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Ultrasonographic findings of medullary thyroid carcinoma: a comparison with papillary thyroid carcinoma.

Kim SH, Kim BS, Jung SL, Lee JW, Yang PS, Kang BJ, Lim HW, Kim JY, Whang IY, Kwon HS, Jung CK - Korean J Radiol (2009)

Bottom Line: The mean size (longest diameter) of MTC nodules was 19 +/- 13.9 mm and the mean size (longest diameter) of PTC nodules was 11 +/- 7.4 mm; this difference was statistically significant (p < 0.05).An ovoid to round shape was more prevalent for MTC lesions than for PTC lesions (p < 0.05).The US findings for MTC are not greatly different from PTC except for the prevalence of an ovoid to round shape.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Objective: This study was designed to evaluate the ultrasonographic (US) findings of medullary thyroid carcinoma (MTC) as compared to findings for papillary thyroid carcinoma (PTC).

Materials and methods: The study included 21 cases of MTC that were surgically diagnosed between 2002 and 2007 and 114 cases of PTC that were diagnosed in 2007. Two radiologists reached a consensus in the evaluation of the US findings. The US findings were classified as recommended by the Thyroid Study Group of the Korean Society of Neuroradiology and Head and Neck Radiology (KSNHNR) and each nodule was identified as suspicious malignant, indeterminate or probably benign. The findings of medullary and papillary carcinomas were compared with use of the chi-squared test.

Results: The common US findings for MTCs were solid internal content (91%), an ovoid to round shape (57%), marked hypoechogenicity (52%) and calcifications (52%). Among the 21 cases of MTC nodules, 17 (81%) were classified as suspicious malignant nodules. The mean size (longest diameter) of MTC nodules was 19 +/- 13.9 mm and the mean size (longest diameter) of PTC nodules was 11 +/- 7.4 mm; this difference was statistically significant (p < 0.05). An ovoid to round shape was more prevalent for MTC lesions than for PTC lesions (p < 0.05).

Conclusion: The US criteria for suspicious malignant nodules as recommended by the Thyroid Study Group of the KSNHNR correspond to most MTC cases. The US findings for MTC are not greatly different from PTC except for the prevalence of an ovoid to round shape.

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Related in: MedlinePlus

Ultrasonography performed on 61-year-old female with medullary thyroid carcinoma.Transverse scan shows 18 mm, solid, ovoid to round, hypoechoic nodule with smooth border. This nodule was classified as indeterminate.
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Figure 2: Ultrasonography performed on 61-year-old female with medullary thyroid carcinoma.Transverse scan shows 18 mm, solid, ovoid to round, hypoechoic nodule with smooth border. This nodule was classified as indeterminate.

Mentions: The US findings of the MTCs and PTCs are summarized in the Table 1. For the MTCs, a solid internal content (19 of 21, 90.5%), ovoid to round shape (12 of 21, 57.1%), marked hypoechogenicity (11 of 21, 52.4%), microcalcifications or macrocalcifications (11 of 21, 52.4%) and a spiculated or ill-defined margin (17 of 21, 80.9%) were the prevailing findings seen on US. For 21 MTCs, 17 (81%) were categorized as suspicious malignant nodules, and four (19%) were categorized as indeterminate nodules (Figs. 1, 2). None of the lesions were categorized as probably benign nodules. For the PTCs, the prevailing findings as seen on US were a solid internal content (110 of 114, 96.5%), taller than wide shape (48 of 114, 48%), irregular border (48 of 114, 42.1%), marked hypoechogenicity (65 of 114, 57.0%) and microcalcifications or macrocalcifications (74 of 114, 64.9%). For 114 PTCs, 107 (94%) were categorized as suspicious malignant nodules and seven (6%) were categorized as indeterminate nodules (Fig. 3). The mean size (19 ± 13.9 mm vs. 11 ± 7.5 mm) and ovoid to round shape (57.1% vs. 25.4%) were statistically different between the MTCs and PTCs. However, the internal content, margin, echogenicity and calcifications were not statistically significantly different between the two types of nodules. Most of the MTC and PTC nodules were classified as suspicious malignant; however, the frequency of an indeterminate nodule was higher for the MTCs than for the PTCs.


