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Abnormal growth factor/cytokine network in gastric cancer.

Tahara E - Cancer Microenviron (2008)

Bottom Line: Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis.Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer.Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Hiroshima University, Hiroshima Cancer Seminar Foundation, Naka-ku, Hiroshima, Japan. etahara@h-gan.com

ABSTRACT
Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis. However, these abnormal growth factor/cytokine networks differ in the two histological types of gastric cancer. Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer. Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.

No MeSH data available.


Related in: MedlinePlus

Tumor microenvironment of gastric cancer is composed of interaction between cancer cells and stromal cells via growth factor/cytokine network
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Fig1: Tumor microenvironment of gastric cancer is composed of interaction between cancer cells and stromal cells via growth factor/cytokine network

Mentions: Gastric cancer cells express a wide array of growth factors and cytokines that act via autocrine, paracrine and juxtacrine mechanisms in the tumor microenvironment [2, 3]. These complex interactions between tumor cells and stromal cells confer morphogenesis, angiogenesis, invasion and metastasis [Fig. 1]. Again the expression of these mediators varies depending on the histological subtype.Fig. 1


Abnormal growth factor/cytokine network in gastric cancer.

Tahara E - Cancer Microenviron (2008)

Tumor microenvironment of gastric cancer is composed of interaction between cancer cells and stromal cells via growth factor/cytokine network
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2654359&req=5

Fig1: Tumor microenvironment of gastric cancer is composed of interaction between cancer cells and stromal cells via growth factor/cytokine network
Mentions: Gastric cancer cells express a wide array of growth factors and cytokines that act via autocrine, paracrine and juxtacrine mechanisms in the tumor microenvironment [2, 3]. These complex interactions between tumor cells and stromal cells confer morphogenesis, angiogenesis, invasion and metastasis [Fig. 1]. Again the expression of these mediators varies depending on the histological subtype.Fig. 1

Bottom Line: Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis.Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer.Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.

View Article: PubMed Central - PubMed

Affiliation: Hiroshima University, Hiroshima Cancer Seminar Foundation, Naka-ku, Hiroshima, Japan. etahara@h-gan.com

ABSTRACT
Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis. However, these abnormal growth factor/cytokine networks differ in the two histological types of gastric cancer. Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer. Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.

No MeSH data available.


Related in: MedlinePlus