Limits...
Genomic scan for quantitative trait loci of chemical and physical body composition and deposition on pig chromosome X including the pseudoautosomal region of males.

Duthie CA, Simm G, Pérez-Enciso M, Doeschl-Wilson A, Kalm E, Knap PW, Roehe R - Genet. Sel. Evol. (2009)

Bottom Line: A three-generation full-sib population of 386 animals was created by crossing Pietrain sires with a crossbred dam line.Several significant and suggestive QTL were detected on pig chromosome X: (1) in the pseudoautosomal region of SSCX, a QTL for entire loin weight, which showed paternal imprinting, (2) closely linked to marker SW2456, a suggestive QTL for feed intake at which Pietrain alleles were found to be associated with higher feed intake, which is unexpected for a breed known for its low feed intake capacity, (3) at the telomeric end of the q arm of SSCX, QTL for jowl weight and lipid accretion and (4) suggestive QTL for chemical body composition at 30 kg.These results indicate that SSCX is important for physical and chemical body composition and accretion as well as feed intake regulation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Animal Breeding and Development, Sustainable Livestock Systems Group, Scottish Agricultural College, West Mains Road, Edinburgh, UK. Carol-Anne.Duthie@sac.ac.uk

ABSTRACT
A QTL analysis of pig chromosome X (SSCX) was carried out using an approach that accurately takes into account the specific features of sex chromosomes i.e. their heterogeneity, the presence of a pseudoautosomal region and the dosage compensation phenomenon. A three-generation full-sib population of 386 animals was created by crossing Pietrain sires with a crossbred dam line. Phenotypic data on 72 traits were recorded for at least 292 and up to 315 F2 animals including chemical body composition measured on live animals at five target weights ranging from 30 to 140 kg, daily gain and feed intake measured throughout growth, and carcass characteristics obtained at slaughter weight (140 kg). Several significant and suggestive QTL were detected on pig chromosome X: (1) in the pseudoautosomal region of SSCX, a QTL for entire loin weight, which showed paternal imprinting, (2) closely linked to marker SW2456, a suggestive QTL for feed intake at which Pietrain alleles were found to be associated with higher feed intake, which is unexpected for a breed known for its low feed intake capacity, (3) at the telomeric end of the q arm of SSCX, QTL for jowl weight and lipid accretion and (4) suggestive QTL for chemical body composition at 30 kg. These results indicate that SSCX is important for physical and chemical body composition and accretion as well as feed intake regulation.

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Likelihood ratio curves for evidence of suggestive quantitative trait loci for loin weight without external fat, protein content of the empty body at 30 kg body weight and daily feed intake (DFI) 120–140 kg on SSCX. Positions in cM are based on the USDA reference map.
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Figure 2: Likelihood ratio curves for evidence of suggestive quantitative trait loci for loin weight without external fat, protein content of the empty body at 30 kg body weight and daily feed intake (DFI) 120–140 kg on SSCX. Positions in cM are based on the USDA reference map.

Mentions: A QTL significant at the 1% chromosome-wide level was identified for entire loin weight in the pseudoautosomal region of SSCX at 7 cM between SW949 and SW980 explaining 3.7% of the phenotypic variance (Figure 1). The significant additive effect at this QTL indicates that the grand-paternal Pietrain breed is associated with a 284 g higher loin weight. At a similar location in the pseudoautosomal region i.e. at 11 cM, a suggestive QTL was identified for loin weight without external fat explaining 2.5% of the phenotypic variance (Figure 2). The significant additive effect at this QTL indicates that the grand-paternal Pietrain breed is associated with a 185 g higher lean meat weight of the loin cut. At the telomeric end of the q arm of SSCX, at the same position as SW2588 (128.4 cM) a QTL significant at the 1% chromosome-wide level was identified for jowl weight accounting for 5.8% of the phenotypic variance (Figure 1). The significant dominance effect at this QTL indicates that heterozygous animals are associated with a 217 g higher jowl weight.


