seropositive with respect to the cut-off value. Patients with psoriasis without arthritis and healthy controls showed anti-CCP concentrations below cut-off value (anti-CCP-negative). On comparing the different groups together, statistically highly significant difference was found (table 2). As regards anti-CCP concentrations (Figure 1), statistically highly significant difference existed between the different studied groups (table 3) as well as between anti-CCP-positive PsA, anti-CCP-negative PsA, psoriasis without arthritis and healthy controls (table 4). Post-hoc test revealed significant differences between PsA and psoriasis without arthritis (P = 0.012) and between PsA and healthy controls (P = 0.010). Statistically highly significant differences were found between RA and PsA, between RA and psoriasis without arthritis, between RA and healthy controls and between anti-CCP-positive and -negative PsA patients (P = 0.001). On the other hand, no statistical difference was present between anti-CCP-positive PsA and RA (P = 0.1464), and between psoriasis without arthritis and healthy controls (0.848).

Bottom Line: Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA.Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA.Anti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. nermeensamy2000@yahoo.com

ABSTRACT

Background: Anti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as regards clinical and radiological associations. The current study assessed anti-CCP in PsA and determined its clinical and radiological associations.

Methods: Four groups contributed to this study. 40 PsA, 40 psoriasis without arthritis, 40 RA and 40 healthy controls. They were tested for anti-CCP. Clinical and radiological data were collected and statistically compared between anti-CCP-positive and -negative PsA patients.

Results: Seven PsA (17.5%) and 34 RA (85%) were seropositive for anti-CCP. Patients of other groups were anti-CCP-negative. Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA. Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA.

Conclusion: Anti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis.

No MeSH data available.


Related in: MedlinePlus