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Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean.

Grann VR, Ziv E, Joseph CK, Neugut AI, Wei Y, Jacobson JS, Horwitz MS, Bowman N, Beckmann K, Hershman DL - Br. J. Haematol. (2008)

Bottom Line: A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count.In a linear regression model that included percentage African ancestry, national origin, cytokines, socio-economic factors and the ELA2 rs57834246 SNP, only the DARC rs2814778 genotype and C-reactive protein were associated with ANC (P < 0.0001).A better understanding of these associations may help to improve cancer outcomes among individuals of African ancestry.

View Article: PubMed Central - PubMed

Affiliation: Departments of Medicine, Epidemiology, and Health Policy, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. vrg2@columbia.edu

ABSTRACT
Neutropenia associated with race/ethnicity has essentially been unexplained and, although thought to be benign, may affect therapy for cancer or other illnesses. A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count. We therefore analysed the association of the rs2814778 CC, TC and TT genotypes with absolute neutrophil count (ANC) among asymptomatic women from the Caribbean, Europe and the United States. Among 261 study participants, 33/47 women from Barbados/Trinidad-Tobago, 34/49 from Haiti, 26/37 from Jamaica, and 29/38 US-born black women, but only 4/50 from the Dominican Republic and 0/40 US- or European-born whites (P = 0.0001) had the CC genotype. In a linear regression model that included percentage African ancestry, national origin, cytokines, socio-economic factors and the ELA2 rs57834246 SNP, only the DARC rs2814778 genotype and C-reactive protein were associated with ANC (P < 0.0001). Women with the CC genotype had lower ANC than other women. Further research is needed on the associations of rs2814778 genotype with neutropenia and treatment delay in the setting of cancer. A better understanding of these associations may help to improve cancer outcomes among individuals of African ancestry.

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Related in: MedlinePlus

Median ANC counts (x109/l) by DARC rs2814778 genotype and ethnic group. The height of each bar represents the median ANC count for women with that genotype in that ethnic group. Above each bar are the percentage distributions of the genotypes in each ethnic group. Bar_Tri_T, Barbados/Trinidad-Tobago; Afi-Amer, African-American.
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fig01: Median ANC counts (x109/l) by DARC rs2814778 genotype and ethnic group. The height of each bar represents the median ANC count for women with that genotype in that ethnic group. Above each bar are the percentage distributions of the genotypes in each ethnic group. Bar_Tri_T, Barbados/Trinidad-Tobago; Afi-Amer, African-American.

Mentions: The median ANC for women with the CC genotype varied little by ethnic group (P = 0·91). However, the medians for women with the TC and TT genotypes ranged from 3544 (Caucasian) to 5963 (African American) and from 3444 (Caucasian) to 5304 (Barbadian/Trinidad-Tobago) respectively (Fig 1). Because of small sample sizes, these differences were not statistically significant (P = 0·08 for both TC and TT).


Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean.

Grann VR, Ziv E, Joseph CK, Neugut AI, Wei Y, Jacobson JS, Horwitz MS, Bowman N, Beckmann K, Hershman DL - Br. J. Haematol. (2008)

Median ANC counts (x109/l) by DARC rs2814778 genotype and ethnic group. The height of each bar represents the median ANC count for women with that genotype in that ethnic group. Above each bar are the percentage distributions of the genotypes in each ethnic group. Bar_Tri_T, Barbados/Trinidad-Tobago; Afi-Amer, African-American.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2655355&req=5

fig01: Median ANC counts (x109/l) by DARC rs2814778 genotype and ethnic group. The height of each bar represents the median ANC count for women with that genotype in that ethnic group. Above each bar are the percentage distributions of the genotypes in each ethnic group. Bar_Tri_T, Barbados/Trinidad-Tobago; Afi-Amer, African-American.
Mentions: The median ANC for women with the CC genotype varied little by ethnic group (P = 0·91). However, the medians for women with the TC and TT genotypes ranged from 3544 (Caucasian) to 5963 (African American) and from 3444 (Caucasian) to 5304 (Barbadian/Trinidad-Tobago) respectively (Fig 1). Because of small sample sizes, these differences were not statistically significant (P = 0·08 for both TC and TT).

Bottom Line: A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count.In a linear regression model that included percentage African ancestry, national origin, cytokines, socio-economic factors and the ELA2 rs57834246 SNP, only the DARC rs2814778 genotype and C-reactive protein were associated with ANC (P < 0.0001).A better understanding of these associations may help to improve cancer outcomes among individuals of African ancestry.

View Article: PubMed Central - PubMed

Affiliation: Departments of Medicine, Epidemiology, and Health Policy, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. vrg2@columbia.edu

ABSTRACT
Neutropenia associated with race/ethnicity has essentially been unexplained and, although thought to be benign, may affect therapy for cancer or other illnesses. A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count. We therefore analysed the association of the rs2814778 CC, TC and TT genotypes with absolute neutrophil count (ANC) among asymptomatic women from the Caribbean, Europe and the United States. Among 261 study participants, 33/47 women from Barbados/Trinidad-Tobago, 34/49 from Haiti, 26/37 from Jamaica, and 29/38 US-born black women, but only 4/50 from the Dominican Republic and 0/40 US- or European-born whites (P = 0.0001) had the CC genotype. In a linear regression model that included percentage African ancestry, national origin, cytokines, socio-economic factors and the ELA2 rs57834246 SNP, only the DARC rs2814778 genotype and C-reactive protein were associated with ANC (P < 0.0001). Women with the CC genotype had lower ANC than other women. Further research is needed on the associations of rs2814778 genotype with neutropenia and treatment delay in the setting of cancer. A better understanding of these associations may help to improve cancer outcomes among individuals of African ancestry.

Show MeSH
Related in: MedlinePlus