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Bradykinin or acetylcholine as vasodilators to test endothelial venous function in healthy subjects.

Rabelo ER, Rohde LE, Schaan BD, Rubira MC, Ruschel KB, Plentz RD, Consolim-Colombo FM, Irigoyen MC, Moreno Junior H - Clinics (Sao Paulo) (2008)

Bottom Line: The maximum endothelium-dependent venodilation was similar for both drugs (p = 0.13), as well as the mean responses for each dose of both drugs (r = 0.96).The maximum responses to acetylcholine and bradykinin also had good agreement.There were no differences between acetylcholine and bradykinin as venodilators in this endothelial venous function investigation.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. rabelo@portoweb.com.br

ABSTRACT

Introduction: The evaluation of endothelial function has been performed in the arterial bed, but recently evaluation within the venous system has also been explored. Endothelial function studies employ different drugs that act as endothelium-dependent vasodilatory response inductors.

Objectives: The aim of this study is to compare the endothelium-dependent venous vasodilator response mediated by either acetylcholine or bradykinin in healthy volunteers.

Methods and results: Changes in vein diameter after phenylephrine-induced venoconstriction were measured to compare venodilation induced by acetylcholine or bradykinin (linear variable differential transformer dorsal hand vein technique). We studied 23 healthy volunteers; 31% were male, and the subject had a mean age of 33 +/- 8 years and a mean body mass index of 23 +/- 2 kg/m(2). The maximum endothelium-dependent venodilation was similar for both drugs (p = 0.13), as well as the mean responses for each dose of both drugs (r = 0.96). The maximum responses to acetylcholine and bradykinin also had good agreement.

Conclusion: There were no differences between acetylcholine and bradykinin as venodilators in this endothelial venous function investigation.

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Percentage maximal response from baseline (maximal effect, %) after infusion of acetylcholine (ACH) and bradykinin (BK)
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f1-17-0139: Percentage maximal response from baseline (maximal effect, %) after infusion of acetylcholine (ACH) and bradykinin (BK)

Mentions: Acetylcholine, bradykinin, phenylephrine and sodium nitroprusside infusions were well tolerated. None of the pharmacological intervention procedures resulted in changes in the blood pressure or heart rate, indicating that the doses used had no systemic effect, as expected. The maximum endothelium-dependent venodilation responses obtained by administering acetylcholine or bradykinin were that acetylcholine elicited an endothelium-dependent venodilation of 88 ± 38%, while bradykinin causes a 105 ± 41% venodilation (p = 0.12), as compared to basal values (Figure 1).


Bradykinin or acetylcholine as vasodilators to test endothelial venous function in healthy subjects.

Rabelo ER, Rohde LE, Schaan BD, Rubira MC, Ruschel KB, Plentz RD, Consolim-Colombo FM, Irigoyen MC, Moreno Junior H - Clinics (Sao Paulo) (2008)

Percentage maximal response from baseline (maximal effect, %) after infusion of acetylcholine (ACH) and bradykinin (BK)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2664727&req=5

f1-17-0139: Percentage maximal response from baseline (maximal effect, %) after infusion of acetylcholine (ACH) and bradykinin (BK)
Mentions: Acetylcholine, bradykinin, phenylephrine and sodium nitroprusside infusions were well tolerated. None of the pharmacological intervention procedures resulted in changes in the blood pressure or heart rate, indicating that the doses used had no systemic effect, as expected. The maximum endothelium-dependent venodilation responses obtained by administering acetylcholine or bradykinin were that acetylcholine elicited an endothelium-dependent venodilation of 88 ± 38%, while bradykinin causes a 105 ± 41% venodilation (p = 0.12), as compared to basal values (Figure 1).

Bottom Line: The maximum endothelium-dependent venodilation was similar for both drugs (p = 0.13), as well as the mean responses for each dose of both drugs (r = 0.96).The maximum responses to acetylcholine and bradykinin also had good agreement.There were no differences between acetylcholine and bradykinin as venodilators in this endothelial venous function investigation.

View Article: PubMed Central - PubMed

Affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. rabelo@portoweb.com.br

ABSTRACT

Introduction: The evaluation of endothelial function has been performed in the arterial bed, but recently evaluation within the venous system has also been explored. Endothelial function studies employ different drugs that act as endothelium-dependent vasodilatory response inductors.

Objectives: The aim of this study is to compare the endothelium-dependent venous vasodilator response mediated by either acetylcholine or bradykinin in healthy volunteers.

Methods and results: Changes in vein diameter after phenylephrine-induced venoconstriction were measured to compare venodilation induced by acetylcholine or bradykinin (linear variable differential transformer dorsal hand vein technique). We studied 23 healthy volunteers; 31% were male, and the subject had a mean age of 33 +/- 8 years and a mean body mass index of 23 +/- 2 kg/m(2). The maximum endothelium-dependent venodilation was similar for both drugs (p = 0.13), as well as the mean responses for each dose of both drugs (r = 0.96). The maximum responses to acetylcholine and bradykinin also had good agreement.

Conclusion: There were no differences between acetylcholine and bradykinin as venodilators in this endothelial venous function investigation.

Show MeSH
Related in: MedlinePlus