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Prospective surveillance of invasive group a streptococcal disease, Fiji, 2005-2007.

Steer AC, Jenney A, Kado J, Good MF, Batzloff M, Waqatakirewa L, Mullholland EK, Carapetis JR - Emerging Infect. Dis. (2009)

Bottom Line: Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5).Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type.Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention.

View Article: PubMed Central - PubMed

Affiliation: University of Melbourne, Melbourne, Victoria, Australia.

ABSTRACT
We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type. Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention.

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Related in: MedlinePlus

Invasive group A streptococcal disease in the Central Division of Fiji, December 5, 2005–November 5, 2007
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Figure 1: Invasive group A streptococcal disease in the Central Division of Fiji, December 5, 2005–November 5, 2007

Mentions: Sixty-four cases of invasive GAS disease occurred during the 23 months of surveillance. Sixty-two cases met the criteria for a definite case, and 2 cases met the criteria for a probable case. The average annualized all-ages incidence of invasive GAS disease (both definite and probable) in the Central Division was 9.9 cases/100,000 population/year (95% CI 7.6–2.6). There were an equal number of male and female case-patients. The median age of patients with invasive GAS disease was 51.6 years (interquartile range [IQR] 27.6–66.4 years). The youngest patient was aged 1 month, and 7 patients were <1 year of age, representing an incidence of 44.9/100,000 population (95% CI 18.1–92.5) in this age group (Figure). The peak incidence occurred in patients >65 years (incidence 80.6/100,000, 95% CI 46.1–130.8). Fifty-three cases occurred in indigenous Fijians (incidence 13.1/100,000, 95% CI 9.8–17.1), 5 cases in Indo-Fijians (incidence 2.5/100,000, 95% CI 0.8–5.9), and 6 cases in persons of other races (incidence 12.8/100,000, 95% CI 4.7–27.8). Of the 6 cases in persons of other races, 4 patients were Rotuman (incidence 47.4/100,000, 95% CI 12.9–121.4). When adjusted for the population of the Central Division, the incidence rate ratio for invasive GAS disease in indigenous Fijians versus other races was 2.9 (95% CI 1.5–6.1).


Prospective surveillance of invasive group a streptococcal disease, Fiji, 2005-2007.

Steer AC, Jenney A, Kado J, Good MF, Batzloff M, Waqatakirewa L, Mullholland EK, Carapetis JR - Emerging Infect. Dis. (2009)

Invasive group A streptococcal disease in the Central Division of Fiji, December 5, 2005–November 5, 2007
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2657613&req=5

Figure 1: Invasive group A streptococcal disease in the Central Division of Fiji, December 5, 2005–November 5, 2007
Mentions: Sixty-four cases of invasive GAS disease occurred during the 23 months of surveillance. Sixty-two cases met the criteria for a definite case, and 2 cases met the criteria for a probable case. The average annualized all-ages incidence of invasive GAS disease (both definite and probable) in the Central Division was 9.9 cases/100,000 population/year (95% CI 7.6–2.6). There were an equal number of male and female case-patients. The median age of patients with invasive GAS disease was 51.6 years (interquartile range [IQR] 27.6–66.4 years). The youngest patient was aged 1 month, and 7 patients were <1 year of age, representing an incidence of 44.9/100,000 population (95% CI 18.1–92.5) in this age group (Figure). The peak incidence occurred in patients >65 years (incidence 80.6/100,000, 95% CI 46.1–130.8). Fifty-three cases occurred in indigenous Fijians (incidence 13.1/100,000, 95% CI 9.8–17.1), 5 cases in Indo-Fijians (incidence 2.5/100,000, 95% CI 0.8–5.9), and 6 cases in persons of other races (incidence 12.8/100,000, 95% CI 4.7–27.8). Of the 6 cases in persons of other races, 4 patients were Rotuman (incidence 47.4/100,000, 95% CI 12.9–121.4). When adjusted for the population of the Central Division, the incidence rate ratio for invasive GAS disease in indigenous Fijians versus other races was 2.9 (95% CI 1.5–6.1).

Bottom Line: Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5).Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type.Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention.

View Article: PubMed Central - PubMed

Affiliation: University of Melbourne, Melbourne, Victoria, Australia.

ABSTRACT
We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type. Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention.

Show MeSH
Related in: MedlinePlus