Limits...
Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort.

Byberg L, Melhus H, Gedeborg R, Sundström J, Ahlbom A, Zethelius B, Berglund LG, Wolk A, Michaëlsson K - BMJ (2009)

Bottom Line: The relative rate reduction attributable to high physical activity was 32% for low and 22% for medium physical activity.After 10 years of follow-up their increased physical activity was associated with reduced mortality to the level of men with unchanged high physical activity (1.10, 0.87 to 1.38).Increased physical activity in middle age is eventually followed by a reduction in mortality to the same level as seen among men with constantly high physical activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE-75185 Uppsala, Sweden. liisa.byberg@surgsci.uu.se

ABSTRACT

Objective: To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation.

Design: Population based cohort study with follow-up over 35 years.

Setting: Municipality of Uppsala, Sweden.

Participants: 2205 men aged 50 in 1970-3 who were re-examined at ages 60, 70, 77, and 82 years.

Main outcome measure: Total (all cause) mortality.

Results: The absolute mortality rate was 27.1, 23.6, and 18.4 per 1000 person years in the groups with low, medium, and high physical activity, respectively. The relative rate reduction attributable to high physical activity was 32% for low and 22% for medium physical activity. Men who increased their physical activity level between the ages of 50 and 60 continued to have a higher mortality rate during the first five years of follow-up (adjusted hazard ratio 2.64, 95% confidence interval 1.32 to 5.27, compared with unchanged high physical activity). After 10 years of follow-up their increased physical activity was associated with reduced mortality to the level of men with unchanged high physical activity (1.10, 0.87 to 1.38). The reduction in mortality associated with increased physical activity (0.51, 0.26 to 0.97, compared with unchanged low physical activity) was similar to that associated with smoking cessation (0.64, 0.53 to 0.78, compared with continued smoking).

Conclusions: Increased physical activity in middle age is eventually followed by a reduction in mortality to the same level as seen among men with constantly high physical activity. This reduction is comparable with that associated with smoking cessation.

Show MeSH
Fig 1 Cohort study base and numbers included in present study. Deaths presented as cumulative mortality from start of survey 1. Numbers not available represent those who were not living in the Uppsala region at time of invitation. They did not contribute information on physical activity at that survey but they could return at later survey if they had moved back to Uppsala. Numbers included represent those who were included in analysis. All men were traced in population register for mortality data, including those “not available”
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2654773&req=5

fig1: Fig 1 Cohort study base and numbers included in present study. Deaths presented as cumulative mortality from start of survey 1. Numbers not available represent those who were not living in the Uppsala region at time of invitation. They did not contribute information on physical activity at that survey but they could return at later survey if they had moved back to Uppsala. Numbers included represent those who were included in analysis. All men were traced in population register for mortality data, including those “not available”

Mentions: The present investigation used data from the population based Uppsala longitudinal study of adult men (ULSAM, www.pubcare.uu.se/ULSAM). Figure 1 shows the study population . In 1970 all 2841 men born in 1920-4 and living in the municipality of Uppsala, Sweden, were invited to attend a health survey (survey 1).16 Of those invited, 2322 men (82%) aged 49-51 participated. Participants in survey 1 were invited for reinvestigations at ages 60, 70, and 77 (surveys 2-4). Participants in surveys 3 and 4 were invited for reinvestigation at age 82 (survey 5).


Total mortality after changes in leisure time physical activity in 50 year old men: 35 year follow-up of population based cohort.

Byberg L, Melhus H, Gedeborg R, Sundström J, Ahlbom A, Zethelius B, Berglund LG, Wolk A, Michaëlsson K - BMJ (2009)

Fig 1 Cohort study base and numbers included in present study. Deaths presented as cumulative mortality from start of survey 1. Numbers not available represent those who were not living in the Uppsala region at time of invitation. They did not contribute information on physical activity at that survey but they could return at later survey if they had moved back to Uppsala. Numbers included represent those who were included in analysis. All men were traced in population register for mortality data, including those “not available”
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2654773&req=5

fig1: Fig 1 Cohort study base and numbers included in present study. Deaths presented as cumulative mortality from start of survey 1. Numbers not available represent those who were not living in the Uppsala region at time of invitation. They did not contribute information on physical activity at that survey but they could return at later survey if they had moved back to Uppsala. Numbers included represent those who were included in analysis. All men were traced in population register for mortality data, including those “not available”
Mentions: The present investigation used data from the population based Uppsala longitudinal study of adult men (ULSAM, www.pubcare.uu.se/ULSAM). Figure 1 shows the study population . In 1970 all 2841 men born in 1920-4 and living in the municipality of Uppsala, Sweden, were invited to attend a health survey (survey 1).16 Of those invited, 2322 men (82%) aged 49-51 participated. Participants in survey 1 were invited for reinvestigations at ages 60, 70, and 77 (surveys 2-4). Participants in surveys 3 and 4 were invited for reinvestigation at age 82 (survey 5).

Bottom Line: The relative rate reduction attributable to high physical activity was 32% for low and 22% for medium physical activity.After 10 years of follow-up their increased physical activity was associated with reduced mortality to the level of men with unchanged high physical activity (1.10, 0.87 to 1.38).Increased physical activity in middle age is eventually followed by a reduction in mortality to the same level as seen among men with constantly high physical activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Sciences, Section of Orthopaedics, and Uppsala Clinical Research Centre, Uppsala University, SE-75185 Uppsala, Sweden. liisa.byberg@surgsci.uu.se

ABSTRACT

Objective: To examine how change in level of physical activity after middle age influences mortality and to compare it with the effect of smoking cessation.

Design: Population based cohort study with follow-up over 35 years.

Setting: Municipality of Uppsala, Sweden.

Participants: 2205 men aged 50 in 1970-3 who were re-examined at ages 60, 70, 77, and 82 years.

Main outcome measure: Total (all cause) mortality.

Results: The absolute mortality rate was 27.1, 23.6, and 18.4 per 1000 person years in the groups with low, medium, and high physical activity, respectively. The relative rate reduction attributable to high physical activity was 32% for low and 22% for medium physical activity. Men who increased their physical activity level between the ages of 50 and 60 continued to have a higher mortality rate during the first five years of follow-up (adjusted hazard ratio 2.64, 95% confidence interval 1.32 to 5.27, compared with unchanged high physical activity). After 10 years of follow-up their increased physical activity was associated with reduced mortality to the level of men with unchanged high physical activity (1.10, 0.87 to 1.38). The reduction in mortality associated with increased physical activity (0.51, 0.26 to 0.97, compared with unchanged low physical activity) was similar to that associated with smoking cessation (0.64, 0.53 to 0.78, compared with continued smoking).

Conclusions: Increased physical activity in middle age is eventually followed by a reduction in mortality to the same level as seen among men with constantly high physical activity. This reduction is comparable with that associated with smoking cessation.

Show MeSH