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Beneficial Effects of Cocoa in Perivascular Mato Cells of Cerebral Arterioles in SHR-SP (Izm) Rats.

Mato T, Kamei M, Ito R, Sawano M, Inokuchi K, Nakata K, Yamaguchi A, Kouki T, Mitsuhashi U, Mato M - J Clin Biochem Nutr (2009)

Bottom Line: Vascular cells exhibited some signs of pathology.Signs of pathology in vascular cells were also decreased.Superoxides may impair Mato cells and vascular cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency and Critical Care Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe-shi, Saitama 350-8550, Japan.

ABSTRACT
As previously reported, the cerebral arterioles are surrounded by unique perivascular Mato cells. They contain many inclusion bodies rich in hydrolytic enzymes, and have strong uptake capacity. They are thus considered scavenger cells of vascular and neural tissues in steady-state. In this study, employing hypertensive SHR-SP (Izm) rats, the viability of Mato cells was investigated. In hypertensive rats, the capacity for uptake of horse radish peroxidase (HRP) and the activity of acid phosphatase (ACPase) of Mato cells were markedly reduced, and on electron-microscopic examination Mato cells were found to include heterogeneous contents and appeared electron-dense and degenerated. Vascular cells exhibited some signs of pathology. However, in hypertensive rats fed chow containing 0.25% cocoa, the uptake capacity and ACPase activity of Mato cells for HRP were enhanced, and on electron-microscopic examination Mato cells appeared healthy, with mitochondria with nearly normal profiles. Signs of pathology in vascular cells were also decreased. Superoxides may impair Mato cells and vascular cells.

No MeSH data available.


Related in: MedlinePlus

(1) Schematic presentation of Mato cells (type I to type III) in NF rats and in CF rats. (2) Circular graph shows percentage of Mato cells in each type of NF rats.
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Figure 6: (1) Schematic presentation of Mato cells (type I to type III) in NF rats and in CF rats. (2) Circular graph shows percentage of Mato cells in each type of NF rats.

Mentions: A schematic presentation of Mato cells and percentages of Mato cells of each type are shown in Fig. 6.


Beneficial Effects of Cocoa in Perivascular Mato Cells of Cerebral Arterioles in SHR-SP (Izm) Rats.

Mato T, Kamei M, Ito R, Sawano M, Inokuchi K, Nakata K, Yamaguchi A, Kouki T, Mitsuhashi U, Mato M - J Clin Biochem Nutr (2009)

(1) Schematic presentation of Mato cells (type I to type III) in NF rats and in CF rats. (2) Circular graph shows percentage of Mato cells in each type of NF rats.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2654470&req=5

Figure 6: (1) Schematic presentation of Mato cells (type I to type III) in NF rats and in CF rats. (2) Circular graph shows percentage of Mato cells in each type of NF rats.
Mentions: A schematic presentation of Mato cells and percentages of Mato cells of each type are shown in Fig. 6.

Bottom Line: Vascular cells exhibited some signs of pathology.Signs of pathology in vascular cells were also decreased.Superoxides may impair Mato cells and vascular cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency and Critical Care Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe-shi, Saitama 350-8550, Japan.

ABSTRACT
As previously reported, the cerebral arterioles are surrounded by unique perivascular Mato cells. They contain many inclusion bodies rich in hydrolytic enzymes, and have strong uptake capacity. They are thus considered scavenger cells of vascular and neural tissues in steady-state. In this study, employing hypertensive SHR-SP (Izm) rats, the viability of Mato cells was investigated. In hypertensive rats, the capacity for uptake of horse radish peroxidase (HRP) and the activity of acid phosphatase (ACPase) of Mato cells were markedly reduced, and on electron-microscopic examination Mato cells were found to include heterogeneous contents and appeared electron-dense and degenerated. Vascular cells exhibited some signs of pathology. However, in hypertensive rats fed chow containing 0.25% cocoa, the uptake capacity and ACPase activity of Mato cells for HRP were enhanced, and on electron-microscopic examination Mato cells appeared healthy, with mitochondria with nearly normal profiles. Signs of pathology in vascular cells were also decreased. Superoxides may impair Mato cells and vascular cells.

No MeSH data available.


Related in: MedlinePlus