Ultrasonographic findings of medullary thyroid carcinoma: a comparison with papillary thyroid carcinoma.

Kim SH, Kim BS, Jung SL, Lee JW, Yang PS, Kang BJ, Lim HW, Kim JY, Whang IY, Kwon HS, Jung CK - Korean J Radiol (2009)

Ultrasonography performed on 61-year-old female with medullary thyroid carcinoma.Transverse scan shows 18 mm, solid, ovoid to round, hypoechoic nodule with smooth border. This nodule was classified as indeterminate.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2651443&req=5

Figure 2: Ultrasonography performed on 61-year-old female with medullary thyroid carcinoma.Transverse scan shows 18 mm, solid, ovoid to round, hypoechoic nodule with smooth border. This nodule was classified as indeterminate.
Mentions: The US findings of the MTCs and PTCs are summarized in the Table 1. For the MTCs, a solid internal content (19 of 21, 90.5%), ovoid to round shape (12 of 21, 57.1%), marked hypoechogenicity (11 of 21, 52.4%), microcalcifications or macrocalcifications (11 of 21, 52.4%) and a spiculated or ill-defined margin (17 of 21, 80.9%) were the prevailing findings seen on US. For 21 MTCs, 17 (81%) were categorized as suspicious malignant nodules, and four (19%) were categorized as indeterminate nodules (Figs. 1, 2). None of the lesions were categorized as probably benign nodules. For the PTCs, the prevailing findings as seen on US were a solid internal content (110 of 114, 96.5%), taller than wide shape (48 of 114, 48%), irregular border (48 of 114, 42.1%), marked hypoechogenicity (65 of 114, 57.0%) and microcalcifications or macrocalcifications (74 of 114, 64.9%). For 114 PTCs, 107 (94%) were categorized as suspicious malignant nodules and seven (6%) were categorized as indeterminate nodules (Fig. 3). The mean size (19 ± 13.9 mm vs. 11 ± 7.5 mm) and ovoid to round shape (57.1% vs. 25.4%) were statistically different between the MTCs and PTCs. However, the internal content, margin, echogenicity and calcifications were not statistically significantly different between the two types of nodules. Most of the MTC and PTC nodules were classified as suspicious malignant; however, the frequency of an indeterminate nodule was higher for the MTCs than for the PTCs.

Bottom Line: The mean size (longest diameter) of MTC nodules was 19 +/- 13.9 mm and the mean size (longest diameter) of PTC nodules was 11 +/- 7.4 mm; this difference was statistically significant (p < 0.05).An ovoid to round shape was more prevalent for MTC lesions than for PTC lesions (p < 0.05).The US findings for MTC are not greatly different from PTC except for the prevalence of an ovoid to round shape.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Objective: This study was designed to evaluate the ultrasonographic (US) findings of medullary thyroid carcinoma (MTC) as compared to findings for papillary thyroid carcinoma (PTC).

Materials and methods: The study included 21 cases of MTC that were surgically diagnosed between 2002 and 2007 and 114 cases of PTC that were diagnosed in 2007. Two radiologists reached a consensus in the evaluation of the US findings. The US findings were classified as recommended by the Thyroid Study Group of the Korean Society of Neuroradiology and Head and Neck Radiology (KSNHNR) and each nodule was identified as suspicious malignant, indeterminate or probably benign. The findings of medullary and papillary carcinomas were compared with use of the chi-squared test.

Results: The common US findings for MTCs were solid internal content (91%), an ovoid to round shape (57%), marked hypoechogenicity (52%) and calcifications (52%). Among the 21 cases of MTC nodules, 17 (81%) were classified as suspicious malignant nodules. The mean size (longest diameter) of MTC nodules was 19 +/- 13.9 mm and the mean size (longest diameter) of PTC nodules was 11 +/- 7.4 mm; this difference was statistically significant (p < 0.05). An ovoid to round shape was more prevalent for MTC lesions than for PTC lesions (p < 0.05).

Conclusion: The US criteria for suspicious malignant nodules as recommended by the Thyroid Study Group of the KSNHNR correspond to most MTC cases. The US findings for MTC are not greatly different from PTC except for the prevalence of an ovoid to round shape.

Show MeSH
Related in: MedlinePlus