Limits...
Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging.

Sharma P, Brown SC, Bengtsson N, Zhang Q, Walter GA, Grobmyer SR, Santra S, Jiang H, Scott EW, Moudgil BM - Chem Mater (2008)

Bottom Line: Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions.Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

View Article: PubMed Central - PubMed

Affiliation: Materials Science and Engineering and Particle Engineering Research Center, Molecular Genetics and Microbiology, Biomedical Engineering, Physiology and Functional Genomics, and Department of Surgery, University of Florida, P.O. Box 116135 Gainesville, Florida 32611, and NanoScience Technology Center, Chemistry and Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826.

ABSTRACT
Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions. Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

No MeSH data available.


(A) Line scan of Gd-doped GSS nanoparticle showing the spectral emission from the constituent elements. (B) EDS spectrum of the multimodal nanoparticles showing the presence of silicon (Si), oxygen (O), gold (Au), and gadolinium (Gd).
© Copyright Policy - open-access - ccc-price
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2664628&req=5

fig3: (A) Line scan of Gd-doped GSS nanoparticle showing the spectral emission from the constituent elements. (B) EDS spectrum of the multimodal nanoparticles showing the presence of silicon (Si), oxygen (O), gold (Au), and gadolinium (Gd).

Mentions: The elemental composition of the Gd-doped GSS nanoparticles particles was determined using EDS and ICP techniques. A representative line scan (Figure 3A) and composite EDS spectrum (Figure 3B) showed the spectral counts corresponding to Si, O, Au, Gd, and the overall spectrum for the nanoparticle, respectively. The elemental composition as determined by ICP gave average number of atoms of Au and Gd to be ∼426 200 and ∼34 000 per nanoparticle, respectively. Theoretical calculations showed that ∼72 times more number of gold atoms would be present in a single gold nanoparticle of similar dimension. To our knowledge, this is the first report of one-pot synthesis of Gd-doped GSS nanoparticulate contrast agents as well as the first example of a multimodal contrast agent for MRI and PAT. The evaluation of the MRI and PAT bifunctional properties of these nanoparticulates has been demonstrated using agar gel phantoms as described in the following sections.


Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging.

Sharma P, Brown SC, Bengtsson N, Zhang Q, Walter GA, Grobmyer SR, Santra S, Jiang H, Scott EW, Moudgil BM - Chem Mater (2008)

(A) Line scan of Gd-doped GSS nanoparticle showing the spectral emission from the constituent elements. (B) EDS spectrum of the multimodal nanoparticles showing the presence of silicon (Si), oxygen (O), gold (Au), and gadolinium (Gd).
© Copyright Policy - open-access - ccc-price
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2664628&req=5

fig3: (A) Line scan of Gd-doped GSS nanoparticle showing the spectral emission from the constituent elements. (B) EDS spectrum of the multimodal nanoparticles showing the presence of silicon (Si), oxygen (O), gold (Au), and gadolinium (Gd).
Mentions: The elemental composition of the Gd-doped GSS nanoparticles particles was determined using EDS and ICP techniques. A representative line scan (Figure 3A) and composite EDS spectrum (Figure 3B) showed the spectral counts corresponding to Si, O, Au, Gd, and the overall spectrum for the nanoparticle, respectively. The elemental composition as determined by ICP gave average number of atoms of Au and Gd to be ∼426 200 and ∼34 000 per nanoparticle, respectively. Theoretical calculations showed that ∼72 times more number of gold atoms would be present in a single gold nanoparticle of similar dimension. To our knowledge, this is the first report of one-pot synthesis of Gd-doped GSS nanoparticulate contrast agents as well as the first example of a multimodal contrast agent for MRI and PAT. The evaluation of the MRI and PAT bifunctional properties of these nanoparticulates has been demonstrated using agar gel phantoms as described in the following sections.

Bottom Line: Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions.Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

View Article: PubMed Central - PubMed

Affiliation: Materials Science and Engineering and Particle Engineering Research Center, Molecular Genetics and Microbiology, Biomedical Engineering, Physiology and Functional Genomics, and Department of Surgery, University of Florida, P.O. Box 116135 Gainesville, Florida 32611, and NanoScience Technology Center, Chemistry and Biomolecular Science Center, University of Central Florida, Orlando, Florida 32826.

ABSTRACT
Multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography have been prepared in a simple one-pot synthesis using nonionic microemulsions. Magnetic resonance contrast is provided through gadolinium incorporated in the silica matrix, whereas the photoacoustic signal originates from nonuniform, discontinuous gold nanodomains speckled across the silica surface.

No MeSH data available.