Limits...
Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis.

Carvalho MO, Barros Filho TE, Tebet MA - Clinics (Sao Paulo) (2008)

Bottom Line: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>0.05).Administration of methylprednisolone alone or with GM-1 was shown to be effective for recovery of locomotive function.Combined administration of these drugs resulted in better outcomes than administration of methylprednisolone alone.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopedics and Traumatology, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil. marciopennac@uol.com.br

ABSTRACT

Objectives: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs.

Methods: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day.

Results: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (p<0.05). The group that received MP together with GM-1 presented results that were better than those of the control group (p<0.05).

Conclusion: Administration of methylprednisolone alone or with GM-1 was shown to be effective for recovery of locomotive function. Combined administration of these drugs resulted in better outcomes than administration of methylprednisolone alone.

Show MeSH

Related in: MedlinePlus

Exposure of the dura mater following laminectomy
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2664232&req=5

f1-cln63_3p0375: Exposure of the dura mater following laminectomy

Mentions: For the anesthesia procedure, pentobarbital was administered via the intraperitoneal route at a dose of 65 mg/ kg. A skin incision of approximately 5 cm was made along the dorsal medial line. The paravertebral musculature was separated from the spinous processes to expose the vertebral column from T8 to T12. Then, with an appropriate punch, laminectomy was performed in the distal half of T9 and T10, without causing injury to the dural sac, thereby allowing enough space to accommodate the impactor head (Figure 1).


Effects of methylprednisolone and ganglioside GM-1 on a spinal lesion: a functional analysis.

Carvalho MO, Barros Filho TE, Tebet MA - Clinics (Sao Paulo) (2008)

Exposure of the dura mater following laminectomy
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2664232&req=5

f1-cln63_3p0375: Exposure of the dura mater following laminectomy
Mentions: For the anesthesia procedure, pentobarbital was administered via the intraperitoneal route at a dose of 65 mg/ kg. A skin incision of approximately 5 cm was made along the dorsal medial line. The paravertebral musculature was separated from the spinous processes to expose the vertebral column from T8 to T12. Then, with an appropriate punch, laminectomy was performed in the distal half of T9 and T10, without causing injury to the dural sac, thereby allowing enough space to accommodate the impactor head (Figure 1).

Bottom Line: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>0.05).Administration of methylprednisolone alone or with GM-1 was shown to be effective for recovery of locomotive function.Combined administration of these drugs resulted in better outcomes than administration of methylprednisolone alone.

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopedics and Traumatology, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil. marciopennac@uol.com.br

ABSTRACT

Objectives: The pharmacological effects of methylprednisolone (MP) and ganglioside GM-1 on spinal injuries have been thoroughly investigated, but only a few studies have evaluated the interaction between these two drugs.

Methods: Twenty-four Wistar rats were subjected to contusive injury of the spinal cord produced by the NYU system. These animals were divided into four groups: group I was injected with MP; group II was injected with GM-1; group III was injected with MP together with GM-1; and group control received physiological serum. The animals were evaluated with regard to their recovery of locomotive function by means of the BBB test on the second, seventh and fourteenth days after receiving the contusive injury to the spinal cord. They were sacrificed on the fourteenth day.

Results: This study demonstrated that the MP and GM-1 groups presented functional results that were better than those of the control group, although the enhanced recovery of group II (GM-1) relative to the control group was not statistically significant (p>0.05). The most notable recovery of locomotive function was observed in the group that received MP alone (p<0.05). The group that received MP together with GM-1 presented results that were better than those of the control group (p<0.05).

Conclusion: Administration of methylprednisolone alone or with GM-1 was shown to be effective for recovery of locomotive function. Combined administration of these drugs resulted in better outcomes than administration of methylprednisolone alone.

Show MeSH
Related in: MedlinePlus