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Efficacy of Amitraz plus Metaflumizone for the treatment of canine demodicosis associated with Malassezia pachydermatis.

Tarallo VD, Lia RP, Sasanelli M, Cafarchia C, Otranto D - Parasit Vectors (2009)

Bottom Line: The dog was treated with cephalexin and topically with metaflumizone plus amitraz spot on formulation at two weeks intervals until two consecutive skin scrapings resulted negative for mites.The number of adult mites statistically decreased at follow-up with a reduction of approximately 42 and 94% at +14 and +28 days post treatment (p.t.) respectively.The dog was negative for both bacteria and M. pachydermatis at 14 days p.t., coinciding with improved general clinical conditions, recovering skin lesions and no further signs of pruritus.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Veterinary Public Health and Animal Sciences Faculty of Veterinary Medicine, University of Bari, 70010, Valenzano, Bari, Italy. d.otranto@veterinaria.uniba.it.

ABSTRACT
This case reports the efficacy of metaflumizone plus amitraz spot-on formulation (ProMeris Duo(R); Fort Dodge) against generalized demodectic mange. A two year-old male dog presented at clinical examination with poor general condition, diffused alopecia, crusted lesions, pruritus, skin scales and pustules. Demodex mites, Malassezia pachydermatis yeasts and bacteria were diagnosed. The dog was treated with cephalexin and topically with metaflumizone plus amitraz spot on formulation at two weeks intervals until two consecutive skin scrapings resulted negative for mites. The number of adult mites statistically decreased at follow-up with a reduction of approximately 42 and 94% at +14 and +28 days post treatment (p.t.) respectively. Nymphs and larvae could not be detected from +28 day p.t. while eggs were no longer present +42 day p.t. The dog was negative for both bacteria and M. pachydermatis at 14 days p.t., coinciding with improved general clinical conditions, recovering skin lesions and no further signs of pruritus. These results show that metaflumizone plus amitraz associated with the antibiotic therapy is highly effective for treating generalized demodectic mange and could also be effective toward controlling M. pachydermatis opportunistic infections.

No MeSH data available.


Related in: MedlinePlus

Patient at day +42, +56, +70 and +84 post treatment.
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Figure 2: Patient at day +42, +56, +70 and +84 post treatment.

Mentions: The results of parasitological examination from each skin site at each observation time are reported in Additional file 1. At day 0 each sample was positive for different stages of Demodex canis (Additional file 1) with the highest parasitic load recorded on the thorax and thighs. The number of adult mites statistically decreased at follow-up with a reduction of approximately 42 and 94% at +14 and +28 days p.t. respectively. Nymphs and larvae could no longer be detected from day +28 p.t., while eggs were no longer observed from day +42 p.t. At the same time, general condition improved and skin lesions resolved, and clinical signs of pruritus disappeared at +14 day p.t. (Figure 1). Lesions due to scratching rapidly resolved over the whole body surface, as well as around the eyes, resulting in hair growth and resolution of alopecic areas. At +70 day p.t. the animal presented in good general condition, including a weight gain of +7 kilos (Figure 2). No adverse reactions to treatment were recorded at any of the follow-ups.


Efficacy of Amitraz plus Metaflumizone for the treatment of canine demodicosis associated with Malassezia pachydermatis.

Tarallo VD, Lia RP, Sasanelli M, Cafarchia C, Otranto D - Parasit Vectors (2009)

Patient at day +42, +56, +70 and +84 post treatment.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2654875&req=5

Figure 2: Patient at day +42, +56, +70 and +84 post treatment.
Mentions: The results of parasitological examination from each skin site at each observation time are reported in Additional file 1. At day 0 each sample was positive for different stages of Demodex canis (Additional file 1) with the highest parasitic load recorded on the thorax and thighs. The number of adult mites statistically decreased at follow-up with a reduction of approximately 42 and 94% at +14 and +28 days p.t. respectively. Nymphs and larvae could no longer be detected from day +28 p.t., while eggs were no longer observed from day +42 p.t. At the same time, general condition improved and skin lesions resolved, and clinical signs of pruritus disappeared at +14 day p.t. (Figure 1). Lesions due to scratching rapidly resolved over the whole body surface, as well as around the eyes, resulting in hair growth and resolution of alopecic areas. At +70 day p.t. the animal presented in good general condition, including a weight gain of +7 kilos (Figure 2). No adverse reactions to treatment were recorded at any of the follow-ups.

Bottom Line: The dog was treated with cephalexin and topically with metaflumizone plus amitraz spot on formulation at two weeks intervals until two consecutive skin scrapings resulted negative for mites.The number of adult mites statistically decreased at follow-up with a reduction of approximately 42 and 94% at +14 and +28 days post treatment (p.t.) respectively.The dog was negative for both bacteria and M. pachydermatis at 14 days p.t., coinciding with improved general clinical conditions, recovering skin lesions and no further signs of pruritus.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Veterinary Public Health and Animal Sciences Faculty of Veterinary Medicine, University of Bari, 70010, Valenzano, Bari, Italy. d.otranto@veterinaria.uniba.it.

ABSTRACT
This case reports the efficacy of metaflumizone plus amitraz spot-on formulation (ProMeris Duo(R); Fort Dodge) against generalized demodectic mange. A two year-old male dog presented at clinical examination with poor general condition, diffused alopecia, crusted lesions, pruritus, skin scales and pustules. Demodex mites, Malassezia pachydermatis yeasts and bacteria were diagnosed. The dog was treated with cephalexin and topically with metaflumizone plus amitraz spot on formulation at two weeks intervals until two consecutive skin scrapings resulted negative for mites. The number of adult mites statistically decreased at follow-up with a reduction of approximately 42 and 94% at +14 and +28 days post treatment (p.t.) respectively. Nymphs and larvae could not be detected from +28 day p.t. while eggs were no longer present +42 day p.t. The dog was negative for both bacteria and M. pachydermatis at 14 days p.t., coinciding with improved general clinical conditions, recovering skin lesions and no further signs of pruritus. These results show that metaflumizone plus amitraz associated with the antibiotic therapy is highly effective for treating generalized demodectic mange and could also be effective toward controlling M. pachydermatis opportunistic infections.

No MeSH data available.


Related in: MedlinePlus