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Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging.

Sharma P, Brown SC, Bengtsson N, Zhang Q, Walter GA, Grobmyer SR, Santra S, Jiang H, Scott EW, Moudgil BM - Chem Mater (2008)

Bottom Line: Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions.Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

View Article: PubMed Central - PubMed

Affiliation: Materials Science and Engineering and Particle Engineering Research Center, Molecular Genetics and Microbiology, Biomedical Engineering, Physiology and Functional Genomics, and Department of Surgery, University of Florida, P.O. Box 116135 Gainesville, Florida 32611, and NanoScience Technology Center, Chemistry and Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826.

ABSTRACT
Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions. Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

No MeSH data available.


(A) The PAT and (B) MRI (T1) contrast from the same phantom, using 1, 3, and 5 μL (particle concentration, 10 mg/mL) of Gd-doped GSS using sample in tissue-like phantom with background absorption coefficient μa = 0.007 mm−1 and scattering coefficient, μs′ = 0.5 mm−1, demonstrating the multimodal nature of the nanoparticles.
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fig5: (A) The PAT and (B) MRI (T1) contrast from the same phantom, using 1, 3, and 5 μL (particle concentration, 10 mg/mL) of Gd-doped GSS using sample in tissue-like phantom with background absorption coefficient μa = 0.007 mm−1 and scattering coefficient, μs′ = 0.5 mm−1, demonstrating the multimodal nature of the nanoparticles.

Mentions: To evaluate the bimodal character of the GSS nanoparticles, simultaneous MR and photoacoustic evaluation was carried out. To achieve this, the GSS particles were placed in tissue-like phantom. The phantom was imaged for PAT and MR in succession, and the results are shown in Figure 5. An increase in the MR and PAT signal intensity is observed with increasing particulate amounts.


Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging.

Sharma P, Brown SC, Bengtsson N, Zhang Q, Walter GA, Grobmyer SR, Santra S, Jiang H, Scott EW, Moudgil BM - Chem Mater (2008)

(A) The PAT and (B) MRI (T1) contrast from the same phantom, using 1, 3, and 5 μL (particle concentration, 10 mg/mL) of Gd-doped GSS using sample in tissue-like phantom with background absorption coefficient μa = 0.007 mm−1 and scattering coefficient, μs′ = 0.5 mm−1, demonstrating the multimodal nature of the nanoparticles.
© Copyright Policy - open-access - ccc-price
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2664628&req=5

fig5: (A) The PAT and (B) MRI (T1) contrast from the same phantom, using 1, 3, and 5 μL (particle concentration, 10 mg/mL) of Gd-doped GSS using sample in tissue-like phantom with background absorption coefficient μa = 0.007 mm−1 and scattering coefficient, μs′ = 0.5 mm−1, demonstrating the multimodal nature of the nanoparticles.
Mentions: To evaluate the bimodal character of the GSS nanoparticles, simultaneous MR and photoacoustic evaluation was carried out. To achieve this, the GSS particles were placed in tissue-like phantom. The phantom was imaged for PAT and MR in succession, and the results are shown in Figure 5. An increase in the MR and PAT signal intensity is observed with increasing particulate amounts.

Bottom Line: Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions.Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

View Article: PubMed Central - PubMed

Affiliation: Materials Science and Engineering and Particle Engineering Research Center, Molecular Genetics and Microbiology, Biomedical Engineering, Physiology and Functional Genomics, and Department of Surgery, University of Florida, P.O. Box 116135 Gainesville, Florida 32611, and NanoScience Technology Center, Chemistry and Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826.

ABSTRACT
Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions. Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

No MeSH data available.