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Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma.

Bispo Júnior RZ, Camargo OP, Oliveira CR, Filippi RZ, Baptista AM, Caiero MT - Clinics (Sao Paulo) (2008)

Bottom Line: Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis.Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003).The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival).

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopedics and Traumatology, HC, Medical School, São Paulo University, São Paulo, SP, Brazil. zosimo_jr@yahoo.com.br

ABSTRACT

Objective: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities.

Materials and methods: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria.

Results: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003).

Conclusions: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas.

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Related in: MedlinePlus

Curve depicting overall survival (years) for the 25 patients with liposarcoma of the extremities
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f3-cln63_2p0157: Curve depicting overall survival (years) for the 25 patients with liposarcoma of the extremities

Mentions: The overall survival curve for the 25 patients is shown in Figure 3. Age under 50 years (P = 0.036), male sex (P = 0.043), pleomorphic subtype (P = 0.001), and high histological grade (P = 0.003) were also considered adverse factors. Site, side of body, delay in seeking medical advice, specimen size, and type of treatment performed did not reach statistically significant levels. Also, the presence or absence of MDM2 protein expression did not influence the overall survival.


Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma.

Bispo Júnior RZ, Camargo OP, Oliveira CR, Filippi RZ, Baptista AM, Caiero MT - Clinics (Sao Paulo) (2008)

Curve depicting overall survival (years) for the 25 patients with liposarcoma of the extremities
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2664204&req=5

f3-cln63_2p0157: Curve depicting overall survival (years) for the 25 patients with liposarcoma of the extremities
Mentions: The overall survival curve for the 25 patients is shown in Figure 3. Age under 50 years (P = 0.036), male sex (P = 0.043), pleomorphic subtype (P = 0.001), and high histological grade (P = 0.003) were also considered adverse factors. Site, side of body, delay in seeking medical advice, specimen size, and type of treatment performed did not reach statistically significant levels. Also, the presence or absence of MDM2 protein expression did not influence the overall survival.

Bottom Line: Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis.Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003).The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival).

View Article: PubMed Central - PubMed

Affiliation: Institute of Orthopedics and Traumatology, HC, Medical School, São Paulo University, São Paulo, SP, Brazil. zosimo_jr@yahoo.com.br

ABSTRACT

Objective: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities.

Materials and methods: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria.

Results: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003).

Conclusions: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas.

Show MeSH
Related in: MedlinePlus