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SPIO-enhanced MRI findings of well-differentiated hepatocellular carcinomas: correlation with MDCT findings.

Kim SH, Lee WJ, Lim HK, Park CK - Korean J Radiol (2009)

Bottom Line: Based on the use of multivariate analysis, the CT attenuation pattern was the only factor that affected the proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2(*)-weighted images (p < 0.001).Most well-differentiated HCCs show hyperintensity on SPIO-enhanced MRI, although the lesions show various CT attenuation patterns.The CT attenuation pattern is the main factor that affects the proportion of hyperintense well-differentiated HCCs as depicted on SPIO-enhanced MRI.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea. kshyun@skku.edu

ABSTRACT

Objective: This study was designed to assess superparamagnetic iron oxide (SPIO)-enhanced MRI findings of well-differentiated hepatocellular carcinomas (HCCs) correlated with their multidetector-row CT (MDCT) findings.

Materials and methods: Seventy-two patients with 84 pathologically proven well-differentiated HCCs underwent triple-phase MDCT and SPIO-enhanced MRI at a magnetic field strength of 1.5 Tesla (n = 49) and 3.0 Tesla (n = 23). Two radiologists in consensus retrospectively reviewed the CT and MR images for attenuation value and the signal intensity of each tumor. The proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2(*)-weighted images were compared in terms of tumor size (< 1 cm and > 1 cm), five CT attenuation patterns based on arterial and equilibrium phases and magnetic field strength, by the use of univariate and multivariate analyses.

Results: Seventy-eight (93%) and 71 (85%) HCCs were identified by CT and on SPIO-enhanced T2- and T2(*)-weighted images, respectively. For the CT attenuation pattern, one (14%) of seven isodense-isodense, four (67%) of six hypodense-hypodense, four (80%) of five isodense-hypodense, 14 (88%) of 16 hyperdense-isodense and 48 (96%) of 50 hyperdense-hypodense HCCs were hyperintense (Cochran-Armitage test for trend, p < 0.001). Based on the use of multivariate analysis, the CT attenuation pattern was the only factor that affected the proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2(*)-weighted images (p < 0.001). Tumor size or magnetic field strength was not a factor that affected the proportion of hyperintense HCCs based on the use of univariate and multivariate analysis (p > 0.05).

Conclusion: Most well-differentiated HCCs show hyperintensity on SPIO-enhanced MRI, although the lesions show various CT attenuation patterns. The CT attenuation pattern is the main factor that affects the proportion of hyperintense well-differentiated HCCs as depicted on SPIO-enhanced MRI.

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57-year-old man with 1.9-cm well-differentiated hepatocellular carcinoma in segment V.A, B. Contrast-enhanced CT scans obtained at arterial (A) and equilibrium (B) phases show small nodule with isodense-hypodense pattern (arrows).C. Ferucarbotran-enhanced T2*-weighted fast field-echo (TR/TE, 129/9.2 msec; flip angle, 20°) axial image obtained at 3.0 T shows discrete hyperintense nodule (arrow).
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Figure 2: 57-year-old man with 1.9-cm well-differentiated hepatocellular carcinoma in segment V.A, B. Contrast-enhanced CT scans obtained at arterial (A) and equilibrium (B) phases show small nodule with isodense-hypodense pattern (arrows).C. Ferucarbotran-enhanced T2*-weighted fast field-echo (TR/TE, 129/9.2 msec; flip angle, 20°) axial image obtained at 3.0 T shows discrete hyperintense nodule (arrow).

Mentions: Among 84 well-differentiated HCCs, 78 (93%) (Figs. 1-4) were identified by CT and 71 (85%) were identified as hyperintense as seen on SPIO-enhanced T2- and/or T2*-weighted MR images (Figs. 1, 2).


SPIO-enhanced MRI findings of well-differentiated hepatocellular carcinomas: correlation with MDCT findings.

Kim SH, Lee WJ, Lim HK, Park CK - Korean J Radiol (2009)

57-year-old man with 1.9-cm well-differentiated hepatocellular carcinoma in segment V.A, B. Contrast-enhanced CT scans obtained at arterial (A) and equilibrium (B) phases show small nodule with isodense-hypodense pattern (arrows).C. Ferucarbotran-enhanced T2*-weighted fast field-echo (TR/TE, 129/9.2 msec; flip angle, 20°) axial image obtained at 3.0 T shows discrete hyperintense nodule (arrow).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2651447&req=5

Figure 2: 57-year-old man with 1.9-cm well-differentiated hepatocellular carcinoma in segment V.A, B. Contrast-enhanced CT scans obtained at arterial (A) and equilibrium (B) phases show small nodule with isodense-hypodense pattern (arrows).C. Ferucarbotran-enhanced T2*-weighted fast field-echo (TR/TE, 129/9.2 msec; flip angle, 20°) axial image obtained at 3.0 T shows discrete hyperintense nodule (arrow).
Mentions: Among 84 well-differentiated HCCs, 78 (93%) (Figs. 1-4) were identified by CT and 71 (85%) were identified as hyperintense as seen on SPIO-enhanced T2- and/or T2*-weighted MR images (Figs. 1, 2).

Bottom Line: Based on the use of multivariate analysis, the CT attenuation pattern was the only factor that affected the proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2(*)-weighted images (p < 0.001).Most well-differentiated HCCs show hyperintensity on SPIO-enhanced MRI, although the lesions show various CT attenuation patterns.The CT attenuation pattern is the main factor that affects the proportion of hyperintense well-differentiated HCCs as depicted on SPIO-enhanced MRI.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea. kshyun@skku.edu

ABSTRACT

Objective: This study was designed to assess superparamagnetic iron oxide (SPIO)-enhanced MRI findings of well-differentiated hepatocellular carcinomas (HCCs) correlated with their multidetector-row CT (MDCT) findings.

Materials and methods: Seventy-two patients with 84 pathologically proven well-differentiated HCCs underwent triple-phase MDCT and SPIO-enhanced MRI at a magnetic field strength of 1.5 Tesla (n = 49) and 3.0 Tesla (n = 23). Two radiologists in consensus retrospectively reviewed the CT and MR images for attenuation value and the signal intensity of each tumor. The proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2(*)-weighted images were compared in terms of tumor size (< 1 cm and > 1 cm), five CT attenuation patterns based on arterial and equilibrium phases and magnetic field strength, by the use of univariate and multivariate analyses.

Results: Seventy-eight (93%) and 71 (85%) HCCs were identified by CT and on SPIO-enhanced T2- and T2(*)-weighted images, respectively. For the CT attenuation pattern, one (14%) of seven isodense-isodense, four (67%) of six hypodense-hypodense, four (80%) of five isodense-hypodense, 14 (88%) of 16 hyperdense-isodense and 48 (96%) of 50 hyperdense-hypodense HCCs were hyperintense (Cochran-Armitage test for trend, p < 0.001). Based on the use of multivariate analysis, the CT attenuation pattern was the only factor that affected the proportion of hyperintense HCCs as depicted on SPIO-enhanced T2- or T2(*)-weighted images (p < 0.001). Tumor size or magnetic field strength was not a factor that affected the proportion of hyperintense HCCs based on the use of univariate and multivariate analysis (p > 0.05).

Conclusion: Most well-differentiated HCCs show hyperintensity on SPIO-enhanced MRI, although the lesions show various CT attenuation patterns. The CT attenuation pattern is the main factor that affects the proportion of hyperintense well-differentiated HCCs as depicted on SPIO-enhanced MRI.

Show MeSH
Related in: MedlinePlus