The transcriptome of retinal Müller glial cells.
Bottom Line: Genes expressed exclusively by Müller glia were identified as novel markers.In addition, a novel BAC transgenic mouse that expresses Cre in Müller glia cells was generated.The molecular fingerprint of Müller glia provides a foundation for further studies of Müller glia development and function in normal and diseased states.
Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.Show MeSH
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Mentions: Expression of the paired-type homeobox, Pax6, was noted in four out of five of the single Müller glial cells (Fig. 5). Pax6 is a marker for progenitor cells and also for ganglion cells, amacrine cells, and horizontal cells in the mature retina. It has not been reported to be expressed in mature Müller glia. However, expression is consistent with the expression of other progenitor genes in Müller glia.
Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.