Limits...
Birth control for centrioles

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Like DNA, centrioles need to duplicate only once per cell cycle... Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication... To determine whether a similar mechanism keeps centrioles in check, Rogers et al. blocked Drosophila cells' production of different proteins that combine to form a ubiquitin-adding complex... Loss of one of these proteins, Slimb, allowed cells to fashion extra centrioles, the researchers found... However, a mutant form of Plk4 that Slimb couldn't latch onto clung to the centrioles throughout the cell cycle and caused their over-duplication... Plk4 serves as a licensing factor for centriole copying, Rogers et al. suggest... During mitosis, it sets the stage for the next cell division by phosphorylating an unidentified protein (or proteins) that will later instigate centriole duplication... Slimb and its protein partners then ubiquitinate Plk4, so that no enzyme remains on the centrioles by the time they are ready for copying... Thus, the organelles are duplicated once only.

No MeSH data available.


Related in: MedlinePlus

Cells unable to break down Plk4 manufacture extra centrioles (arrows).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2654291&req=5

fig1: Cells unable to break down Plk4 manufacture extra centrioles (arrows).


Birth control for centrioles
Cells unable to break down Plk4 manufacture extra centrioles (arrows).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2654291&req=5

fig1: Cells unable to break down Plk4 manufacture extra centrioles (arrows).

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Like DNA, centrioles need to duplicate only once per cell cycle... Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication... To determine whether a similar mechanism keeps centrioles in check, Rogers et al. blocked Drosophila cells' production of different proteins that combine to form a ubiquitin-adding complex... Loss of one of these proteins, Slimb, allowed cells to fashion extra centrioles, the researchers found... However, a mutant form of Plk4 that Slimb couldn't latch onto clung to the centrioles throughout the cell cycle and caused their over-duplication... Plk4 serves as a licensing factor for centriole copying, Rogers et al. suggest... During mitosis, it sets the stage for the next cell division by phosphorylating an unidentified protein (or proteins) that will later instigate centriole duplication... Slimb and its protein partners then ubiquitinate Plk4, so that no enzyme remains on the centrioles by the time they are ready for copying... Thus, the organelles are duplicated once only.

No MeSH data available.


Related in: MedlinePlus