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Pretreatment tumor volume estimation based on total serum psa in patients with localized prostate cancer.

Kato RB, Srougi V, Salvadori FA, Ayres PP, Leite KM, Srougi M - Clinics (Sao Paulo) (2008)

Bottom Line: From 1997 to 2002, 735 patients with prostate cancer of stagesT1c-T2c without any previous treatment were submitted to radical prostatectomy.Pretreatment serum prostate specific antigen was correlated with tumor volume in each patient using a linear regression model.Total and percent tumor volume could be calculated, respectively, using the formulas Volume (cc) = 3.476 + 0.302 x PSA (ng/ml) and Volume (%) = 11.331 + 0.704 x prostate specific antigen (ng/ml).

View Article: PubMed Central - PubMed

Affiliation: Division of Urology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. kato_med91@yahoo.com.br

ABSTRACT

Objectives: To establish a formula that estimates tumor volume in localized prostate cancer based on serum prostate specific antigen levels. One of the main prognostic variables in localized prostate cancer is tumor volume, which can be precisely defined only after prostate extirpation. The present study defines a simple method that allows for estimation of tumor volume before treatment, which can help to establish a better therapeutic strategy for each patient.

Methods: From 1997 to 2002, 735 patients with prostate cancer of stagesT1c-T2c without any previous treatment were submitted to radical prostatectomy. Surgical specimens were evaluated by the same pathologist and the total tumor volume (in cc) and the relative tumor volume (as the percent of the total prostate volume) were determined using the grid morphometric method. Pretreatment serum prostate specific antigen was correlated with tumor volume in each patient using a linear regression model.

Results: There were positive correlations between the serum levels of prostate specific antigen and the total tumor volume in cc (p<0.001) and the relative tumor volume as a percentage (p<0.001). For each ng/ml unit increment of serum prostate specific antigen, there was a 0.302 cc increase in total tumor volume and a 0.7% increase in relative tumor volume. Total and percent tumor volume could be calculated, respectively, using the formulas Volume (cc) = 3.476 + 0.302 x PSA (ng/ml) and Volume (%) = 11.331 + 0.704 x prostate specific antigen (ng/ml).

Conclusions: Tumor volume in patients with prostate cancer can be determined before treatment based on the serum prostate specific antigen levels.

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Related in: MedlinePlus

Correlation between relative tumor volume (%) and serum PSA levels (Pearson’s correlation = 0.289 [IC 95% : 0.221 – 0.354], p<0.001)
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f2-09-cs-0161: Correlation between relative tumor volume (%) and serum PSA levels (Pearson’s correlation = 0.289 [IC 95% : 0.221 – 0.354], p<0.001)

Mentions: As shown in Figure 1, a statistically significant correlation was observed between the tumor volume in cc and serum PSA levels (p<0.001). Likewise, as shown in Figure 2, a positive correlation was demonstrated between the percentage of tumor volume and serum PSA levels (p<0.001). A statistical analysis of the data plotted in Figure 1 shows that, for each 1 ng/ml increment in serum PSA, the absolute tumor volume increases by 0.302 cc. The linear regression equation is:


Pretreatment tumor volume estimation based on total serum psa in patients with localized prostate cancer.

Kato RB, Srougi V, Salvadori FA, Ayres PP, Leite KM, Srougi M - Clinics (Sao Paulo) (2008)

Correlation between relative tumor volume (%) and serum PSA levels (Pearson’s correlation = 0.289 [IC 95% : 0.221 – 0.354], p<0.001)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2664275&req=5

f2-09-cs-0161: Correlation between relative tumor volume (%) and serum PSA levels (Pearson’s correlation = 0.289 [IC 95% : 0.221 – 0.354], p<0.001)
Mentions: As shown in Figure 1, a statistically significant correlation was observed between the tumor volume in cc and serum PSA levels (p<0.001). Likewise, as shown in Figure 2, a positive correlation was demonstrated between the percentage of tumor volume and serum PSA levels (p<0.001). A statistical analysis of the data plotted in Figure 1 shows that, for each 1 ng/ml increment in serum PSA, the absolute tumor volume increases by 0.302 cc. The linear regression equation is:

Bottom Line: From 1997 to 2002, 735 patients with prostate cancer of stagesT1c-T2c without any previous treatment were submitted to radical prostatectomy.Pretreatment serum prostate specific antigen was correlated with tumor volume in each patient using a linear regression model.Total and percent tumor volume could be calculated, respectively, using the formulas Volume (cc) = 3.476 + 0.302 x PSA (ng/ml) and Volume (%) = 11.331 + 0.704 x prostate specific antigen (ng/ml).

View Article: PubMed Central - PubMed

Affiliation: Division of Urology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. kato_med91@yahoo.com.br

ABSTRACT

Objectives: To establish a formula that estimates tumor volume in localized prostate cancer based on serum prostate specific antigen levels. One of the main prognostic variables in localized prostate cancer is tumor volume, which can be precisely defined only after prostate extirpation. The present study defines a simple method that allows for estimation of tumor volume before treatment, which can help to establish a better therapeutic strategy for each patient.

Methods: From 1997 to 2002, 735 patients with prostate cancer of stagesT1c-T2c without any previous treatment were submitted to radical prostatectomy. Surgical specimens were evaluated by the same pathologist and the total tumor volume (in cc) and the relative tumor volume (as the percent of the total prostate volume) were determined using the grid morphometric method. Pretreatment serum prostate specific antigen was correlated with tumor volume in each patient using a linear regression model.

Results: There were positive correlations between the serum levels of prostate specific antigen and the total tumor volume in cc (p<0.001) and the relative tumor volume as a percentage (p<0.001). For each ng/ml unit increment of serum prostate specific antigen, there was a 0.302 cc increase in total tumor volume and a 0.7% increase in relative tumor volume. Total and percent tumor volume could be calculated, respectively, using the formulas Volume (cc) = 3.476 + 0.302 x PSA (ng/ml) and Volume (%) = 11.331 + 0.704 x prostate specific antigen (ng/ml).

Conclusions: Tumor volume in patients with prostate cancer can be determined before treatment based on the serum prostate specific antigen levels.

Show MeSH
Related in: MedlinePlus