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REM sleep, prefrontal theta, and the consolidation of human emotional memory.

Nishida M, Pearsall J, Buckner RL, Walker MP - Cereb. Cortex (2008)

Bottom Line: Sleep also facilitates offline memory processing, resulting in superior recall the next day.Subjects that napped showed a consolidation benefit for emotional but not neutral memories.The No-Nap control group showed no evidence of a consolidation benefit for either memory type.

View Article: PubMed Central - PubMed

Affiliation: Sleep and Neuroimaging Laboratory Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94702-1650, USA.

ABSTRACT
Both emotion and sleep are independently known to modulate declarative memory. Memory can be facilitated by emotion, leading to enhanced consolidation across increasing time delays. Sleep also facilitates offline memory processing, resulting in superior recall the next day. Here we explore whether rapid eye movement (REM) sleep, and aspects of its unique neurophysiology, underlie these convergent influences on memory. Using a nap paradigm, we measured the consolidation of neutral and negative emotional memories, and the association with REM-sleep electrophysiology. Subjects that napped showed a consolidation benefit for emotional but not neutral memories. The No-Nap control group showed no evidence of a consolidation benefit for either memory type. Within the Nap group, the extent of emotional memory facilitation was significantly correlated with the amount of REM sleep and also with right-dominant prefrontal theta power during REM. Together, these data support the role of REM-sleep neurobiology in the consolidation of emotional human memories, findings that have direct translational implications for affective psychiatric and mood disorders.

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Related in: MedlinePlus

(A) Recognition memory score (d′) for neutral items studied 4 h or 15 min prior to the test session in the No-Nap and Nap groups. (B) The difference in recognition memory between the 4-h and 15-min study sessions [4 h score–15 min score] for the No-Nap and Nap group (i.e., the offline consolidation difference for items studied 4 h vs. 15 min prior to the recognition test). n.s., nonsignificant. Error bars represent standard error of the mean.
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fig3: (A) Recognition memory score (d′) for neutral items studied 4 h or 15 min prior to the test session in the No-Nap and Nap groups. (B) The difference in recognition memory between the 4-h and 15-min study sessions [4 h score–15 min score] for the No-Nap and Nap group (i.e., the offline consolidation difference for items studied 4 h vs. 15 min prior to the recognition test). n.s., nonsignificant. Error bars represent standard error of the mean.

Mentions: Note: Corresponding discrimination index (d′) for each category is displayed in Figures 2 and 3.


REM sleep, prefrontal theta, and the consolidation of human emotional memory.

Nishida M, Pearsall J, Buckner RL, Walker MP - Cereb. Cortex (2008)

(A) Recognition memory score (d′) for neutral items studied 4 h or 15 min prior to the test session in the No-Nap and Nap groups. (B) The difference in recognition memory between the 4-h and 15-min study sessions [4 h score–15 min score] for the No-Nap and Nap group (i.e., the offline consolidation difference for items studied 4 h vs. 15 min prior to the recognition test). n.s., nonsignificant. Error bars represent standard error of the mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2665156&req=5

fig3: (A) Recognition memory score (d′) for neutral items studied 4 h or 15 min prior to the test session in the No-Nap and Nap groups. (B) The difference in recognition memory between the 4-h and 15-min study sessions [4 h score–15 min score] for the No-Nap and Nap group (i.e., the offline consolidation difference for items studied 4 h vs. 15 min prior to the recognition test). n.s., nonsignificant. Error bars represent standard error of the mean.
Mentions: Note: Corresponding discrimination index (d′) for each category is displayed in Figures 2 and 3.

Bottom Line: Sleep also facilitates offline memory processing, resulting in superior recall the next day.Subjects that napped showed a consolidation benefit for emotional but not neutral memories.The No-Nap control group showed no evidence of a consolidation benefit for either memory type.

View Article: PubMed Central - PubMed

Affiliation: Sleep and Neuroimaging Laboratory Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94702-1650, USA.

ABSTRACT
Both emotion and sleep are independently known to modulate declarative memory. Memory can be facilitated by emotion, leading to enhanced consolidation across increasing time delays. Sleep also facilitates offline memory processing, resulting in superior recall the next day. Here we explore whether rapid eye movement (REM) sleep, and aspects of its unique neurophysiology, underlie these convergent influences on memory. Using a nap paradigm, we measured the consolidation of neutral and negative emotional memories, and the association with REM-sleep electrophysiology. Subjects that napped showed a consolidation benefit for emotional but not neutral memories. The No-Nap control group showed no evidence of a consolidation benefit for either memory type. Within the Nap group, the extent of emotional memory facilitation was significantly correlated with the amount of REM sleep and also with right-dominant prefrontal theta power during REM. Together, these data support the role of REM-sleep neurobiology in the consolidation of emotional human memories, findings that have direct translational implications for affective psychiatric and mood disorders.

Show MeSH
Related in: MedlinePlus