Genomic scan for quantitative trait loci of chemical and physical body composition and deposition on pig chromosome X including the pseudoautosomal region of males.

Duthie CA, Simm G, Pérez-Enciso M, Doeschl-Wilson A, Kalm E, Knap PW, Roehe R - Genet. Sel. Evol. (2009)

Likelihood ratio curves for evidence of suggestive quantitative trait loci for loin weight without external fat, protein content of the empty body at 30 kg body weight and daily feed intake (DFI) 120–140 kg on SSCX. Positions in cM are based on the USDA reference map.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2666071&req=5

Figure 2: Likelihood ratio curves for evidence of suggestive quantitative trait loci for loin weight without external fat, protein content of the empty body at 30 kg body weight and daily feed intake (DFI) 120–140 kg on SSCX. Positions in cM are based on the USDA reference map.
Mentions: A QTL significant at the 1% chromosome-wide level was identified for entire loin weight in the pseudoautosomal region of SSCX at 7 cM between SW949 and SW980 explaining 3.7% of the phenotypic variance (Figure 1). The significant additive effect at this QTL indicates that the grand-paternal Pietrain breed is associated with a 284 g higher loin weight. At a similar location in the pseudoautosomal region i.e. at 11 cM, a suggestive QTL was identified for loin weight without external fat explaining 2.5% of the phenotypic variance (Figure 2). The significant additive effect at this QTL indicates that the grand-paternal Pietrain breed is associated with a 185 g higher lean meat weight of the loin cut. At the telomeric end of the q arm of SSCX, at the same position as SW2588 (128.4 cM) a QTL significant at the 1% chromosome-wide level was identified for jowl weight accounting for 5.8% of the phenotypic variance (Figure 1). The significant dominance effect at this QTL indicates that heterozygous animals are associated with a 217 g higher jowl weight.

Bottom Line: A three-generation full-sib population of 386 animals was created by crossing Pietrain sires with a crossbred dam line.Several significant and suggestive QTL were detected on pig chromosome X: (1) in the pseudoautosomal region of SSCX, a QTL for entire loin weight, which showed paternal imprinting, (2) closely linked to marker SW2456, a suggestive QTL for feed intake at which Pietrain alleles were found to be associated with higher feed intake, which is unexpected for a breed known for its low feed intake capacity, (3) at the telomeric end of the q arm of SSCX, QTL for jowl weight and lipid accretion and (4) suggestive QTL for chemical body composition at 30 kg.These results indicate that SSCX is important for physical and chemical body composition and accretion as well as feed intake regulation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Animal Breeding and Development, Sustainable Livestock Systems Group, Scottish Agricultural College, West Mains Road, Edinburgh, UK. Carol-Anne.Duthie@sac.ac.uk

ABSTRACT
A QTL analysis of pig chromosome X (SSCX) was carried out using an approach that accurately takes into account the specific features of sex chromosomes i.e. their heterogeneity, the presence of a pseudoautosomal region and the dosage compensation phenomenon. A three-generation full-sib population of 386 animals was created by crossing Pietrain sires with a crossbred dam line. Phenotypic data on 72 traits were recorded for at least 292 and up to 315 F2 animals including chemical body composition measured on live animals at five target weights ranging from 30 to 140 kg, daily gain and feed intake measured throughout growth, and carcass characteristics obtained at slaughter weight (140 kg). Several significant and suggestive QTL were detected on pig chromosome X: (1) in the pseudoautosomal region of SSCX, a QTL for entire loin weight, which showed paternal imprinting, (2) closely linked to marker SW2456, a suggestive QTL for feed intake at which Pietrain alleles were found to be associated with higher feed intake, which is unexpected for a breed known for its low feed intake capacity, (3) at the telomeric end of the q arm of SSCX, QTL for jowl weight and lipid accretion and (4) suggestive QTL for chemical body composition at 30 kg. These results indicate that SSCX is important for physical and chemical body composition and accretion as well as feed intake regulation.

Show MeSH
Related in: MedlinePlus