Limits...
Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and alpha-tocopherol presents in the extract of leaves of Cissus sicyoides L. (Vitaceae).

de Almeida ER, Rafael KR, Couto GB, Ishigami AB - J. Biomed. Biotechnol. (2009)

Bottom Line: The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried.The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions.These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

View Article: PubMed Central - PubMed

Affiliation: Evaluation Laboratory of Psychobioactive and Toxicology, Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. edvaldo.ra@gmail.com

ABSTRACT
The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

Show MeSH

Related in: MedlinePlus

Effect of diazepam and the extract of CS on the values of time spent in the closed arms, during 5 minutes. All doses used in this test had a time ofpermanence in the closed arm very significant in relation to the vehicle, andsimilar to diazepam *[F (1.13) = 5.5; P < .01]. 10animals were used in each group.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2655362&req=5

fig9: Effect of diazepam and the extract of CS on the values of time spent in the closed arms, during 5 minutes. All doses used in this test had a time ofpermanence in the closed arm very significant in relation to the vehicle, andsimilar to diazepam *[F (1.13) = 5.5; P < .01]. 10animals were used in each group.

Mentions: CS in all the doses (300, 600, and1000 mg/kg, IP) produced anxiolytic-like effects as determined by theincrease in the percentage of open arm entries *[F (1.14) = 5.6; P < .01]. Conversely, the number of entries and the time spent in the closed arms were reducedby CS treatment [F (1.13) = 5.5; P < .01] (Figures 8 and 9).


Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and alpha-tocopherol presents in the extract of leaves of Cissus sicyoides L. (Vitaceae).

de Almeida ER, Rafael KR, Couto GB, Ishigami AB - J. Biomed. Biotechnol. (2009)

Effect of diazepam and the extract of CS on the values of time spent in the closed arms, during 5 minutes. All doses used in this test had a time ofpermanence in the closed arm very significant in relation to the vehicle, andsimilar to diazepam *[F (1.13) = 5.5; P < .01]. 10animals were used in each group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2655362&req=5

fig9: Effect of diazepam and the extract of CS on the values of time spent in the closed arms, during 5 minutes. All doses used in this test had a time ofpermanence in the closed arm very significant in relation to the vehicle, andsimilar to diazepam *[F (1.13) = 5.5; P < .01]. 10animals were used in each group.
Mentions: CS in all the doses (300, 600, and1000 mg/kg, IP) produced anxiolytic-like effects as determined by theincrease in the percentage of open arm entries *[F (1.14) = 5.6; P < .01]. Conversely, the number of entries and the time spent in the closed arms were reducedby CS treatment [F (1.13) = 5.5; P < .01] (Figures 8 and 9).

Bottom Line: The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried.The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions.These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

View Article: PubMed Central - PubMed

Affiliation: Evaluation Laboratory of Psychobioactive and Toxicology, Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. edvaldo.ra@gmail.com

ABSTRACT
The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

Show MeSH
Related in: MedlinePlus