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Model-based analysis of flow-mediated dilation and intima-media thickness.

Bartoli G, Menegaz G, Lisi M, Di Stolfo G, Dragoni S, Gori T - Int J Biomed Imaging (2009)

Bottom Line: The system allows real-time processing as well as a high level of interactivity with the user.This is obtained by a graphical user interface (GUI) enabling the cardiologist to supervise the whole process and to eventually reset the contour extraction at any point in time.Jointly with the user friendliness, low cost, and robustness, this makes the system suitable for both research and daily clinical use.

View Article: PubMed Central - PubMed

Affiliation: Department of Information Engineering, University of Siena, 53100 Siena, Italy.

ABSTRACT
We present an end-to-end system for the automatic measurement of flow-mediated dilation (FMD) and intima-media thickness (IMT) for the assessment of the arterial function. The video sequences are acquired from a B-mode echographic scanner. A spline model (deformable template) is fitted to the data to detect the artery boundaries and track them all along the video sequence. The a priori knowledge about the image features and its content is exploited. Preprocessing is performed to improve both the visual quality of video frames for visual inspection and the performance of the segmentation algorithm without affecting the accuracy of the measurements. The system allows real-time processing as well as a high level of interactivity with the user. This is obtained by a graphical user interface (GUI) enabling the cardiologist to supervise the whole process and to eventually reset the contour extraction at any point in time. The system was validated and the accuracy, reproducibility, and repeatability of the measurements were assessed with extensive in vivo experiments. Jointly with the user friendliness, low cost, and robustness, this makes the system suitable for both research and daily clinical use.

No MeSH data available.


Related in: MedlinePlus

FMD analysis. (a) Correlation between manual (goldstandard, horizontal axis) and automatic (vertical axis) analyses; (b) Bland and Altman plot: difference between softwareand manual measurements versus their average.
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fig5: FMD analysis. (a) Correlation between manual (goldstandard, horizontal axis) and automatic (vertical axis) analyses; (b) Bland and Altman plot: difference between softwareand manual measurements versus their average.

Mentions: In order toassess the accuracy, 100 frames wereanalyzed both manually and using the new software. The two sets of measurementsare highly correlated, as illustrated in Figure 5(a). The intraclasscoefficient was ICC = 0.97 (P < .0001). The range of variation was equal to RV = 76 (2–220) μm for arterieswith an average diameter of 2.35 mm. The Blandand Altman plot is shown in Figure 5(b).


Model-based analysis of flow-mediated dilation and intima-media thickness.

Bartoli G, Menegaz G, Lisi M, Di Stolfo G, Dragoni S, Gori T - Int J Biomed Imaging (2009)

FMD analysis. (a) Correlation between manual (goldstandard, horizontal axis) and automatic (vertical axis) analyses; (b) Bland and Altman plot: difference between softwareand manual measurements versus their average.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2665907&req=5

fig5: FMD analysis. (a) Correlation between manual (goldstandard, horizontal axis) and automatic (vertical axis) analyses; (b) Bland and Altman plot: difference between softwareand manual measurements versus their average.
Mentions: In order toassess the accuracy, 100 frames wereanalyzed both manually and using the new software. The two sets of measurementsare highly correlated, as illustrated in Figure 5(a). The intraclasscoefficient was ICC = 0.97 (P < .0001). The range of variation was equal to RV = 76 (2–220) μm for arterieswith an average diameter of 2.35 mm. The Blandand Altman plot is shown in Figure 5(b).

Bottom Line: The system allows real-time processing as well as a high level of interactivity with the user.This is obtained by a graphical user interface (GUI) enabling the cardiologist to supervise the whole process and to eventually reset the contour extraction at any point in time.Jointly with the user friendliness, low cost, and robustness, this makes the system suitable for both research and daily clinical use.

View Article: PubMed Central - PubMed

Affiliation: Department of Information Engineering, University of Siena, 53100 Siena, Italy.

ABSTRACT
We present an end-to-end system for the automatic measurement of flow-mediated dilation (FMD) and intima-media thickness (IMT) for the assessment of the arterial function. The video sequences are acquired from a B-mode echographic scanner. A spline model (deformable template) is fitted to the data to detect the artery boundaries and track them all along the video sequence. The a priori knowledge about the image features and its content is exploited. Preprocessing is performed to improve both the visual quality of video frames for visual inspection and the performance of the segmentation algorithm without affecting the accuracy of the measurements. The system allows real-time processing as well as a high level of interactivity with the user. This is obtained by a graphical user interface (GUI) enabling the cardiologist to supervise the whole process and to eventually reset the contour extraction at any point in time. The system was validated and the accuracy, reproducibility, and repeatability of the measurements were assessed with extensive in vivo experiments. Jointly with the user friendliness, low cost, and robustness, this makes the system suitable for both research and daily clinical use.

No MeSH data available.


Related in: MedlinePlus