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Potential mechanisms of muscle mitochondrial dysfunction in aging and obesity and cellular consequences.

Chanséaume E, Morio B - Int J Mol Sci (2009)

Bottom Line: Mitochondria play a key role in the energy metabolism in skeletal muscle.According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal muscle still remain to be elucidated.The present review focuses on recent data investigating these issues in the area of metabolic disorders and describes the potential causes, mechanisms and consequences of mitochondrial dysfunction in the skeletal muscle.

View Article: PubMed Central - PubMed

Affiliation: INRA, UMR Nutrition Humaine, Saint Genès Champanelle, France. emilie@nutrifizz.fr

ABSTRACT
Mitochondria play a key role in the energy metabolism in skeletal muscle. A new concept has emerged suggesting that impaired mitochondrial oxidative capacity in skeletal muscle may be the underlying defect that causes insulin resistance. According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal muscle still remain to be elucidated. The present review focuses on recent data investigating these issues in the area of metabolic disorders and describes the potential causes, mechanisms and consequences of mitochondrial dysfunction in the skeletal muscle.

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Related in: MedlinePlus

Summary of potential causes and cellular consequences of impaired mitochondrial oxidative and phosphorylation (OXPHOS) activity in skeletal muscle.Physiological factors associated to aging, hormonal changes, lifestyle behavior and diet, may impair muscle mitochondrial biogenesis and OXPHOS activity during lifespan. These alterations, named “acquired defects”, in association with “inherited defects” due to genetic or epigenetic processes, may favor the apparition of metabolic disorders which then hasten a vicious circle that can ultimately lead to pathological states.
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f2-ijms-10-00306: Summary of potential causes and cellular consequences of impaired mitochondrial oxidative and phosphorylation (OXPHOS) activity in skeletal muscle.Physiological factors associated to aging, hormonal changes, lifestyle behavior and diet, may impair muscle mitochondrial biogenesis and OXPHOS activity during lifespan. These alterations, named “acquired defects”, in association with “inherited defects” due to genetic or epigenetic processes, may favor the apparition of metabolic disorders which then hasten a vicious circle that can ultimately lead to pathological states.

Mentions: According to current knowledge, the underlying molecular mechanisms of muscle mitochondrial dysfunction in metabolic disorders are far from being elucidated. One or a combination of mechanisms involving genetics, disturbances in glucose and lipid homeostasis, oxidative stress and also a state of chronic low-grade inflammation, might be involved in the process leading to these defects. Figure 2 illustrates potential causes and cellular consequences of impaired mitochondrial oxidative capacity in skeletal muscle. Nowadays, understanding the molecular and biochemical defects responsible for muscle mitochondrial dysfunction is of importance to specify the role of mitochondrial dysfunction in the aetiology of metabolic disorders and to define preventive and therapeutic targets for the treatment of these pathologies.


Potential mechanisms of muscle mitochondrial dysfunction in aging and obesity and cellular consequences.

Chanséaume E, Morio B - Int J Mol Sci (2009)

Summary of potential causes and cellular consequences of impaired mitochondrial oxidative and phosphorylation (OXPHOS) activity in skeletal muscle.Physiological factors associated to aging, hormonal changes, lifestyle behavior and diet, may impair muscle mitochondrial biogenesis and OXPHOS activity during lifespan. These alterations, named “acquired defects”, in association with “inherited defects” due to genetic or epigenetic processes, may favor the apparition of metabolic disorders which then hasten a vicious circle that can ultimately lead to pathological states.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2662471&req=5

f2-ijms-10-00306: Summary of potential causes and cellular consequences of impaired mitochondrial oxidative and phosphorylation (OXPHOS) activity in skeletal muscle.Physiological factors associated to aging, hormonal changes, lifestyle behavior and diet, may impair muscle mitochondrial biogenesis and OXPHOS activity during lifespan. These alterations, named “acquired defects”, in association with “inherited defects” due to genetic or epigenetic processes, may favor the apparition of metabolic disorders which then hasten a vicious circle that can ultimately lead to pathological states.
Mentions: According to current knowledge, the underlying molecular mechanisms of muscle mitochondrial dysfunction in metabolic disorders are far from being elucidated. One or a combination of mechanisms involving genetics, disturbances in glucose and lipid homeostasis, oxidative stress and also a state of chronic low-grade inflammation, might be involved in the process leading to these defects. Figure 2 illustrates potential causes and cellular consequences of impaired mitochondrial oxidative capacity in skeletal muscle. Nowadays, understanding the molecular and biochemical defects responsible for muscle mitochondrial dysfunction is of importance to specify the role of mitochondrial dysfunction in the aetiology of metabolic disorders and to define preventive and therapeutic targets for the treatment of these pathologies.

Bottom Line: Mitochondria play a key role in the energy metabolism in skeletal muscle.According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal muscle still remain to be elucidated.The present review focuses on recent data investigating these issues in the area of metabolic disorders and describes the potential causes, mechanisms and consequences of mitochondrial dysfunction in the skeletal muscle.

View Article: PubMed Central - PubMed

Affiliation: INRA, UMR Nutrition Humaine, Saint Genès Champanelle, France. emilie@nutrifizz.fr

ABSTRACT
Mitochondria play a key role in the energy metabolism in skeletal muscle. A new concept has emerged suggesting that impaired mitochondrial oxidative capacity in skeletal muscle may be the underlying defect that causes insulin resistance. According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal muscle still remain to be elucidated. The present review focuses on recent data investigating these issues in the area of metabolic disorders and describes the potential causes, mechanisms and consequences of mitochondrial dysfunction in the skeletal muscle.

Show MeSH
Related in: MedlinePlus