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Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and alpha-tocopherol presents in the extract of leaves of Cissus sicyoides L. (Vitaceae).

de Almeida ER, Rafael KR, Couto GB, Ishigami AB - J. Biomed. Biotechnol. (2009)

Bottom Line: The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried.The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions.These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

View Article: PubMed Central - PubMed

Affiliation: Evaluation Laboratory of Psychobioactive and Toxicology, Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. edvaldo.ra@gmail.com

ABSTRACT
The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

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Effect of extracts (EHDg andEADg) in Marble-burying test. The extracts were evaluated in relation toDiazepam. All data cited are the mean ±S.D. The data were evaluated by aone-way variance analysis (ANOVA) with Duncan's post hoc test. The data fromthis figure show that the effect of fear produced by glass beads was significant comparedwith the control and the diazepam *[F(1.14) = 5.8; P < .01], and 								**[F (1.12)= 5.7; P < .05]. 10 animals were used in each group.
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fig6: Effect of extracts (EHDg andEADg) in Marble-burying test. The extracts were evaluated in relation toDiazepam. All data cited are the mean ±S.D. The data were evaluated by aone-way variance analysis (ANOVA) with Duncan's post hoc test. The data fromthis figure show that the effect of fear produced by glass beads was significant comparedwith the control and the diazepam *[F(1.14) = 5.8; P < .01], and **[F (1.12)= 5.7; P < .05]. 10 animals were used in each group.

Mentions: To examine this premise,we studied the effect of the representative of CS on burying behavior. Asexpected, control exhibited significant decrease in the marble buryingbehavior. However, CS prompted an increase in marble burying (300, 600, and100 mg. kg1, IP. These data were evaluated using the analysis ofvariance one way (ANOVA) followed by a post hoc Duncan's tests. *[F (1.14)= 5.8; P < .01], and **[F (1.12) = 5.7; P < .05] (Figure 6).


Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and alpha-tocopherol presents in the extract of leaves of Cissus sicyoides L. (Vitaceae).

de Almeida ER, Rafael KR, Couto GB, Ishigami AB - J. Biomed. Biotechnol. (2009)

Effect of extracts (EHDg andEADg) in Marble-burying test. The extracts were evaluated in relation toDiazepam. All data cited are the mean ±S.D. The data were evaluated by aone-way variance analysis (ANOVA) with Duncan's post hoc test. The data fromthis figure show that the effect of fear produced by glass beads was significant comparedwith the control and the diazepam *[F(1.14) = 5.8; P < .01], and 								**[F (1.12)= 5.7; P < .05]. 10 animals were used in each group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2655362&req=5

fig6: Effect of extracts (EHDg andEADg) in Marble-burying test. The extracts were evaluated in relation toDiazepam. All data cited are the mean ±S.D. The data were evaluated by aone-way variance analysis (ANOVA) with Duncan's post hoc test. The data fromthis figure show that the effect of fear produced by glass beads was significant comparedwith the control and the diazepam *[F(1.14) = 5.8; P < .01], and **[F (1.12)= 5.7; P < .05]. 10 animals were used in each group.
Mentions: To examine this premise,we studied the effect of the representative of CS on burying behavior. Asexpected, control exhibited significant decrease in the marble buryingbehavior. However, CS prompted an increase in marble burying (300, 600, and100 mg. kg1, IP. These data were evaluated using the analysis ofvariance one way (ANOVA) followed by a post hoc Duncan's tests. *[F (1.14)= 5.8; P < .01], and **[F (1.12) = 5.7; P < .05] (Figure 6).

Bottom Line: The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried.The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions.These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

View Article: PubMed Central - PubMed

Affiliation: Evaluation Laboratory of Psychobioactive and Toxicology, Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. edvaldo.ra@gmail.com

ABSTRACT
The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.

Show MeSH
Related in: MedlinePlus