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Oxidative stress biomarkers and lifestyles in Japanese healthy people.

Sakano N, Wang DH, Takahashi N, Wang B, Sauriasari R, Kanbara S, Sato Y, Takigawa T, Takaki J, Ogino K - J Clin Biochem Nutr (2009)

Bottom Line: On the other hand, mean urinary 8-OHdG showed differences only by age group.The present study shows that urinary 8-isoprostane is associated with lipid peroxidation related-lifestyles such as smoking, and urinary 8-OHdG is associated with arteriosclerosis related-factors such as Hs-CRP.Our findings suggest that 8-isoprostane and 8-OHdG appear to be prospective biomarkers for early prediction of lifestyle related-disease risk at the population level.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

ABSTRACT
The urinary concentrations of 8-isoprostane and 8-hydroxy-2'-deoxyguanosine (8-OHdG), which are biomarkers of oxidative stress, were measured in 677 Japanese people without any diseases, and their correlations with lifestyle facotrs, lifestyle-related blood biochemical parameters, and dietary intake of antioxidative vitamins were investigated. The mean urinary concentration of 8-isoprostane and 8-OHdG was 0.58 ng/mg creatinine and 8.43 ng/mg creatinine, respectively. Mean urinary 8-isoprostane was significantly different in terms of age, gender, smoking and alcohol consumption but not different in terms of body mass index (BMI) and exercise. By multiple regression analysis, urinary 8-isoprostane was significantly influenced by smoking and age. On the other hand, mean urinary 8-OHdG showed differences only by age group. Multiple regression analysis revealed that urinary 8-OHdG was significantly influenced by age, smoking, body weight, levels of high-sensitivity C-reactive protein (Hs-CRP) and low density lipoprotein-cholesterol in females, although it was significantly influenced by body weight in males. The present study shows that urinary 8-isoprostane is associated with lipid peroxidation related-lifestyles such as smoking, and urinary 8-OHdG is associated with arteriosclerosis related-factors such as Hs-CRP. Our findings suggest that 8-isoprostane and 8-OHdG appear to be prospective biomarkers for early prediction of lifestyle related-disease risk at the population level.

No MeSH data available.


Related in: MedlinePlus

Pearson’s correlation between urinary 8-isoprostane and 8-OHdG in Japanese healthy people. No significant correlations were found in both males (r = −0.099, p = 0.090, n = 293), and females (r = −0.036, p = 0.485, n = 384).
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Figure 1: Pearson’s correlation between urinary 8-isoprostane and 8-OHdG in Japanese healthy people. No significant correlations were found in both males (r = −0.099, p = 0.090, n = 293), and females (r = −0.036, p = 0.485, n = 384).

Mentions: As shown in Fig. 1 and Table 5-1, we did not find any significant association between urinary 8-isoprostane and 8-OHdG (r = −0.066, p = 0.086).


Oxidative stress biomarkers and lifestyles in Japanese healthy people.

Sakano N, Wang DH, Takahashi N, Wang B, Sauriasari R, Kanbara S, Sato Y, Takigawa T, Takaki J, Ogino K - J Clin Biochem Nutr (2009)

Pearson’s correlation between urinary 8-isoprostane and 8-OHdG in Japanese healthy people. No significant correlations were found in both males (r = −0.099, p = 0.090, n = 293), and females (r = −0.036, p = 0.485, n = 384).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2654475&req=5

Figure 1: Pearson’s correlation between urinary 8-isoprostane and 8-OHdG in Japanese healthy people. No significant correlations were found in both males (r = −0.099, p = 0.090, n = 293), and females (r = −0.036, p = 0.485, n = 384).
Mentions: As shown in Fig. 1 and Table 5-1, we did not find any significant association between urinary 8-isoprostane and 8-OHdG (r = −0.066, p = 0.086).

Bottom Line: On the other hand, mean urinary 8-OHdG showed differences only by age group.The present study shows that urinary 8-isoprostane is associated with lipid peroxidation related-lifestyles such as smoking, and urinary 8-OHdG is associated with arteriosclerosis related-factors such as Hs-CRP.Our findings suggest that 8-isoprostane and 8-OHdG appear to be prospective biomarkers for early prediction of lifestyle related-disease risk at the population level.

View Article: PubMed Central - PubMed

Affiliation: Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

ABSTRACT
The urinary concentrations of 8-isoprostane and 8-hydroxy-2'-deoxyguanosine (8-OHdG), which are biomarkers of oxidative stress, were measured in 677 Japanese people without any diseases, and their correlations with lifestyle facotrs, lifestyle-related blood biochemical parameters, and dietary intake of antioxidative vitamins were investigated. The mean urinary concentration of 8-isoprostane and 8-OHdG was 0.58 ng/mg creatinine and 8.43 ng/mg creatinine, respectively. Mean urinary 8-isoprostane was significantly different in terms of age, gender, smoking and alcohol consumption but not different in terms of body mass index (BMI) and exercise. By multiple regression analysis, urinary 8-isoprostane was significantly influenced by smoking and age. On the other hand, mean urinary 8-OHdG showed differences only by age group. Multiple regression analysis revealed that urinary 8-OHdG was significantly influenced by age, smoking, body weight, levels of high-sensitivity C-reactive protein (Hs-CRP) and low density lipoprotein-cholesterol in females, although it was significantly influenced by body weight in males. The present study shows that urinary 8-isoprostane is associated with lipid peroxidation related-lifestyles such as smoking, and urinary 8-OHdG is associated with arteriosclerosis related-factors such as Hs-CRP. Our findings suggest that 8-isoprostane and 8-OHdG appear to be prospective biomarkers for early prediction of lifestyle related-disease risk at the population level.

No MeSH data available.


Related in: MedlinePlus