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Characterization of arterial wave reflection in healthy bonnet macaques: feasibility of applanation tonometry.

Lazar J, Qureshi G, Kamran H, Rosenblum LA, Kral JG, Salciccioli L - J. Biomed. Biotechnol. (2009)

Bottom Line: On multivariate analysis, HR (P < .001) and CRL (P = .005) were independent predictors of AI (R2 = 0.46, P < .001).Body Mass Index (BMI) and AI were independent predictors of higher LV mass on multivariate analysis (P < .001 and P = .03).Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. jason.lazar@downstate.edu

ABSTRACT
Nonhuman primates are commonly used in cardiovascular research. Increased arterial stiffness is a marker of subclinical atherosclerosis and higher CV risk. We determined the augmentation index (AI) using applanation tonometry in 61 healthy monkeys (59% female, age 1-25 years). Technically adequate studies were obtained in all subjects and required 1.5 +/- 1.3 minutes. The brachial artery provided the highest yield (95%). AI was correlated with heart rate (HR) (r = -0.65, P < .001), crown rump length (CRL) (r = 0.42, P = .001), and left ventricular (LV) mass determined using echocardiography (r = 0.52, P < .001). On multivariate analysis, HR (P < .001) and CRL (P = .005) were independent predictors of AI (R2 = 0.46, P < .001). Body Mass Index (BMI) and AI were independent predictors of higher LV mass on multivariate analysis (P < .001 and P = .03). In conclusion, applanation tonometry is feasible for determining AI. Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass.

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Related in: MedlinePlus

Relation between AI and LV mass.
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fig2: Relation between AI and LV mass.

Mentions: AI was also correlated with thefollowing echocardiographic indices: LVEDD (r = 0.56, P < .001), PWT(r = 0.35, P = .02), LVESD (r = 0.60, P < .001), LV mass (r = 0.52, P < .001)(Figure 2), and LVMI (CRL) (r = 0.41, P = .007). LV mass was significantly correlated with age(r = 0.44, P < .001). Upon partialcorrelation adjusting for age, AI remained significantly correlated with LVmass (r = 0.45, P = .003) (Figure 2) and with LVMI (CRL) (r = 0.36, P = .01). On multivariate analysis, using age, HR, systolic BP, gender and CRL, andweight as independent variables, HR (P < .001) and CRL (P = .005)were independent predictors of AI with a trend toward age (P = .10)(R2 = 0.46, P < .001). On multiple linear regression using age, gender,BMI, systolic BP, and AI as independent variables, BMI (P < .001) andAI (P = .03) were independent predictors of LV mass (R2 = 0.46, P < .001).


Characterization of arterial wave reflection in healthy bonnet macaques: feasibility of applanation tonometry.

Lazar J, Qureshi G, Kamran H, Rosenblum LA, Kral JG, Salciccioli L - J. Biomed. Biotechnol. (2009)

Relation between AI and LV mass.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2654075&req=5

fig2: Relation between AI and LV mass.
Mentions: AI was also correlated with thefollowing echocardiographic indices: LVEDD (r = 0.56, P < .001), PWT(r = 0.35, P = .02), LVESD (r = 0.60, P < .001), LV mass (r = 0.52, P < .001)(Figure 2), and LVMI (CRL) (r = 0.41, P = .007). LV mass was significantly correlated with age(r = 0.44, P < .001). Upon partialcorrelation adjusting for age, AI remained significantly correlated with LVmass (r = 0.45, P = .003) (Figure 2) and with LVMI (CRL) (r = 0.36, P = .01). On multivariate analysis, using age, HR, systolic BP, gender and CRL, andweight as independent variables, HR (P < .001) and CRL (P = .005)were independent predictors of AI with a trend toward age (P = .10)(R2 = 0.46, P < .001). On multiple linear regression using age, gender,BMI, systolic BP, and AI as independent variables, BMI (P < .001) andAI (P = .03) were independent predictors of LV mass (R2 = 0.46, P < .001).

Bottom Line: On multivariate analysis, HR (P < .001) and CRL (P = .005) were independent predictors of AI (R2 = 0.46, P < .001).Body Mass Index (BMI) and AI were independent predictors of higher LV mass on multivariate analysis (P < .001 and P = .03).Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. jason.lazar@downstate.edu

ABSTRACT
Nonhuman primates are commonly used in cardiovascular research. Increased arterial stiffness is a marker of subclinical atherosclerosis and higher CV risk. We determined the augmentation index (AI) using applanation tonometry in 61 healthy monkeys (59% female, age 1-25 years). Technically adequate studies were obtained in all subjects and required 1.5 +/- 1.3 minutes. The brachial artery provided the highest yield (95%). AI was correlated with heart rate (HR) (r = -0.65, P < .001), crown rump length (CRL) (r = 0.42, P = .001), and left ventricular (LV) mass determined using echocardiography (r = 0.52, P < .001). On multivariate analysis, HR (P < .001) and CRL (P = .005) were independent predictors of AI (R2 = 0.46, P < .001). Body Mass Index (BMI) and AI were independent predictors of higher LV mass on multivariate analysis (P < .001 and P = .03). In conclusion, applanation tonometry is feasible for determining AI. Reference values are provided for AI in bonnet macaques, in whom higher AI is related to HR and CRL, and in turn contributes to higher LV mass.

Show MeSH
Related in: MedlinePlus