Limits...
Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy.

Dickler A, Ivanov O, Francescatti D - World J Surg Oncol (2009)

Bottom Line: In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored.APBI allows the radiation treatment to be accomplished in one week or less.XB is a form of balloon-based APBI that uses an electronic source generated by a mobile controller unit.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiation Oncology, Little Company of Mary Hospital, Evergreen Park, IL 60805, USA. atd22_99@yahoo.com

ABSTRACT

Background: In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored. APBI allows the radiation treatment to be accomplished in one week or less. XB is a form of balloon-based APBI that uses an electronic source generated by a mobile controller unit. Investigators have also explored IORT treatment that delivers a single fraction of radiation in the operating suite at the time of surgery.

Methods: We report on the first patient treated with XB to deliver IORT.

Results: IORT treatment utilizing XB is feasible and can be accomplished with a total procedure time of approximately 2 hours.

Conclusion: Further research on XB and other methods of IORT is needed to establish clinical efficacy and safety for patients with early-stage breast cancer.

Show MeSH

Related in: MedlinePlus

Retention sutures are placed to potentially increase the balloon-to-skin distance and to more closely approximate the balloon to the surrounding breast tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2651878&req=5

Figure 2: Retention sutures are placed to potentially increase the balloon-to-skin distance and to more closely approximate the balloon to the surrounding breast tissue.

Mentions: During machine calibration, retention sutures were placed in the breast tissue superficial to the inflated balloon (Figure 2). The retention sutures serve to build-up the subcutaneous tissue to potentially increase the balloon-to-skin distance and to more closely approximate the balloon to the surrounding breast tissue. An intraoperative ultrasound was then performed to evaluate the balloon-to-skin distance and the degree of air and/or fluid in the breast tissue surrounding the balloon. For the purposes of this protocol, a minimum of 1-cm balloon to skin distance is required. If the patients are found to have ≥ 0.7-cm and < 1.0-cm of balloon-skin-distance they are offered outpatient balloon-based ABPI. If patients have a balloon-skin-distance of < 0.7-cm, balloon-based brachytherapy is aborted. If patients are found to have large air pockets surrounding the balloon on ultrasound, the balloon is inflated by 10 cc to the next largest size and re-evaluated via ultrasound.


Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy.

Dickler A, Ivanov O, Francescatti D - World J Surg Oncol (2009)

Retention sutures are placed to potentially increase the balloon-to-skin distance and to more closely approximate the balloon to the surrounding breast tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2651878&req=5

Figure 2: Retention sutures are placed to potentially increase the balloon-to-skin distance and to more closely approximate the balloon to the surrounding breast tissue.
Mentions: During machine calibration, retention sutures were placed in the breast tissue superficial to the inflated balloon (Figure 2). The retention sutures serve to build-up the subcutaneous tissue to potentially increase the balloon-to-skin distance and to more closely approximate the balloon to the surrounding breast tissue. An intraoperative ultrasound was then performed to evaluate the balloon-to-skin distance and the degree of air and/or fluid in the breast tissue surrounding the balloon. For the purposes of this protocol, a minimum of 1-cm balloon to skin distance is required. If the patients are found to have ≥ 0.7-cm and < 1.0-cm of balloon-skin-distance they are offered outpatient balloon-based ABPI. If patients have a balloon-skin-distance of < 0.7-cm, balloon-based brachytherapy is aborted. If patients are found to have large air pockets surrounding the balloon on ultrasound, the balloon is inflated by 10 cc to the next largest size and re-evaluated via ultrasound.

Bottom Line: In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored.APBI allows the radiation treatment to be accomplished in one week or less.XB is a form of balloon-based APBI that uses an electronic source generated by a mobile controller unit.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiation Oncology, Little Company of Mary Hospital, Evergreen Park, IL 60805, USA. atd22_99@yahoo.com

ABSTRACT

Background: In an effort to overcome the barriers to BCT, alternative methods of delivering radiation therapy have been explored. APBI allows the radiation treatment to be accomplished in one week or less. XB is a form of balloon-based APBI that uses an electronic source generated by a mobile controller unit. Investigators have also explored IORT treatment that delivers a single fraction of radiation in the operating suite at the time of surgery.

Methods: We report on the first patient treated with XB to deliver IORT.

Results: IORT treatment utilizing XB is feasible and can be accomplished with a total procedure time of approximately 2 hours.

Conclusion: Further research on XB and other methods of IORT is needed to establish clinical efficacy and safety for patients with early-stage breast cancer.

Show MeSH
Related in: MedlinePlus