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Molecular neuropathology of gliomas.

Riemenschneider MJ, Reifenberger G - Int J Mol Sci (2009)

Bottom Line: Gliomas are the most common primary human brain tumors.They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system.In fact, first steps have been undertaken in supplementing classical histopathological diagnosis by the use of molecular tests, such as MGMT promoter hypermethylation in glioblastomas or detection of losses of chromosome arms 1p and 19q in oligodendroglial tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropathology, Heinrich-Heine-University, Duesseldorf, Germany. m.j.riemenschneider@gmx.de

ABSTRACT
Gliomas are the most common primary human brain tumors. They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system. Over the past 20 years the cytogenetic and molecular genetic alterations associated with glioma formation and progression have been intensely studied and genetic profiles as additional aids to the definition of brain tumors have been incorporated in the WHO classification. In fact, first steps have been undertaken in supplementing classical histopathological diagnosis by the use of molecular tests, such as MGMT promoter hypermethylation in glioblastomas or detection of losses of chromosome arms 1p and 19q in oligodendroglial tumors. The tremendous progress that has been made in the use of array-based profiling techniques will likely contribute to a further molecular refinement of glioma classification and lead to the identification of glioma core pathways that can be specifically targeted by more individualized glioma therapies.

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Schematic representation of the molecular pathogenesis of pilocytic astrocytomas.
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f2-ijms-10-00184: Schematic representation of the molecular pathogenesis of pilocytic astrocytomas.

Mentions: In pilocytic astrocytomas molecular and cytogenetic investigations have identified far less chromosomal and genetic alterations than in the diffusely infiltrating astrocytomas described above. Chromosomal comparative genomic hybridization (CGH) studies in 48 pilocytic astrocytomas revealed chromosomal imbalances only in a small subgroup of seven neoplasms [45] with gain of 9q34.1-qter constituting the most common abnormality. Recurrent trisomies of chromosomes 5 and chromosome 7 have been reported in another study employing array-CGH on 53 pilocytic astrocytomas [46] (Figure 2).


Molecular neuropathology of gliomas.

Riemenschneider MJ, Reifenberger G - Int J Mol Sci (2009)

Schematic representation of the molecular pathogenesis of pilocytic astrocytomas.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2662467&req=5

f2-ijms-10-00184: Schematic representation of the molecular pathogenesis of pilocytic astrocytomas.
Mentions: In pilocytic astrocytomas molecular and cytogenetic investigations have identified far less chromosomal and genetic alterations than in the diffusely infiltrating astrocytomas described above. Chromosomal comparative genomic hybridization (CGH) studies in 48 pilocytic astrocytomas revealed chromosomal imbalances only in a small subgroup of seven neoplasms [45] with gain of 9q34.1-qter constituting the most common abnormality. Recurrent trisomies of chromosomes 5 and chromosome 7 have been reported in another study employing array-CGH on 53 pilocytic astrocytomas [46] (Figure 2).

Bottom Line: Gliomas are the most common primary human brain tumors.They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system.In fact, first steps have been undertaken in supplementing classical histopathological diagnosis by the use of molecular tests, such as MGMT promoter hypermethylation in glioblastomas or detection of losses of chromosome arms 1p and 19q in oligodendroglial tumors.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropathology, Heinrich-Heine-University, Duesseldorf, Germany. m.j.riemenschneider@gmx.de

ABSTRACT
Gliomas are the most common primary human brain tumors. They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system. Over the past 20 years the cytogenetic and molecular genetic alterations associated with glioma formation and progression have been intensely studied and genetic profiles as additional aids to the definition of brain tumors have been incorporated in the WHO classification. In fact, first steps have been undertaken in supplementing classical histopathological diagnosis by the use of molecular tests, such as MGMT promoter hypermethylation in glioblastomas or detection of losses of chromosome arms 1p and 19q in oligodendroglial tumors. The tremendous progress that has been made in the use of array-based profiling techniques will likely contribute to a further molecular refinement of glioma classification and lead to the identification of glioma core pathways that can be specifically targeted by more individualized glioma therapies.

Show MeSH
Related in: MedlinePlus