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High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease.

da Luz PL, Favarato D, Faria-Neto JR, Lemos P, Chagas AC - Clinics (Sao Paulo) (2008)

Bottom Line: High-risk patients (n=374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index.However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p=0.33)] or LDL-c [1.47 (0.96-2.25; p=0.0842)].Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent.

View Article: PubMed Central - PubMed

Affiliation: Insituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. daluzp@incor.usp.br

ABSTRACT

Unlabelled: An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic lipid profile and a risk for the development of coronary disease.

Objective: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease.

Methods: High-risk patients (n=374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index.

Results: The subjects consisted of 220 males and 154 females, age 57.2+/-11.1 years, with total cholesterol of 210+/-50.3 mg/dL, triglycerides of 173.8+/-169.8 mg/dL, HDL-cholesterol (HDL-c) of 40.1+/-12.8 mg/dL, LDL-cholesterol (LDL-c) of 137.3+/-46.2 mg/dL, TG/HDL-c of 5.1+/-5.3, and a Friesinger index of 6.6+/-4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal) was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p=0.0018); HDL-c, odds ratio of 2.21 (1.42-3.43; p=0.0005); and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p=0.0018). However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p=0.33)] or LDL-c [1.47 (0.96-2.25; p=0.0842)]. The chi-square for linear trends for Friesinger >4 and lipid quartiles was statistically significant for triglycerides (p=0.0017), HDL-c (p=0.0001), and TG/HDL-c (p=0.0018), but not for total cholesterol (p=0.393) or LDL-c (p=0.0568). The multivariate analysis by logistic regression OR gave 1.3+/-0.79 (p= .0001) for TG/HDL-c, 0.779+/-0.074 (p= .0001) for HDL-c, and 1.234+/-0.097 (p=0.03) for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease.

Conclusions: Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent.

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Boxplot distribution of Friesinger index by quartiles of total cholesterol, triglycerides, HDL-cholesterol, and TG/HDL-cholesterol
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f2-cln63_4p0427: Boxplot distribution of Friesinger index by quartiles of total cholesterol, triglycerides, HDL-cholesterol, and TG/HDL-cholesterol

Mentions: The odds ratios for the extent of coronary disease between the fourth and first quartiles were as follows: total cholesterol, 1.08, 95%CI (0.57–2.03), p = 0.87; LDL-c, 1.62, 95%CI (0.86–3.06), p = 0.15; triglycerides, 1.7, 95%CI (0.94–3.08), p = 0.986; HDL-c, 0.25, 95%CI (0.13–0.46), p = 0.0001; and TG/HDL-c, 3.31, 95%CI (1.78–6.14), p = 0.0002 (Figure 1). This analysis showed that only HDL-c and TG/HDL-c show statistically significant frequency differences between the fourth and first quartiles, and that the difference was larger for TG/HDL-c. The non-parametric ANOVA (Kruskal-Wallis) demonstrated a significant association between extensive coronary disease and the lipid variable quartiles. However, only HDL-c and TG/HDL-c--primarily the latter--showed statistically significant differences in median Friesinger index between abnormal values and normal ones. Total cholesterol and LDL-c showed a similar distribution and Figure 2 therefore presents only the Friesinger distribution for the quartiles of total cholesterol, triglycerides, HDL-c, and TG/HDL-c.


High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease.

da Luz PL, Favarato D, Faria-Neto JR, Lemos P, Chagas AC - Clinics (Sao Paulo) (2008)

Boxplot distribution of Friesinger index by quartiles of total cholesterol, triglycerides, HDL-cholesterol, and TG/HDL-cholesterol
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2664115&req=5

f2-cln63_4p0427: Boxplot distribution of Friesinger index by quartiles of total cholesterol, triglycerides, HDL-cholesterol, and TG/HDL-cholesterol
Mentions: The odds ratios for the extent of coronary disease between the fourth and first quartiles were as follows: total cholesterol, 1.08, 95%CI (0.57–2.03), p = 0.87; LDL-c, 1.62, 95%CI (0.86–3.06), p = 0.15; triglycerides, 1.7, 95%CI (0.94–3.08), p = 0.986; HDL-c, 0.25, 95%CI (0.13–0.46), p = 0.0001; and TG/HDL-c, 3.31, 95%CI (1.78–6.14), p = 0.0002 (Figure 1). This analysis showed that only HDL-c and TG/HDL-c show statistically significant frequency differences between the fourth and first quartiles, and that the difference was larger for TG/HDL-c. The non-parametric ANOVA (Kruskal-Wallis) demonstrated a significant association between extensive coronary disease and the lipid variable quartiles. However, only HDL-c and TG/HDL-c--primarily the latter--showed statistically significant differences in median Friesinger index between abnormal values and normal ones. Total cholesterol and LDL-c showed a similar distribution and Figure 2 therefore presents only the Friesinger distribution for the quartiles of total cholesterol, triglycerides, HDL-c, and TG/HDL-c.

Bottom Line: High-risk patients (n=374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index.However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p=0.33)] or LDL-c [1.47 (0.96-2.25; p=0.0842)].Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent.

View Article: PubMed Central - PubMed

Affiliation: Insituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. daluzp@incor.usp.br

ABSTRACT

Unlabelled: An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic lipid profile and a risk for the development of coronary disease.

Objective: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease.

Methods: High-risk patients (n=374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index.

Results: The subjects consisted of 220 males and 154 females, age 57.2+/-11.1 years, with total cholesterol of 210+/-50.3 mg/dL, triglycerides of 173.8+/-169.8 mg/dL, HDL-cholesterol (HDL-c) of 40.1+/-12.8 mg/dL, LDL-cholesterol (LDL-c) of 137.3+/-46.2 mg/dL, TG/HDL-c of 5.1+/-5.3, and a Friesinger index of 6.6+/-4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal) was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p=0.0018); HDL-c, odds ratio of 2.21 (1.42-3.43; p=0.0005); and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p=0.0018). However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p=0.33)] or LDL-c [1.47 (0.96-2.25; p=0.0842)]. The chi-square for linear trends for Friesinger >4 and lipid quartiles was statistically significant for triglycerides (p=0.0017), HDL-c (p=0.0001), and TG/HDL-c (p=0.0018), but not for total cholesterol (p=0.393) or LDL-c (p=0.0568). The multivariate analysis by logistic regression OR gave 1.3+/-0.79 (p= .0001) for TG/HDL-c, 0.779+/-0.074 (p= .0001) for HDL-c, and 1.234+/-0.097 (p=0.03) for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease.

Conclusions: Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent.

Show MeSH
Related in: MedlinePlus