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A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron) injection to treat fractures.

Kim SJ, Shin YW, Yang KH, Kim SB, Yoo MJ, Han SK, Im SA, Won YD, Sung YB, Jeon TS, Chang CH, Jang JD, Lee SB, Kim HC, Lee SY - BMC Musculoskelet Disord (2009)

Bottom Line: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Orthopedic Surgery, Catholic University College of Medicine, Seoul, Korea. peter@catholic.ac.kr

ABSTRACT

Background: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.

Methods: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.

Results: The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.

Conclusion: Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.

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Related in: MedlinePlus

The callus formation scores according to the patient ages of the osteoblast injection group.
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Figure 6: The callus formation scores according to the patient ages of the osteoblast injection group.

Mentions: There was no statistical difference in the osteoblast injection response between the younger and older age groups. Also, when we compared the 20–29 year old group with the other groups, there was no statistical difference (p = 0.71) (Fig. 6).


A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron) injection to treat fractures.

Kim SJ, Shin YW, Yang KH, Kim SB, Yoo MJ, Han SK, Im SA, Won YD, Sung YB, Jeon TS, Chang CH, Jang JD, Lee SB, Kim HC, Lee SY - BMC Musculoskelet Disord (2009)

The callus formation scores according to the patient ages of the osteoblast injection group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2656455&req=5

Figure 6: The callus formation scores according to the patient ages of the osteoblast injection group.
Mentions: There was no statistical difference in the osteoblast injection response between the younger and older age groups. Also, when we compared the 20–29 year old group with the other groups, there was no statistical difference (p = 0.71) (Fig. 6).

Bottom Line: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Orthopedic Surgery, Catholic University College of Medicine, Seoul, Korea. peter@catholic.ac.kr

ABSTRACT

Background: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.

Methods: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.

Results: The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.

Conclusion: Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.

Show MeSH
Related in: MedlinePlus