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Age and gender specific normal values of left ventricular mass, volume and function for gradient echo magnetic resonance imaging: a cross sectional study.

Cain PA, Ahl R, Hedstrom E, Ugander M, Allansdotter-Johnsson A, Friberg P, Arheden H - BMC Med Imaging (2009)

Bottom Line: SV and EF decreased with age.EF showed a rapid decline in adolescence compared to changes throughout adulthood.These findings demonstrate the need for age and gender specific normal ranges for clinical use.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Clinical Physiology, Lund University Hospital, SE-22185, Lund, Sweden. peteracain@gmail.com

ABSTRACT

Background: Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. The aims of the study were to determine age and gender specific normal reference values and to explore the normal physiological variation of these parameters from adolescence to late adulthood, in a cross sectional study.

Methods: Gradient echo CMR was performed at 1.5 T in 96 healthy volunteers (11-81 years, 50 male). Gender-specific analysis of parameters was undertaken in both absolute values and adjusted for body surface area (BSA).

Results: Age and gender specific normal ranges for LV volumes, mass and function are presented from the second through the eighth decade of life. LVM, ESV and EDV rose during adolescence and declined in adulthood. SV and EF decreased with age. Compared to adult females, adult males had higher BSA-adjusted values of EDV (p = 0.006) and ESV (p < 0.001), similar SV (p = 0.51) and lower EF (p = 0.014). No gender differences were seen in the youngest, 11-15 year, age range.

Conclusion: LV volumes, mass and function vary over a broad age range in healthy individuals. LV volumes and mass both rise in adolescence and decline with age. EF showed a rapid decline in adolescence compared to changes throughout adulthood. These findings demonstrate the need for age and gender specific normal ranges for clinical use.

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Related in: MedlinePlus

The normal age variation in left ventricular parameters in males (left) and females (right). Solid lines represent rational polynomial curve fit and dashed lines the 95% prediction intervals of this fit. Reference values are listed in Table 2. LVM = left ventricular mass, BSA = body surface area, EDV = end-diastolic volume.
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Figure 2: The normal age variation in left ventricular parameters in males (left) and females (right). Solid lines represent rational polynomial curve fit and dashed lines the 95% prediction intervals of this fit. Reference values are listed in Table 2. LVM = left ventricular mass, BSA = body surface area, EDV = end-diastolic volume.

Mentions: Information on the age dependence of LV mass and wall stress in the majority of this population have been published and discussed previously [14]. The current study, however, provides tabular values in order to ease the use of this information as reference values. Figure 2 and Figure 3 describe the changes in left ventricular mass with age.


Age and gender specific normal values of left ventricular mass, volume and function for gradient echo magnetic resonance imaging: a cross sectional study.

Cain PA, Ahl R, Hedstrom E, Ugander M, Allansdotter-Johnsson A, Friberg P, Arheden H - BMC Med Imaging (2009)

The normal age variation in left ventricular parameters in males (left) and females (right). Solid lines represent rational polynomial curve fit and dashed lines the 95% prediction intervals of this fit. Reference values are listed in Table 2. LVM = left ventricular mass, BSA = body surface area, EDV = end-diastolic volume.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2657902&req=5

Figure 2: The normal age variation in left ventricular parameters in males (left) and females (right). Solid lines represent rational polynomial curve fit and dashed lines the 95% prediction intervals of this fit. Reference values are listed in Table 2. LVM = left ventricular mass, BSA = body surface area, EDV = end-diastolic volume.
Mentions: Information on the age dependence of LV mass and wall stress in the majority of this population have been published and discussed previously [14]. The current study, however, provides tabular values in order to ease the use of this information as reference values. Figure 2 and Figure 3 describe the changes in left ventricular mass with age.

Bottom Line: SV and EF decreased with age.EF showed a rapid decline in adolescence compared to changes throughout adulthood.These findings demonstrate the need for age and gender specific normal ranges for clinical use.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Clinical Physiology, Lund University Hospital, SE-22185, Lund, Sweden. peteracain@gmail.com

ABSTRACT

Background: Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. The aims of the study were to determine age and gender specific normal reference values and to explore the normal physiological variation of these parameters from adolescence to late adulthood, in a cross sectional study.

Methods: Gradient echo CMR was performed at 1.5 T in 96 healthy volunteers (11-81 years, 50 male). Gender-specific analysis of parameters was undertaken in both absolute values and adjusted for body surface area (BSA).

Results: Age and gender specific normal ranges for LV volumes, mass and function are presented from the second through the eighth decade of life. LVM, ESV and EDV rose during adolescence and declined in adulthood. SV and EF decreased with age. Compared to adult females, adult males had higher BSA-adjusted values of EDV (p = 0.006) and ESV (p < 0.001), similar SV (p = 0.51) and lower EF (p = 0.014). No gender differences were seen in the youngest, 11-15 year, age range.

Conclusion: LV volumes, mass and function vary over a broad age range in healthy individuals. LV volumes and mass both rise in adolescence and decline with age. EF showed a rapid decline in adolescence compared to changes throughout adulthood. These findings demonstrate the need for age and gender specific normal ranges for clinical use.

Show MeSH
Related in: MedlinePlus